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The activities of brain dopamine-β-hydroxylase and catechol-O-methyl transferase in schizophrenics and controls (1978)

Cross, A. J. ; Crow, T. J. ; Killpack, W. S. ; [et al.]

Springer

Psychopharmacology 59 (1978), S. 117-121

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ISSN: 1432-2072

Keywords: Dopamine-β-hydroxylase ; Catechol-O-methyltransferase ; Schizophrenia ; Postmortem brains

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract It has been suggested that deterioration of central noradrenergic pathways may be responsible for the production of certain schizophrenic symptoms, and that such a degeneration might be reflected in lowered dopamine-β-hydroxylase (DBH) activity in the brains of schizophrenics. The present study revealed that in rats lowered DBH activity was a sensitive index of noradrenergic degeneration. In the postmortem brains of 12 controls and 12 schizophrenics, however, no significant difference in DBH activity between controls and schizophrenics was found. DBH activity was relatively unstable postmortem and adversely affected by neuroleptic drugs, and these factors may have contributed to the previous finding of lowered DBH activity in the brains of schizophrenics. The activity of catechol-O-methyl transferase, which has also been previously reported as low in the brains of schizophrenics, was found to be no different in the controls of the present study.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00427744

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Characterisation of stroma-dependent blast colony-forming cells in human marrow (1987)

Gordon, M. Y. ; Dowding, C. R. ; Riley, G. P. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 130 (1987), S. 150-156

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ISSN: 0021-9541

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Human bone marrow contains a population of haemopoietic progenitor cells that can be distinguished by their ability to adhere to preformed stromal layers cultured in the presence of methylprednisolon [MP+] and form blast cell colonies. The stromal layers function in the colony assay after they have been heavily irradiated but not after they have been passaged. The binding of the progenitor cells to the stromal cells is complete after 2 hours of coincubation, and stromal layers of 9.6 cm2 can provide adhesion sites for at least 2,000 blast colony-forming cells. The blast colony-forming cells were shown by micromanipulation to self-renew as well as to give rise to multipotential and lineage-committed colony-forming progenitor cells.

Additional Material: 4 Ill.