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  • 1
    ISSN: 0005-2736
    Keywords: Bilayer hydration ; Fatty acid ; Membrane fusion ; Phase behavior ; Phosphatidylcholine ; Vesicle aggregation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Prostate cancer ; Chemotherapy ; 5-Fluorouracil ; Folinic acid ; Cell culture ; Tumor spheroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of cytotoxic chemotherapy for advanced, hormone-escaped prostate cancer have been disappointing. Evaluation of the effect of new drugs or new combinations with already known ones is required. The antimetabolite 5-fluorouracil (5-FU) has been shown to be active in prostate cancer, acting via inhibition of thymidylate synthase, an essential enzyme in DNA de novo synthesis. Experiments with cell lines of different tumors have shown that 5-FU activity can be modulated by addition of the coenzyme tetrahydrofolic acid (folinic acid). We investigated the effect of folinic acid and its stereoisomers on 5-FU action in different cell lines of prostate cancer. It was found that addition of non-toxic folinic acid led to a two- to fourfold better antiproliferative effect of 5-FU. The unnatural 6R isomer, which is a compound of chemically synthesized folinic acid, inhibited the modulatory effect of the natural 6S isomer. Our results indicated that a combination of folinic acid and 5-FU may result in a better response of patients with hormone-resistant prostate cancer than of patients treated with 5-FU alone.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 19 (1998), S. 59-62 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Prostatakarzinom ; Staging ; Grading ; Key words Prostate cancer ; Staging ; Grading
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Prostate cancer has become the most common cancer in males in Western countries. In the United States 317000 men were newly diagnosed with this disease in 1996. Screening efforts will identify increasing numbers of men who will be scheduled for prostate biopsy. Since the progression of prostate cancer varies widely from rapid tumor growth with early distant metastases to slow growth with good prognosis, it is of utmost importance that prognostic parameters be identified which allow the course of the disease to be predicted. Thus, the correct pathohistological staging, the evaluation of different grading systems, and the biological impact of positive surgical margins after radical prostatectomy requires collaboration between urologists and pathologists.
    Notes: Zusammenfassung Das Prostatakarzinom ist mittlerweile der häufigste Tumor des Mannes in den westlichen Industrieländern. In den USA wurde im Jahr 1996 ein solches Karzinom bei 317000 Männern diagnostiziert. Durch intensivierte Screeningbemühungen werden immer mehr Männer einer Prostatabiopsie zugeführt. Die Progression des Prostatakarzinoms reicht von einem schnellen Tumorwachstum mit frühzeitiger Metastasierung bis hin zu einem langsamen Wachstum mit guter Prognose. Aus diesem Grund ist es von großer Bedeutung, prognostische Parameter zu identifizieren, die eine Aussage zum Krankheitsverlauf ermöglichen. Neben der Identifizierung von Prognosefaktoren erfordert die korrekte pathohistologische Klassifizierung, die Evaluation von Gradingsystemen und die Beurteilung der biologischen Bedeutung positiver Absetzungsränder nach radikaler Prostatektomie die enge Kooperation zwischen Urologen und Pathologen.
    Type of Medium: Electronic Resource
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