ISSN:
1432-1017
Keywords:
Ion-channel interaction
;
Gramicidin
;
Electrostatic model
;
Channel conductance
;
Residue substitution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract A model based on the solution of the electrostatic potential for a geometry of three dielectric regions associated with a gramicidin A channel (GA) is presented. The model includes a cylindrical dielectric layer to represent the peptide backbone and dipole rings to account for dipolar side chains. Image potential and dipolar contributions for different orientations and positions along the channel are analyzed. The conductance of GA and two analogues obtained by substituting the amino acid at position 1 are studied. The numerical simulation reproduces experimental results (Barrett et al. 1986, Biophys J 49, 673–686) and supports the idea that electrostatic dipole-ion interactions are of primary importance in gramicidin channel function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180264
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