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  • Polymer and Materials Science  (45)
  • Chemical Engineering  (9)
  • Lepidoptera  (7)
  • Drug discrimination  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Changes of sensitivity to the cuing properties of narcotic drugs as evidenced by generalization and cross-generalization experiments (1978)
    Springer
    Psychopharmacology 58 (1978), S. 257-262 
    Details
    ISSN: 1432-2072
    Keywords: Fentanyl ; Morphine ; Narcotic cue ; Sensitivity ; Oscillation ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With a discrete-trial, food-reward, two-lever procedure, rats were trained to discriminate 0.04 mg/kg fentanyl from saline. Individual threshold doses for seneralization of fentanyl and for cross-generalization of morphine were determined repeatedly during a 17-week posttraining period. Threshold doses of both drugs almost continuously shifted in both the up- and downward direction. Shifts of fentanyl threshold doses covaried with those of morphine threshold doses. These shifts can best be described by a sustained oscillation, the mean amplitude of which amounts to a factor 3.65 of the dose-range for fentanyl, and to a factor 1.85 for morphine. The upper and lower limits of oscillation were symmetrical with respect to baseline. The oscillation can be described by a function expressing that the more distant a point along the function is from the baseline, the more it is susceptible to (positive/negative) acceleration along the intensity (i.e., dose) axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427388
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  • 2
    Electronic Resource
    Electronic Resource
    Neuroleptic interference with the cocaine cue: Internal stimulus control of behavior and psychosis (1978)
    Springer
    Psychopharmacology 58 (1978), S. 247-255 
    Details
    ISSN: 1432-2072
    Keywords: Cocaine ; Haloperidol ; Pimozide ; Spiperone ; Internal stimulus ; Drug discrimination ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of cocaine to exert internal stimulus control of behavior was investigated by training rats to discriminate 10 mg/kg cocaine from saline in a discrete-trial, two-lever, food-reward procedure. Acquisition of response control by cocaine (1) succeeded in all animals tested, (2) proceeded rapidly, and (3) was associated with a high Commission Error: Omission Error ratio. These findings support the hypothesis that cocaine, a prototype of drugs inducing a psychotic condition in humans, can act as a powerful internal stimulus in rats. The cocaine cue was also responsive to the action of the dopamine-receptor-blocking agents spiperone (ED50: 0.06 mg/kg), haloperidol (0.24 mg/kg), and pimozide (1.90 mg/kg). d,l-Amphetamine (1.25 mg/kg) induced stimulus generalization with cocaine, and this generalization was blocked by dosages of the same neuroleptics comparable to those of cocaine antagonism. The results are discussed in terms of internal stimulus control of behavior and its relevance to the psychophysiology of schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427387
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  • 3
    Electronic Resource
    Electronic Resource
    Narcotic cuing and analgesic activity of narcotic analgesics: Associative and dissociative characteristics (1978)
    Springer
    Psychopharmacology 57 (1978), S. 21-26 
    Details
    ISSN: 1432-2072
    Keywords: Fentanyl ; Narcotic cue ; Analgesia ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract By using a discrete-trial, two-lever, food-reinforced discrimination learning paradigm, rats were trained to discriminate the narcotic analgesic fentanyl (0.04 mg/kg) from saline. Stimulus generalization experiments with lower fentanyl doses (0.0025 to 0.02 mg/kg) were carried out to generate individual threshold doses. The latter were compared with the sensitivity of the same rats to the analgesic effect of fentanyl, and it was found that there is no correlation between these two sets of data. In a time-effect experiment, the duration of fentanyl's cuing effect was compared with that of its analgesic effect, and it was found that the time-effect characteristics of the narcotic cue are similar to those of analgesia. Again, however, there was no correlation between the duration of both effects within the same group of animals. The results further deliniate the associative and dissociative characteristics of the narcotic cue and narcotic analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426952
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  • 4
    Electronic Resource
    Electronic Resource
    Agonist and antagonist effects of prototype opiate drugs in fentanyl dose-dose discrimination (1986)
    Springer
    Psychopharmacology 90 (1986), S. 222-228 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Dose-dose discrimination ; Opiates ; Fentanyl ; Morphine ; Naloxone ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The experiments characterized the effects of fentanyl, morphine, naloxone, cyclazocine, nalorphine, ketocyclazocine and N-allylnormetazocine in rats that were trained to discriminate 0.04 mg/kg from 0.02 mg/kg fentanyl (dose-dose discrimination). The data are compared to results obtained previously in rats discriminating 0.04 mg/kg fentanyl from saline (drug-saline discrimination). In the dose-dose discrimination fentanyl and morphine produced responding appropriate to 0.04 mg/kg fentanyl at doses which were 3.0- and 1.6-fold higher, respectively, than in drug-saline discrimination. Naloxone antagonized the stimulus effects of 0.04 mg/kg fentanyl at 9.8-fold lower doses than in drug-saline discrimination. The dose-effect curves of fentanyl and naloxone in rats discriminating 0.04 mg/kg from 0.02 mg/kg fentanyl, were steeper than in rats discriminating 0.04 mg/kg fentanyl from saline. While cyclazocine, nalorphine and N-allylnormetazocine acted as mixed and partial