ISSN:
1432-2072
Keywords:
Central Nicotinic Convulsions
;
Central Nicotinic Receptors
;
Central Antinicotinic Activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Intracerebral administration of nicotine in mice produces convulsions without any deaths in doses which are significantly lower than the parenteral doses. The drug seems to act on central nicotinic receptors. The antagonism of central nicotinic convulsions was thus employed for the measurement of the central antiicotinic activity of various CNS acting agents. Chlorisondamine was found to be the most potent, and next in order were atropine and chlorpromazine. It is suggested that the method forms a simple test for evaluating the central antinicotinic activity of various CNS acting agents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00403704
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