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  • 1
    Electronic Resource
    Electronic Resource
    Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 158-163 
    Details
    ISSN: 1619-7089
    Keywords: S2 serotonin receptors ; Fluoroethylspiperone ; Positron emission tomography ; Neuroreceptor modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P 〈0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262725
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of pathophysiology of stroke by positron emission tomography (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 455-465 
    Details
    ISSN: 1619-7089
    Keywords: Ischaemic stroke ; Positron emission tomography ; Cerebral blood flow ; Cerebral oxygen consumption ; Cerebral glucose metabolism ; Oxygen extraction fraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In stroke patients, multitracer positron emission tomography (PET) permits the assessment of acute changes in regional cerebral blood flow (rCBF), blood volume (rCBV), oxygen consumption (rCMRO2) and glucose metabolism (rCMRgl), which are the initial steps in the complex molecular and biochemical process leading to ischaemic cell damage. While early infarcts exhibit low flow and oxygen consumption, increased oxygen extraction fraction (OEF) due to preserved metabolism at reduced flow suggests viability of tissue. However, most initially “viable” tissue will be metabolically deranged and will become necrotic in the further course; only in a few instances do these tissue compartments recover to normal function. Increased glucose uptake at reduced oxygen supply induces non-oxidative glycolysis with noxious lactacidosis, whereas hyperperfusion beyond the metabolic demand is of controversial effect. In subacute or chronic states after ischaemia reduced flow can be compensated by increased blood volume; when perfusional reserve is exhausted, oxygen extraction increases. Such findings may guide therapeutic decisions and predict the severity of permanent deficits. Functional deactivation of tissue remote from the lesion is found regularly as a sign of damaged connecting pathways. Flow and metabolic studies during the performance of specific tasks help to detect alternative functional loops and may yield prognostic information. Repeat studies in the course of stroke are employed for the evaluation of therapeutic strategies targeted to improve reperfusion or to effect metabolic or biochemical alterations. In the future PET may gain additional clinical importance when patients are selected for elective treatment according to the prevailing pathophysiological pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171424
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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