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  • Cerebellar cortical atrophy  (1)
  • Cobaltporphyrin  (1)
  • Endocytosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Spinocerebellar ataxia type 6: MRI of three Japanese patients (1998)
    Springer
    Neuroradiology 40 (1998), S. 222-227 
    Details
    ISSN: 1432-1920
    Keywords: Key words Spinocerebellar ataxia type 6 ; Cerebellar cortical atrophy ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the MRI findings in three Japanese patients with spinocerebellar ataxia type 6 (SCA6) in which a polymorphic CAG repeat was identified in the gene encoding the α1A voltage-dependent P/Q-type Ca2+ channel subunit (CACNL1A4). All showed slowly progressive cerebellar ataxia and mild pyramidal signs. Neuroradiologically, they had moderate cerebellar atrophy, most prominently in the superior vermis, whereas the brain stem appeared to be spared. No abnormal signal intensity was identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050571
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rearrangement of the open-canalicular system of the human blood platelet after incorporation of surface-bound ligands (1986)
    Springer
    Cell & tissue research 245 (1986), S. 465-469 
    Details
    ISSN: 1432-0878
    Keywords: Platelet ; Cationized ferritin ; Endocytosis ; Open-canalicular system ; High-voltage electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional configuration of the membrane system in human blood platelets following administration of cationized ferritin (CF) was reconstructed by means of thick serial sectioning in combination with high-voltage electron microscopy (HVEM). Surface-bound CF was rapidly internalized at 37 ° C by the platelets, and a conglomerate of vacuolar and tubular structures containing CF was formed in their interior. Three-dimensional reconstruction of these incorporated membranous structures revealed that most of the internalized structures were interconnected with each other and that the number of sites at which they opened onto the cell surface was significantly reduced compared with the number found in intact platelets. In some cases, the openings completely disappeared. This may indicate that most of the internalized membranous structures originate from the open canalicular system (OCS), and that, following the incorporation of the ligand, the OCS gradually loses its connections with the surface membrane forming a conglomerate of the ligand-containing membranous structures in the interior of the platelet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218545
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Oxygen dissolution and transport in cobaltporphyrin-bound organophosphazene membranes (1993)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 4 (1993), S. 17-20 
    Details
    ISSN: 1042-7147
    Keywords: Poly(organophosphazene) ; Cobaltporphyrin ; Facilitated transport ; Oxygen-separating membrane ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Rubbery poly(organophosphazene)s were synthesized, and were combined with cobaltporphyrin (CoP) which binds molecular oxygen rapidly and reversibly. The apparent oxygen-binding equilibrium constant (Kapp) is in proportion to the physical solubility coefficient of oxygen in the polymer, although the reduced equilibrium and thermodynamic parameters are not dependent on the polymer matrix species. Diffusivity of oxygen via the fixed CoP(DC) is enhanced for poly(organophosphazene) membranes with a larger oxygen diffusion constant. Poly(organophosphazene) membranes with both a large Kapp and DC yield high oxygen permeability.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1993.220040104
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    Paper (German National Licenses)
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