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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1987), S. 122-124 
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Hodgkin's disease ; MRI ; Anti-Purkinje-cell antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of paraneoplastic cerebellar degeneration (PCD) associated with Hodgkin's disease is presented. The features that make this case particularly interesting are the simultaneous occurrence of PCD with a relapse of Hodgkin's disease, which has been present for 17 years, and the arrested progression of cerebellar dysfunction after a subacute onset. Cerebellar atrophy was revealed by computed tomography and magnetic resonance imaging. In contrast to two previously reported cases, anti-Purkinje-cell antibodies were not detected.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 226 (1978), S. 183-199 
    ISSN: 1433-8491
    Keywords: Fixation suppression of VOR ; Optokinetic nystagmus ; Cerebellum ; Fixationssuppression des vestibulären Nystagmus ; Optokinetischer Nystagmus ; Cerebellum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Suppression des vestibulären Nystagmus durch Fixation während sinusförmiger Körperdrehung um die vertikale Achse bei einer Frequenz von 0, 1 Hz und einer Maximalbeschleunigung von +-10 bis 130°/s2 untersucht. Die Gesamtamplitude des vestibulären Nystagmus in einer Richtung während des Versuches der Unterdrückung durch Fixation wurde mit der Güte der langsamen Phasen des optokinetischen Nystagmus, gemessen an deren Gesamtamplitude, und der Güte von Folgebewegungen, gemessen an der Gesamtamplitude von eingestreuten Saccaden, verglichen.
    Notes: Summary The suppression of vestibular nystagmus (VN) by fixation of a small visual target moving with the observer was tested while subjects seated on a rotatable chair were oscillated at 0.1 Hz and peak accelerations of +-10 to 130°/s2. Total amplitudes of nystagmus during movement towards one direction occurring despite intended fixation were compared to slow phases of optokinetic nystagmus (OKN) and smooth pursuit (SP) towards the opposite direction.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 228 (1980), S. 135-150 
    ISSN: 1433-8491
    Keywords: Posture ; Quantitative evaluation ; Cerebellum ; Standstabilität ; Quantitative Auswertung ; Kleinhirn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden Methodik und Parameter für eine quantitative Auswertung der Standunruhe bei Kranken und Gesunden beschrieben. Aus den Analogsignalen einer Kraftmeßplattform werden die folgenden Daten über die Bewegungen des Körperkraftschwerpunktes digital errechnet: Schwingungsweg (SP), dessen mittlere Amplitude (MA), mittlere Frequenz (MF), die lateralen und sagittalen Komponenten, deren Quotienten und die von den Körperschwankungen umschlossene Fläche (SA). Quotienten der Werte bei offenen und geschlossenen Augen beschreiben die visuelle Standstabilisation. Positions- und Richtungshistogramme dokumentieren zusätzlich die Vorzugsrichtungen der Körperunruhe. Eine Analyse der Signifikanz dieser Parameter zeigte trotz großer Varianz bei Normalen deren klinische Brauchbarkeit. Patienten mit Kleinhirnerkrankungen (vorwiegend des Vorderlappens) zeigen bis zu 10mal höhere Werte, z. B. für MA und SP vorwiegend in sagittaler Richtung und eine erhöhte mittlere Frequenz (MF), während Patienten mit weitgehend kompensierten Vestibularisläsionen nur bei geschlossenen Augen vermehrt schwanken, wobei MF erniedrigt ist.
    Notes: Summary Methods and parameters are described to quantify body sway as measured by a force-transducing platform. Analogue data representing the coordinates of the body's center of force (COF) are fed into a digital computer. The following parameters are then calculated and tested for their diagnostic significance: sway path (SP), mean amplitude of sway (MA), mean sway frequency (MF), their lateral and sagittal components, and the quotients sagittal/lateral of these as well as the sway area (SA) circumscribed by the COF. Quotients of eyes open/eyes closed for all these parameters determine the visual stabilization of posture. Sway position and sway direction histograms allow for a more detailed analysis of MA and SP. Despite considerable inter and intraindividual variance of these parameters (in 28 normals), some of them seem of clinical significance not only for documentation and follow-up studies but also for differential diagnosis. In patients with cerebellar lesions (n=12), SP and MA were up to 10 times larger with a marked antero-posterior instability, MF being above normal. Patients with labyrinthine lesions (n=10) showed significant instability only with eyes closed, MF being slightly below normal.
    Type of Medium: Electronic Resource
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