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  • 1
    Electronic Resource
    Electronic Resource
    Phase II study of iproplatin (CHIP) in patients with cisplatin-refractory germ cell tumors; the need for alternative strategies in the investigation of new agents in GCT (1992)
    Springer
    Investigational new drugs 10 (1992), S. 327-330 
    Details
    ISSN: 1573-0646
    Keywords: germ cell tumor ; iproplatin ; CHIP ; cisplatin-refractory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifteen patients with advanced, cisplatin-refractory germ cell tumors (GCT) were treated with iproplatin (CHIP). No objective responses were noted in any of the patients treated. By restricting the entry criteria to heavily pre-treated patients, the identification of new active agents in phase II trials may be hindered. Alternative strategies for the investigation of new agents in patients with GCT should be considered, particularly when studying the efficacy and relative toxicity of platinum analogues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00944190
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  • 2
    Electronic Resource
    Electronic Resource
    (Na++K+)-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice (1987)
    Springer
    Neurochemical research 12 (1987), S. 1081-1086 
    Details
    ISSN: 1573-6903
    Keywords: Shiverer ; myelin ; (Na++K+)-ATPase ; brain ; antibody ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The myelin-deficient Shiverer (Shi/Shi) mutant mouse may be a useful model in assessing the dependence of brain (Na++K+)-ATPase concentration and composition on myelin membrane formation. Brain microsomal membranes from age-matched control (+/+) and Shiverer (Shi/Shi) mice were fractionated by differential centrifugation and sucrose gradient sedimentation. No reduction in (Na++K+)-ATPase specific activity was measured in whole homogenates, high-and low-speed fractions or gradient fractions from brains of Shi/Shi mice as compared to those of +/+ mice. In addition, sodium dodecylsulfatepolyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting with antisera specific for mouse brain (Na++K+)-ATPase revealed no significant difference in catalytic subunit composition between fractions of +/+ and Shi/Shi brains. The similar results obtained for both +/+ and myelin-deficient Shi/Shi mice suggest that myelin contributes little to total brain (Na++K+)-ATPase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00971708
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  • 3
    Electronic Resource
    Electronic Resource
    Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain (1989)
    Springer
    Neurochemical research 14 (1989), S. 667-675 
    Details
    ISSN: 1573-6903
    Keywords: Glucose ; 3-hydroxybutyrate ; lactate ; brain ; development ; ketones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The dependence of cerebral energy metabolism upon glucose, 3-hydroxybutyrate, and lactate as fuel sources during the postnatal period was investigated. The brain of 6 day old suckling pups used very little glucose, but by the 15th postnatal day glucose was the major catabolite. Hydroxybutyrate was not a major brain fuel at either 6 or 15 days of age. Its utilization accounted for only 19% of the brain's total energy needs at 15 days of age, even though blood ketone concentrations are near maximal at this time. Seventy percent of the cerebral metabolic requirements were met by lactate in animals aged 6 days. The major role played by lactate as a substrate for brain metabolism in young pups was not a result of abnormally elevated blood lactate concentrations. The slow catabolism of glucose in young brain can not be explained by low rates of influx or inadequate enzymatic capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964877
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  • 4
    Electronic Resource
    Electronic Resource
    Hexose diphosphates and phosphofructokinase in rat brain during development (1994)
    Springer
    Neurochemical research 19 (1994), S. 1301-1310 
    Details
    ISSN: 1573-6903
    Keywords: Fructose 2,6-diphosphate ; glucose 1,6-diphosphate ; development ; brain ; 6-phosphofructo-1-kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fructose 2,6-diphosphate and glucose 1,6-diphosphate concentrations were determined during late gestation and over the course of suckling in rat brain cortex and cerebellum. Cortex fructose 2,6-diphosphate concentration was greatest in neonatal animals and gradually declined thereafter by 25% to reach the adult level at 15 days of age. In contrast, the glucose 1,6-diphosphate concentration increased 4-fold over the same period to reach its highest level by postnatal day 15. Neither cerebellar fructose 2,6-diphosphate nor glucose 1,6-diphosphate concentrations varied significantly. Six day cortex 6-phosphofructo-1-kinase was less sensitive to inhibition by citrate than the enzyme obtained from 15 day pups, and fructose 2,6-diphosphate was better than glucose 1,6-diphosphate at relieving the inhibition imposed by citrate at either age. It is suggested that the rise in cerebral glucose use which occurs during suckling cannot be attributed to either changes in the concentrations of fructose 2,6-diphosphate or glucose 1,6-diphosphate, or the age-related differential sensitivity of 6-phosphofructo-1-kinase toward these effectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006822
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  • 5
    Electronic Resource
    Electronic Resource
    Phase II trial of topotecan in patients with cisplatin-refractory germ cell tumors (1995)
    Springer
    Investigational new drugs 13 (1995), S. 163-165 
    Details
    ISSN: 1573-0646
    Keywords: topotecan ; germ cell tumor ; cisplatin-refractory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifteen patients with advanced, cisplatin-refractory germ cell tumors (GCT) were treated on a phase II trial with topotecan. None of the 14 evaluable patients achieved a complete or partial response. Myelosuppression was the major toxicity. The median nadir leukocyte count was 1.75 cells/mm3, neutrophil count was 1.55 cells/mm3, hemoglobin was 8.75 gm/dl, and platelet count was 20,500 cells/mm3. Topotecan is not efficacious in the treatment of cisplatin-refractory GCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00872866
