ISSN:
1432-1106
Keywords:
Serotonin
;
Estradiol
;
Brain nuclei
;
Raphe
;
Hydroxyindole acetic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Increased serotonin content of the dorsal raphe nucleus and of the substantia nigra were seen following acute (12 h or 24 h) administration of 17β-estradiol to ovariectomized rats. No changes were seen in numerous other nuclei of forebrain or hindbrain, and no changes occurred during chronic (1 month) estradiol administration. Changes in the concentration of the major serotonin metabolite, 5-hydroxyindole acetic acid, paralleled those of serotonin. These results show that, under precisely defined conditions and in specific locations only, estradiol can modulate serotonergic neuronal systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00236804
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