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  • 1
    Electronic Resource
    Electronic Resource
    Effets des anxiolytiques sur la prise de boisson en situation nouvelle et familière (1976)
    Springer
    Psychopharmacology 50 (1976), S. 41-45 
    Details
    ISSN: 1432-2072
    Keywords: Water intake ; Benzodiazepines ; Phenobarbital ; Meprobamate ; Mecloqualone ; Rats and mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In water-deprived rats and mice, animals trained to the test situation spent more time in drinking than naive animals (first exposure to the test situation). The time spent in drinking, either during 5 min or during 10 min was recorded. As compared to controls, benzodiazepines, phenobarbital, meprobamate, and mecloqualone increased drinking time whether the experiments were run on naive or on experienced animals [5 or 10 (in mice) and 9 (in rats) exposures in the test situation]. All drugs were injected i.p. 30 min before testing. This release of the drinking behavior was more pronounced during the last 5 min than during the first 5 min of the 10 min test session. These results suggest that: 1. The inhibition of water intake of naive animals as compared to trained rats and mice, could be related to some emotional factors elicited by the first exposure to an unknown situation. 2. The increase in drinking time induced by the antianxiety drugs in a novel and in a familiar situation seems difficult to correlate only with the antianxiety action of these compounds. 3. Antianxiety drugs could interfere with the regulatory mechanism of thirst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634152
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  • 2
    Electronic Resource
    Electronic Resource
    Pro-opiomelanocortin gene is expressed in post-implantation mouse embryos and enhances growth potential of myogenic cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 198 (1993), S. 265-272 
    Details
    ISSN: 1058-8388
    Keywords: POMC ; Muscle Development ; Growth factors ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: We previously showed that the adrenocorticotropin hormone (ACTH) is a mitogen for myoblasts and is present in post-implantation mammalian embryos (Cossu et al. [1989] Dev. Biol. 131:331-336; De Angelis et al. [1992] Dev. Biol. 151:446-458). In this paper, we investigated the expression of the corresponding gene, pro-opiomelanocortin (POMC), by in situ hybridization and polymerase chain reaction. In situ analysis revealed low level expression in the basal layer of 10.5 d.p.c. neural tube and in several discrete areas around the dorsal aorta. By more sensitive Reverse-transcription polymerase chain reaction (RT-PCR) analysis, expression was detected also in developing limb buds and in cultured myogenic cells, but not in fibroblasts.To investigate the possible role of POMC gene expression in myogenesis, we induced its over-expression in proliferating myoblasts. Upon sub-optimal growth conditions, over-expressing cells were found to give rise to clones larger than control cells. The differentiation potential of POMC over-expressing myogenic cells was unchanged. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001980404
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    Paper (German National Licenses)
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