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A robust logistic discrimination model (1997)

COX, TREVOR F. ; PEARCE, KIM F.

Springer

Statistics and computing 7 (1997), S. 155-161

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ISSN: 1573-1375

Keywords: Logistic discrimination ; model diagnostics ; outliers ; residuals

Source: Springer Online Journal Archives 1860-2000

Topics: Computer Science , Mathematics

Notes: Abstract Logistic discrimination is a well documented method for classifying observations to two or more groups. However, estimation of the discriminant rule can be seriously affected by outliers. To overcome this, Cox and Ferry produced a robust logistic discrimination technique. Although their method worked in practice, parameter estimation was sometimes prone to convergence problems. This paper proposes a simplified robust logistic model which does not have any such problems and which takes a generalized linear model form. Misclassification rates calculated in a simulation exercise are used to compare the new method with ordinary logistic discrimination. Model diagnostics are also presented. The newly proposed model is then used on data collected from pregnant women at two district general hospitals. A robust logistic discriminant is calculated which can be used to predict accurately which method of feeding a woman will eventually use: breast feeding or bottle feeding.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1018530001135

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Freeze-fracture of lipids and model membrane systems (1989)

Hope, Michael J. ; Wong, Kim F. ; Cullis, Pieter R.

New York, NY : Wiley-Blackwell

Journal of Electron Microscopy Technique 13 (1989), S. 277-287

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ISSN: 0741-0581

Keywords: Liposome ; Unilamellar vesicle ; Hexagonal HII phase ; Lipidic particle ; Filipin ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Natural Sciences in General

Notes: Model membrane systems are used extensively in all aspects of membrane research, and freeze-fracture is the preeminent procedure for directly visualizing local structure in these lipid dispersions. Here we describe in detail the formation of liposomes and how freeze-fracture is routinely employed as a complementary technique to biophysical and biochemical procedures in the characterization of multilamellar vesicles (most commonly known as liposomes) and unilamellar vesicles. Many preparative procedures exist for the formation of multi- and unilamellar vesicles. Examples of each system are given and their properties as well as freeze-fracture morphology are discussed. The detection of lipid-phase transitions is considered, in particular, with emphasis on the application of freeze-fracture to the study of lipid polymorphism. We briefly discuss the fracturing of apolar lipids which do not adopt bilayer structures but which can be stabilized into microemulsions by a phospholipid monolayer. Finally, a critical assessment is made of filipin as a morphological marker for cholesterol domains in the plane of the bilayer.

Additional Material: 11 Ill.