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  • 1
    Electronic Resource
    Electronic Resource
    Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
    Amsterdam : Elsevier
    Mutation Research DNAging 295 (1993), S. 201-222 
    Details
    ISSN: 0921-8734
    Keywords: Caloric restriction ; Cytochrome P450 ; Drug metabolism
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8734(93)90021-T
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  • 2
    Electronic Resource
    Electronic Resource
    Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters (1996)
    Springer
    Archives of toxicology 70 (1996), S. 202-208 
    Details
    ISSN: 1432-0738
    Keywords: Key words Diabetes ; Cytochrome P450 ; Monooxygenase ; Hamster ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The acute and chronic effects of streptozotocin diabetes on kidney and liver microsomal monooxygenases were studied using hamsters 2 days and 6 weeks following treatment with the diabetogen, respectively. Acute diabetes increased aniline hydroxylation and N-nitrosodimethylamine demethylation, decreased pentoxyresorufin O-dealkylation, without affecting benzo(a)pyrene hydroxylation and 7-ethoxycoumarin O-deethylation in kidney and liver microsomes. The effects of chronic diabetes on the microsomal monooxygenases were similar to the effects of acute diabetes, except that the chronic diabetic condition markedly decreased benzo(a)pyrene and 7-ethoxycoumarin oxidations in kidney microsomes. Total cytochrome P450 content and NADPH-cytochrome P450 reductase activity in kidney and liver microsomes of the diabetic hamsters were similar to the controls. Gel electrophoresis of microsomes from control and streptozoptocin treated hamster tissues revealed that diabetes enhanced the intensity of protein band(s) in the P450 molecular weight region. Immunoblotting of microsomal proteins showed that acute and chronic streptozotocin diabetes induced proteins immunorelated to P450s 2E1 and 1A in kidney and liver. In marked contrast, the acute and chronic diabetic conditions decreased the level of a P450 2B-immunorelated protein(s) in kidney and liver. The present study demonstrates that acute and chronic streptozotocin diabetes has the ability to induce P450 2E1 and 1A and suppress P450 2B in hamster kidney and liver and that the hamster monooxygenase responds to diabetes differently from the rat enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050261
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  • 3
    Electronic Resource
    Electronic Resource
    Numerical simulation of semicrystalline polymer flowing in an empty tube with solidification (1992)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 724-731 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A methodology is set forth for the numerical solution of the transient freezing problem of a viscous power-law fluid flowing in a cold empty tube with a frozen layer forming on the inside tube surface. The fluid considered is the melt of a semicrystalline polymer with temperature dependent viscosity. The solution domain encompasses both the liquid and solid phases. Coordinate transformations are employed to immobilize and to straighten the moving, curved interface. An implicit finite difference method is employed to solve the governing equations. Numerical results are analyzed by examining the effects of the Peclet number, Nahme number, Stefen number, and the power law index on the profiles of the frozen layer. Variations of the thickness of the frozen layer as a function of time and axial coordinate are also presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760321104
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  • 4
    Electronic Resource
    Electronic Resource
    Fickian diffusion of alkanes through glassy polymers: Effects of temperature, diffusant size, and polymer structure (1980)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 20 (1980), S. 40-50 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Diffusivities D ranging over six orders of magnitude with values as low as 2 × 10-13 cm2/s have been obtained by a recently developed permeation apparatus, employing a gas-flow method and a flame ionization detector; Log D for hydrocarbons in bisphenol-A polycarbonate (PC) at 120°C is proportional to the square of the molecular diameter (d2) as given by the Lennard-Jones 6-12 potential. This correlation holds even for the nonspherical n-hexane molecule. The activation energy for diffusion is also linearly related to d2, with values of 9.5 and 23 kcal/mol for methane and neopentane in PC, respectively. Comparison of PC with two similar polymers of higher glass-transition temperatures (Tg) indicates that our diffusion data do not correlate with the Tg of these polymers. The presence of subsidiary transitions, however, appears to enhance segmental mobilities, increasing the rate of diffusion of the hydrocarbons. The thermodynamic solubility of alkanes in glassy PC can be directly related to their boiling points, and in addition, their enthalpy of solution is linearly related to the heat of condensation of these permeants.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760200108
