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  • 1
    ISSN: 1432-0878
    Keywords: Haemocytes ; Glia ; Central nervous system ; Repair ; Insect ; Periplaneta americana
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Injection of physiologically inert particles (fluorescent microspheres) has a profound effect on neural repair of central nervous connectives of the cockroach Periplaneta americana following selective glial disruption. The injected particles, which do not gain direct access to the central nervous tissues, are taken up by a relatively small proportion (〈 10%) of the haemocytes. This interference with haemocyte function virtually abolishes the appearance of the granule-containing cells (which are prominently involved in normal glial repair) and produces abnormal reorganization of the superficial glial elements. These results are interpreted as evidence that the granule-containing cells are derived from haemocytes which are critically involved in glial repair.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0878
    Keywords: Glia ; Haemocyte ; Central nervous system ; Bleomycin ; Neural repair ; Insect, Periplaneta americana
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The DNA-binding drug, bleomycin, has a profound effect on neural repair following selective glial disruption by ethidium bromide. The contribution of the granule-containing cells (which normally appear in the early stages of repair) is greatly reduced, the restoration of the blood-brain barrier is delayed and the ultrastructural organization of the reorganising perineurium is dramatically changed. The aberrant perineurial structure and function observed in the presence of bleomycin are postulated to result from the effects of the drug on haemocytes which, together with endogenous reactive cells, contribute to the normal process of glial repair.
    Type of Medium: Electronic Resource
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