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  • 6
    Electronic Resource
    Electronic Resource
    Phase II Trial of Pyrazoloacridine in Patients with Cisplatin-Refractory Germ Cell Tumors (2000)
    Springer
    Investigational new drugs 18 (2000), S. 265-267 
    Details
    ISSN: 1573-0646
    Keywords: pyrazoloacridine ; germ cell tumor ; cisplatin-refractory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Thirteen patients with cisplatin-refractory germ cell tumors weretreated on a Phase II trial with pyrazoloacridine.Pyrazoloacridine was given intravenously at 600 mg/m3 everythree weeks. The median nadir leucocyte count was 2.5cells/mm3, hemoglobin was 10.8 g/dl, and platelet count was126,000 cells/m3. None of the thirteen evaluable patientsachieved a major response. Pyrazoloacridine is not efficaciousin the treatment of cisplatin-refractory germ cell tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006434008357
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  • 7
    Electronic Resource
    Electronic Resource
    Immunological comparison of desmosomal components from several bovine tissues (1984)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 26 (1984), S. 35-45 
    Details
    ISSN: 0730-2312
    Keywords: desmosome ; immunological analysis ; immunoblotting ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: A panel of monoclonal antibodies and conventional antisera directed against desmosomal proteins from bovine muzzle epidermis was used Io identify immunologically related proteins from two other bovine stratified squamous epithelia, cornea and esophagus. Desmosome-enriched tissue fractions were prepared from epidermis, cornea, and esophagus. These tissue extracts were electrophoresed on sodium dodecyl sulfate (SDS)-polyacrylamide gels, blotted onto nitrocellulose paper, and labeled using an indirect immunoperoxidase technique. Labeling with the conventional antisera demonstrates that each of the previously characterized epidermal desmosomal proteins or protein families has an immunologically cross-reacting counterpart in cornea and esophagus. However, chemical differences between homologous desmosomal proteins in these three tissues have also been detected. The corresponding proteins in the different tissues have similar but not always identical apparent molecular weights. Moreover, tissue-restricted antigenic determinants were detected in two of the desmosomal protein families using four monoclonal antibodies, each of which recognizes a distinct antigenic determinant.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240260104
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  • 8
    Electronic Resource
    Electronic Resource
    Biological effects of roentgen rays. The determination of critical periods in mammalian development with x-rays (1935)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 56 (1935), S. 97-117 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1000560106
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Tracheobronchial epithelium in the adult rhesus monkey: A quantitative histochemical and ultrastructural study (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 184 (1989), S. 31-40 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Previous studies of the intrapulmo-nary conducting airways of sheep and rabbit have demonstrated marked diversity in the epithelial populations lining them. Because studies of trachea and centriaci-nar regions of macaque monkeys suggested that primates may be even more diverse, the present study was designed to characterize the epithelial population throughout the airway tree of one primate species, the rhesus monkey. Trachea and intrapulmonary airways of the right cranial and middle lobes of glutaraldehyde/ paraformaldehyde-infused lungs of five adult rhesus monkeys were microdissected following the axial pathway. Each branch was assigned a binary number indicating its specific location within the tree. The trachea and six generations of intrapulmonary airway from the right cranial lobe were evaluated for ultrastructure and quantitative histology as were those of the right middle lobe for quantitative carbohydrate histochemistry. Four cell types were identified throughout the tree: ciliated, mucous goblet, small mucous granule, and basal. The tallest epithelium lined the trachea; the shortest, the respiratory bronchiole. The most cells per unit length of basement membrane were in proximal intrapulmonary bronchi; the least, in the respiratory bronchiole. The nonciliated bronchiolar epithelial or Clara cell was restricted to respiratory bronchioles. Sulfomucins were present in the vast majority of surface goblet cells in the trachea and proximal bronchi. In proximal bronchi, neutral glycoconjugates predominated in glands and acidic glycoconjugates in surface epithelium. In terminal and respiratory bronchioles the ratio of acidic gly-coconjugate to neutral glycoconjugate equaled that in proximal bronchi, although glands were not present. Sulfomucins were minimal in terminal airways. We conclude that the characteristics of the epithelial lining of the mammalian tracheobronchial airway tree are very species-specific. The lining of the rhesus monkey does not have the diversity in cell types in different airway generations observed in sheep and rabbit. Also, the populations lining these airways in the rhesus are very different from either the sheep or rabbit in number, proportions of different cell types, glycoconjugate content, and distribution of specific cell types.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001840104
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  • 10
    Electronic Resource
    Electronic Resource
    Symposium on the development and structure of the lymphatic system. V. The development of the lymphatics in the small intestine of the pig (1908)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 2 (1908), S. 57-58 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1090020106
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    Paper (German National Licenses)
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