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental investigation of the polymer melt flow during injection post-filling process (1995)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 2661-2663 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690411217
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  • 6
    Electronic Resource
    Electronic Resource
    Study of polymer melt flow in sequential injection molding process (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 1706-1714 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Experimental studies of polymer melt flow in the filling and post-filling stages of the injection molding process were performed using the sequential injection of transparent and colored polystyrene resin. Effects of fountain flow in the filling stage, geometrical factors caused by edges and corners, as well as flow through contractions and expansions, were identified. Significant polymer melt flow which increases with increased packing pressure was observed in the post-filling process. The melt flow is more concentrated around the gate area than away from the gate. It was also found that the polymer melt flows across the gap center, resulting in partial annihilation of the weld line. Simulations based on the control-volume/finite-element method employed within each gapwise layer combined with the dual-filling-parameter technique were developed to trace the advancements in melt fronts for both skin and core materials. Numerical simulations show reasonable consistency with experimental results in both skin and core material distribution. If the edge effect is taken into account using a shape factor as a geometrical correction, the simulation accuracy is further improved.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690420622
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  • 7
    Electronic Resource
    Electronic Resource
    Tracer diffusion in dense ethanol: A generalized correlation for nonpolar and hydrogen-bonded solvents (1986)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 32 (1986), S. 1367-1371 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Tracer diffusion coefficients were measured for benzene, toluene, mesitylene, naphthalene, and phenanthrene in dense ethanol at 0.56 ≤ TR ≤ 1.07 and ρR ≥ 1.44. The results were used to examine the temperature dependence of the degree of association between ethanol molecules across the entire range of temperature. The hard-sphere tracer diffusion equation and the Stokes-Einstein equation were used to develop two engineering correlations. The former approach was found to be adequate for solvents of relatively compact molecules, and the latter to be more general in its applications. The absolute deviation of prediction from observed values of tracer diffusivities is 4%, with a maximum error of 13%.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690320814
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  • 8
    Electronic Resource
    Electronic Resource
    An evaluation of the lamellar stretch description of mixing with diffusion and chemical reaction (1986)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 32 (1986), S. 1043-1048 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690320616
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  • 9
    Electronic Resource
    Electronic Resource
    The mixing of solid particles in a motionless mixer - a stochastic approach (1972)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 18 (1972), S. 984-989 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A Markov chain model was used to model the axial mixing of solid particles in a motionless mixer having no moving parts. One step transition probabilities were determined experimentally for the model. Based on these transition probabilities, the model was able to predict spatial distribution of tracer particles up to seven steps of the Markov chain, which was equivalent to seven consecutive passes of the mixture through the mixer. Experimental results were in good agreement with those predicted from the Markov chain model.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690180515
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  • 10
    Electronic Resource
    Electronic Resource
    Diffusion of benzene, toluene, naphthalene, and phenanthrene in supercritical dense 2,3-dimethylbutane (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 1904-1910 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The conditions under which the Taylor-Aris dispersion phenomenon can be employed to generate accurate tracer diffusion data in supercritical dense fluids are established. The technique is used to determine the diffusivities of benzene, toluene, naphthalene, and phenanthrene in supercritical dense 2,3-dimethylbutane as a function of temperature and pressure. A molecular theory incorporating the Sung-Stell formulation of molecular dynamic correlations in smooth-hardsphere fluids and the Baleiko-Davis molecular roughness for polyatomics with the Enskog-Thorne dense gas diffusivity relationship is found to represent our experimental data to within ±4%. The values of the effective hard-sphere diameters involved in the present theory can be predicted fairly accurately from the critical volumes of the solutes and solvent considered here.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690311115
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