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  • Development  (2)
  • Cerebellar ontogeny  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Different effect of methylazoxymethanol on mouse cerebellar development depending on the age of injection (1985)
    Springer
    Experimental brain research 57 (1985), S. 279-285 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Cerebellum ; Development ; Methylazoxymethanol ; Mouse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Methylazoxymethanol (MAM), a powerful antimitotic, has been extensively used to affect rodent CNS development. Here we show that MAM causes different effects on mouse cerebellum depending on the age of the injected pup. Sublethal doses were determined for each age. A single injection at birth permanently reduces the number of cells. In addition, the cytoarchitecture was greatly perturbed: Purkinje cells retained an immature aspect and were dispersed through the cerebellar cortex. A single dose of MAM injected into 5 day old mice also affected the number of cells but, at the level of light microscopy, the cytoarchitecture of the cerebellar cortex appeared not to be altered. Purkinje cells, however, showed some immaturity and degenerated around the 22nd postnatal day. This modulation of MAM effect appears to provide a good model for studying cerebellar ontogeny and neuronal plasticity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236533
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  • 2
    Digitale Medien
    Digitale Medien
    Ectopic granule cell layer in mouse cerebellum after methyl-azoxy-methanol (MAM) treatment (1991)
    Springer
    Experimental brain research 86 (1991), S. 90-96 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Development ; Immunohistochemistry ; Mouse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Previous results from our laboratory (Bejar et al. 1985) indicated that a single injection in mouse pups of the antimitotic/mutagenic agent methylazoxymethanol at postnatal day 5 typically produces hypogranular cerebella with no changes in foliation, in contrast to the severe alterations observed after the more usual injection on the day of birth. Here we report that injection of a higher dose (30 mg/kg) of methylazoxymethanol, always at postnatal day 5, leads to the additional presence of a ectopic cell layer in adult cerebellum. Immunostaining with several antibodies recognizing cell specific proteins ruled out the possibility that these ectopic cells were glial and electron microscopy indicated that they were morphologically mature granule cells. In the molecular layer of other cerebellar areas and apparently unrelated with granule cell ectopia, ectopic Golgi epithelial cells were observed. The reason for the presence of these ectopic cells of different type in the molecular layer was discussed in relation with analogous ectopias obtained by other means.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00231043
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  • 3
    Digitale Medien
    Digitale Medien
    Differential ontogenic pattern of metabotropic [3H]-l-glutamate receptors in normal and granule cell-deficient mouse cerebellum (1996)
    Springer
    Experimental brain research 107 (1996), S. 361-366 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Metabotropic glutamate receptors ; Cerebellar ontogeny ; Methylazoxymethanol ; Mouse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract [3H]-l-glutamate binding site distribution corresponding to metabotropic receptors was studied by autoradiography during normal and altered cerebellar ontogeny in mice treated on postnatal days (PND) 5 and 6 with the antimitotic methylazoxy-methanol (MAM). Quisqualate (QA)-induced and (2S, 3S, 4S)-α-(carboxycyclopropyl)-glycine (L-CCG-I)-induced [3H]-l-glutamate binding inhibition allowed us to distinguish between group I and group II metabotropic receptor binding sites. In control cerebellar cortex, the QA-sensitive binding site density increases during development, while the L-CCG-I-sensitive binding site density decreases. In the deep cerebellar nuclei (DCN), both populations of binding sites decrease during ontogeny. The antimitotic treatment induces: (1) a slight but significant increase in the QA-sensitive binding sites in the DCN at PND 10 and in the cerebellar cortex beginning from PND 20; (2) a retarded decrease in the L-CCG-I-sensitive metabotropic receptor binding site density. These differences could be due to a retarded cell maturation and/or an over-expression of some postsynaptic receptors in the adult cerebellum in response to the afference deficiency.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00230418
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