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Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae (1994)

Yoshida, Satoshi ; Ohya, Yoshikazu ; Nakano, Akihiko ; [et al.]

Springer

Molecular genetics and genomics 242 (1994), S. 631-640

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ISSN: 1617-4623

Keywords: Staurosporine ; Phosphatidylinositol 4-kinase ; Protein kinase C ; Cell lysis ; Cell cycle

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Loss of yeast protein kinase C function results in three distinct phenotypes: staurosporine sensitivity, cell lysis and blockage of cell cycle progression at the G2/M boundary. Genetic analysis of the PKC1/STT1 protein kinase C gene and its interactions with STT4, encoding an upstream phosphatidylinositol 4-kinase, and BCK1, encoding a downstream protein kinase, reveal that they form part of a single pathway. However, the BCK1-20 mutation (a gain-of-function mutation of BCK1) or overexpression of PKC1 cannot suppress all of the phenotypes caused by the loss of STT4 function, strongly suggesting the existence of a branch point between STT4 and PKC1. We also describe the MSS4 gene, a multicopy suppressor of the temperature-sensitive stt4-1 mutation. MSS4 is predicted to encode a hydrophilic protein of 779 amino acid residues and is essential for cell growth. Based on genetic and biochemical data, we suggest that MSS4 acts downstream of STT4, but in a pathway that does not involve PKC1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00283416

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Theoretical prediction of minima in association constants for complex formation between alkylviologens and indole derivatives in the presence of polyelectrolytes (1987)

Ishiwatari, Tsutomu ; Yoshida, Satoshi ; Morita, Mariko ; [et al.]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 25 (1987), S. 263-277

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ISSN: 0887-6266

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Association constants K for the complexation between various alkylviologens (methyl, propyl, butyl, pentyl, and hexyl) and indole derivatives (acetate and butyrate) have been determined. The order of K values indicates the important role of hydrophobic interactions in aiding the formation of charge transfer complexes. Influences of two kinds of polyelectrolytes; i.e., potassium polystyrenesulfonate (KPSS, anionic) and 3,3-ionene (cationic) on the K values were also examined. KPSS decreased the K value but, interestingly, yielded a minimum, and the K value increased at high KPSS concentrations. The influence of the type of alkylviologen on the K versus [KPSS] plots was successfully understood by a theory of substrate partitioning between bulk water and the environment of the polymer.

Additional Material: 13 Ill.