ISSN:
1619-7089
Keywords:
Positron emission tomography
;
Fluorine-18 fluorophenylalanine
;
Cerebral gliomas
;
Large neutral amino acid transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To elucidate the mechanism of large neutral amino acid (LNAA) transport in cerebral gliomas and to evaluate the clinical usefulness of positron emission tomography (PET) with fluorine-18 fluorophenylalanine (18F-Phe), we examined 18 patients with cerebral glioma using dynamic PET and18F-Phe. By employing two-compartment model analysis, the influx rateK 1, the efflux ratek 2 and the distribution volume (V d) of18F-Phe were estimated in tumour tissue and contralateral normal grey matter.18F-Phe showed increased accumulation in tumour tissue regardless of the grade of malignancy in all patients. The rate of uptake of18F-Phe in high-grade glioma was significantly higher than in low-grade glioma (P 〈0.05). However, it was difficult to evaluate the tumour grade only from the18F-Phe accumulation in individual cases. Values ofK 1 andV d were significantly increased in the tumour tissue. TheK 1 value of the tumour tissue tended to decrease with increasing LNAA concentration in plasma. Therefore, influx of18F-Phe into tumour tissue is mainly related to the carrier-mediated active transport. It is concluded that PET with18F-Phe is of clinical value for tumour detection rather than assessment of tumour malignancy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01084361
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