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  • 1
    Electronic Resource
    Electronic Resource
    Electron microscopic observations on eosinophil leukocyte granules in dog blood (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 174 (1972), S. 165-173 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The eosinophil granules of the dog have a dense matrix with or without a light peripheral rim. Lamellated crystalloids are demonstrated in their dense matrix. The lamellation consists of alternating dark and light bands resembling crystalloids of other species. The center to center distance between the consecutive dark bands measures approximately 107 Å. The crystalloids appear to take rather variable forms ranging from large, triangular to small, elongated or irregular shape.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091740203
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  • 2
    Electronic Resource
    Electronic Resource
    Fine structure of tracheo-bronchial epithelial nerves of the cat (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 185 (1976), S. 85-91 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The nerves in and immediately under the epithelial layer of the trachea and primary bronchi of the cat are studied with the electron microscope. The axons are unmyelinated and contain microtubules and mitochondria. Epithelial axons are observed throughout the entire epithelial layer, but, are usually concentrated in the basal area immediately above the basal lamina. Most axons are near the basal cells; others are in the vicinity of granulated cells or occur in the intercellular spaces between other columnar cells. A few of the epithelial axons are large and crowded with axoplasmic mitochondria. The possibility that some epithelial axons may have sensory functions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091850108
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  • 3
    Electronic Resource
    Electronic Resource
    Development of neuroepithelial bodies in pre- and postnatal mouse lungs: Scanning electron microscopic study (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 203 (1982), S. 285-291 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The development of pulmonary neuroepithelial bodies (NEBs) in pre- and postnatal mice were studied with scanning electron microscope. In the fetuses, at 17 days' gestation, the NEBs were recognized as slight epithelial elevations covered by developing Clara cells. At 18 days, the small apical surfaces of the specialized cells began to be exposed to the bronchiolar lumen. At 19 days (full term), numerous microvilli-covered surfaces of the specialized cells were located between the dome-shaped Clara cells. At this stage, the boundary of the NEBs was well outlined by the developing ciliated cells. In the postnatal animals, the surface structure of the specialized cells remained the same as that of the 19-day fetuses, but the modified Clara cells gradually became wide and flat. In older mice, some NEBs formed obvious spherical mounds projecting into the bronchiolar lumen. The rapid differentiation of the microvillar projections on the surfaces of the specialized cells shortly before birth should provide the animals ample surface area to make contact with the airway contents.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092030210
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  • 4
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of bronchiolar neuroepithelial bodies in neonatal mouse lungs (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 193 (1979), S. 913-925 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Scanning electron microscopy of the bronchiolar neuroepithelial bodies (NEB's) in the neonatal mouse lungs was undertaken and correlated with the accompanying transmission electron microscopy. The NEB's appeared as isolated organoids along the entire length of the bronchioles, and often were located at the branching points. The boundary of the NEB's was outlined by the ciliated and Clara cells. Both granulated cells and modified Clara cells participated in the formation of the NEB. The modified Clara cells covered most of the surface of the NEB leaving only small oval areas for the exposed surfaces of the specialized cells which contained numerous cytoplasmic granules. Short and regular microvilli projected from the exposed surfaces of the granulated cells, while only sparse microvilli of irregular length were seen on the surfaces of the modified Clara cells.This scanning electron microscopy of the NEB's further established these organoids as separate morphological entities. In addition, the findings that the NEB's could be easily identified with the scanning electron microscope and subsequently dissected out for further studies would help future investigations of their functions which are not clearly known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091930412
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  • 5
    Electronic Resource
    Electronic Resource
    Innervation of pulmonary alveoli of the mouse lung: An electron microscopic study (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 135 (1972), S. 477-495 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The nerve supply to the alveolar ducts and alveoli of mouse lungs was studied with the electron microscope. In the alveolar ducts, nerve bundles consisting of as many as nine unmyelinated axons surrounded by connective tissue fibers were usually located in the interstitium surrounding the openings of the alveoli. In the alveolar walls, nerve bundles consisting of as many as five unmyelinated axons were located in the interstitium between pneumocytes and the capillaries. The unmyelinated axons contained neurotubules and some mitochondria, and were partially or completely surrounded by Schwann cells. Two distinct types of enlarged nerve endings were identified. The first type contained many small mitochondria and was either associated with the type I pneumocyte or located alone in the interstitium. The second type was packed with numerous large dense-core vesicles and was in close contact with the type II pneumocyte. It is suggested that the first type of ending is sensory and the second type is motor in function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001350404
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  • 6
    Electronic Resource
    Electronic Resource
    Bronchiolar neuro-epithelial bodies in the neonatal mouse lungs (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 140 (1974), S. 191-199 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Bronchiolar neuro-epithelial bodies in neonatal mice were studied by light and electron microscopy. These bodies occurred in thickened areas of the epithelium, and consisted of groups of specialized, non-ciliated columnar epithelial cells with many cytoplasmic granules. These cells were usually closely parallel to one another and had elongated nuclei containing conspicuous peripheral chromatin condensations. These cells were associated with intra-epithelial axons.With electron microscopy, the non-myelinated axon under the neuro-epithelial body was observed to penetrate the basal lamina and enter the epithelial layer. After penetration, the intra-epithelial axon containing numerous mitochondria lost its Schwann cell sheath, became enlarged, and ramified among the epithelial cells.These innervated neuro-epithelial bodies probably function as sensory receptors in the bronchioles.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001400206
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  • 7
    Electronic Resource
    Electronic Resource
    Innervation of rabbit fetal lungs (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 159 (1980), S. 73-83 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Nerve fibers, autonomic ganglia, and neuroepithelial bodies of the lungs of rabbit fetuses, 17 to 31 days gestational age, were studied with neurohistological techniques including silver impregnation, acetylcholinesterase histochemistry, and glyoxylic-1acid-induced histofluorescence for monoamines.The silver impregnation method showed that nerve fibers and ganglia accompanied the bronchi and large pulmonary blood vessels to enter the developing lungs by the 17th day of gestation. Cholinergic and adrenergic nerves began to appear in the walls of the bronchi on the 21st day. The developing pulmonary arteries had accompanying adrenergic nerves on the 25th day. Acetylcholinesterase-positive parasympathetic ganglia were seen on the 27th day. Silver-impregnated nerve fibers in the developing alveolar walls and pleura were found on the 25th day.Neuroepithelial bodies and specialized single cells which were argyrophilic, acetylcholinesterase-positive, and fluorescent could be demonstrated in 19-21-day-old and older fetuses; and some of these structures were innervated by sensory and autonomic motor fibers. These observations indicated that nervous tissue and neuroepithelial bodies appeared in the lungs during the glandular stage of the lung development and that differentiation of adrenergic and cholinergic nerves began in the late glandular stage.
    Additional Material: 29 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001590107
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