ISSN:
1432-2013
Keywords:
Oxygen consumption
;
Histological techniques
;
Kidney
;
Cervix uteri
;
Neoplasms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A technique has been used to measure distributions of oxygen removal rate,Q R in samples of recently excised tissue whereQ R is defined as the ratio of the oxygen uptake rate to the oxygen solubility.Q R was measured at 91 sampling points across a cross section of tissue of diameter 5 mm. By placing markers in the tissue and using special procedures to obtain sections of the tissue samples it was possible to compare the distributions ofQ R with the histological structure of the tissues. The overall resolution of the system is about 1/2 mm so that structures of the order of a millimetre or more could be examined. There are considerable inhomogeneities inQ R within some normal tissues, for example 4–19 mm Hg/s in rat kidney and 0.4–1.5 mm Hg/s in human cervix. Inhomogeneities in tumour tissues are also associated with the histological structure and examples for the Lewis lung mouse carcinoma show a correlation betweenQ R and regions of viable or necrotic tissue. For a biopsy sample of human carcinoma of the cervixQ R correlates with the degree of local infiltration by tumour cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00584853
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