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  • 1
    Electronic Resource
    Electronic Resource
    Early management in poor grade aneurysm patients (1994)
    Springer
    Acta neurochirurgica 126 (1994), S. 33-37 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral aneurysm ; poor grade aneurysm ; early management ; outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aneurysm surgery began in Lübeck only in 1986 when the department was completely reorganized. Early operation in the good grade patients (I–III, according to Hunt and Hess) was performed. In every case we also discussed the feasibility of operating on the poor grade patients (Hunt and Hess IV and V). During a five-year period (1986–1991) a total of 277 SAH patients were admitted to the department. 109 (39%) patients arrived in a poor grade (Hunt and Hess IV or V), 12 of these patients died within hours of admission. 25 patients, who presented with a large intracerebral and/or subdural haematoma, were urgently operated upon by haematoma evacuation and aneurysm clipping. An external ventricular drainage was performed on 72 patients. Of the ventriculostomy group 33 patients improved and 27 were operated upon. In 17 of the 39 patients without improvement after CSF-drainage we decided to operate. Overall 69 patients were surgically treated (craniotomy, aneurysm clipping) and 40 were not. The mortality rate in the surgical cases was 16 (23%) compared with 30 (75%) without operation. It is concluded that poor grade aneurysm patients can achieve a better outcome with active treatment based on immediate ventriculostomy and optimal haemodynamic parameters after haematoma evacuation and early occlusion of the aneurysm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476491
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  • 2
    Electronic Resource
    Electronic Resource
    Acute subdural haematoma from ruptured intracranial aneurysms (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 163-167 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral aneurysm ; acute subdural haematoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute subdural haematoma (SDH) secondary to a raptured intracranial aneurysm is a rare event. Out of a total of 292 patients with a verified aneurysm (period 1986–1992) in five cases SDH was the diagnosis on CT-evaluation. One patient was in such a bad condition that no treatment was indicated. The remaining four patients were operated on: craniotomy and haematoma evacuation in two cases, craniotomy for haematoma evacuation and aneurysm-clipping in the other two cases. Two patients died and two achieved a good outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410620
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  • 3
    Electronic Resource
    Electronic Resource
    Total Synthesis of Indole and Dihydroindole Alkaloids. IXFor a preliminary report on a portion of this work, see [1].Part VIII, see [2]. Studies on the synthesis of bisindole alkaloids in the vinblastine- vincristine series. The biogenetic approach (1976)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 59 (1976), S. 2858-2882 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A detailed study of the reaction of catharanthine N-oxide and vindoline has been carried out employing various conditions. Under optimum conditions, which involve low temperatures and trifluoroacetic anhydride as reagent, 3′, 4′-dehydrovinblastine (XIII, R = COOCH3), in reasonable yields is essentially the exclusive product. However two additional products, 18′ (epi)- 3′, 4′-dehydrovinblastine (XIV, R = COOCH3) and 1′-hydroxy- 3′, 4′-dehydrovinblastine (XVI, R = COOCH3) are also often isolated.The reaction, which follows the course of a Polonovski-type fragmentation process, has been extended to the N-oxide derivatives of dihydrocatharanthine and decarbomethoxycatharanthine to provide again a series of bisindole alkaloid derivatives, also vinblastines. A mechanistic rationale is provided to explain the various results obtained.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19760590824
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  • 4
    Electronic Resource
    Electronic Resource
    Die Darstellung höherer Alkylrhodanide. (Nachtrag) (1940)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 156 (1940), S. 260-260 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19401560902
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  • 5
    Electronic Resource
    Electronic Resource
    Präparative und spektroskopische Untersuchungen an SilylperoxydenHerrn Professor Dr. W. Langenbeck zum 60. Geburtstage gewidmet (1959)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 8 (1959), S. 241-255 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es werden spektroskopische Untersuchungen zur Strukturaufklärung von Siliciumperoxyden durchgeführt, einer neuen Verbindungsklasse, deren Erforschung im Rahmen der Entwicklung der peroxydischen Polymerisationskatalysatoren und Aktivatoren Bedeutung zukommt.Dabei wurden die IR- und Raman-Spektren der folgenden Präparate aufgenommen und untersucht: \documentclass{article}\pagestyle{empty}\begin{document}$$ \left({{\rm CH}_{\rm 3} } \right)_3 {\rm SiOOSi}\left({{\rm CH}_{\rm 3} } \right)_3,\left({{\rm CH}_{\rm 3} } \right)_3 {\rm SiOOC}\left({{\rm CH}_{\rm 3} } \right)_3,\left({{\rm CH}_{\rm 3} } \right)_3 {\rm COOC}\left({{\rm CH}_{\rm 3} } \right)_3,\left({{\rm C}_{\rm 2} {\rm H}_{\rm 5} } \right)_3 {\rm SiOOSi}\left({{\rm C}_{\rm 2} {\rm H}_{\rm 5} } \right)_3 $$\end{document} Es werden allgemeine Strukturbetrachtungen für Moleküle des Typs R3XOOXR3 als Viermassenmodell durchgeführt. Bei der Zuordnung der Spektren werden jeweils Vergleichssubstanzen herangezogen, die die Gruppierung R3X -  mit dem entsprechenden Peroxyd gemeinsam haben, um durch Aussonderung der Frequenzen des R3X-Gerüstes die Schwingungen der XOOX-Brücke isolieren zu können. Dabei kann als wahrscheinlichste Struktur für die Verbindungen des Typs R3SiOOSiR3 und R3COOCR3 ein wasserstoffperoxydähnlicher Bau der Moleküle abgeleitet werden. Diese Deutung wird durch die Tatsache gestützt, daß andere Bearbeiter mit Hilfe von Messungen elektrischer Momente zu ähnlichen Aussagen über den Molekülbau des Di-tert.-Butylperoxyds gelangen.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19590080501
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    Paper (German National Licenses)
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