agonists/antagonists in drug-saline discrimination, those compounds acted as pure and complete antagonists of 0.04 mg/kg fentanyl in dose-dose discrimination. The rank order of compounds in antagonizing the stimulus effects of 0.04 mg/kg fentanyl in dose-dose discrimination was naloxone 〉 N-allylnormetazocine 〉 cyclazocine 〉 nalorphine. It is suggested that a greater magnitude of opiate activity is required for producing generalization with the same 0.04 mg/kg dose of fentanyl in dose-dose as compared with drug-saline discrimination. Dose-dose discrimination may afford a more accurate method than drug-saline discrimination for assessing the equivalence of the discriminative stimulus properties of drugs. The data obtained in the present study are consistent with the hypothesis that the discriminative stimulus effects of the opiate compounds studied are mediated by a molecular mechanism involving only a single opiate receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181246
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  • 5
    Electronic Resource
    Electronic Resource
    Roles of amino acids, protein, and fiber in leaf-feeding resistance of corn to the fall armyworm (1990)
    Springer
    Journal of chemical ecology 16 (1990), S. 1977-1995 
    Details
    ISSN: 1573-1561
    Keywords: Fall armyworm ; Spodoptera frugiperda ; Lepidoptera ; Noctuidae ; corn ; Zea mays ; plant-insect interaction ; amino acids ; herbivory ; feeding resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The free amino acids have been shown by isolational work and choice bioassays to be more important than all other factors evaluated in defining leaf-feeding resistance of corn (Zea mays L.) to fall armyworm (FAW) [(Spodoptera frugiperda J.E. Smith)] larvae. 6-MBOA (6-methoxybenzoxazolinone) and maysin, toxins present in corn, were shown not to be significant factors for leaf-feeding resistance to first-instar FAW larvae because of their low concentrations in the whorl. Amino acid analysis showed that while the ratios of the essential amino acids in susceptible (S) and resistant (R) lines were similar, there were differences in the nonessential amino acids, particularly aspartic acid, which was higher in R lines. Also, the ratio of essential amino acids to nonessential amino acids was important, being too low in expressed whorl leaf juice (obtained from V8–V10 growth stage plants) to support larval growth, although juice was stimulatory in choice tests. The total protein content of whorls in S lines was about 15% higher than in R lines, but the significance of this difference is uncertain, because nutritional tests showed that larval growth increased with total protein only up to 12% protein. Sugars were only slightly stimulatory. Thus, the amino acids along with higher hemicellulose content of R lines, established by us earlier, appear to explain much of the basis of resistance in corn to larval leaf-feeding of the FAW.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020510
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of flavonoids inGossypium arboreum (L.) cottons as potential source of resistance to tobacco budworm (1992)
    Springer
    Journal of chemical ecology 18 (1992), S. 105-114 
    Details
    ISSN: 1573-1561
    Keywords: Cotton ; Gossypium arboreum ; tobacco budworm ; Heliothis virescens ; Lepidoptera ; Noctuidae ; resistance ; allelochemicals ; flavonoids ; gossypetin 8-0-rhamnoside ; gossypetin 8-0-glucoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Asiatic cottons [Gossypium arboreum (L.)] have been investigated as a source of resistance to the tobacco budworm [Heliothis virescens (Fab.)] because their diversely colored petals have been presumed to contain various allelochemicals. However, we found that larvae fedG. arboreum squares (buds) grew about equally compared with those fed squares from commercialG. hirsutum lines. The best source of resistance was found in severalG. hirsutum double-haploid (DH) lines. In our investigation of allelochemicals, G.arboreum lines were found to contain much less gossypol in leaves, squares (buds), and petals thanG. hirsutum L. lines. Flavonoids were significantly higher inG. arboreum lines only in petals. Of 22G. arboreum lines from which squares were gathered and fed to tobacco budworm (TBW) larvae in the laboratory, larval growth was not significantly decreased on any, but larval survival was decreased on six. When the square flavonoids were isolated and incorporated in laboratory diets for the TBW, moderate toxicity was observed. However, the estimated toxicities were not greater than those of the same flavonoid isolates fromG. hirsutum lines. The most prevalent flavonoids, all previously found in G.arboreum plant tissues, were gossypetin 8-0-glucoside and gossypetin 8-0-rhamnoside, neither of which were present inG. hirsutum tissue. Quercetin 3-0-glucoside, quercetin-3′-0-glucoside, and quercetin 7-0-glucoside were also present in significant amounts in both species. Gossypetin 8-0-rhamnoside and gossypetin 8-0-glucoside were the most toxic flavonoids tested (the ED50% was estimated to be 0.007 and 0.024) and therefore may prove to be contributing factors of resistance to TBW feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00993746
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  • 7
    Electronic Resource
    Electronic Resource
    2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one (N-O-Me-DIMBOA), a possible toxic factor in corn to the southwestern corn borer (1993)
    Springer
    Journal of chemical ecology 19 (1993), S. 531-542 
    Details
    ISSN: 1573-1561
    Keywords: Corn ; Zea mays (L.) ; southwestern bora borer ; Diatraea grandiosella ; Dyar ; Lepidoptera ; Pyralidae ; feeding resistance ; 2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one ; N-O-Me-DIMBOA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The southwestern corn borer (SWCB),Diatraea grandiosella Dyar, is a major pest of corn,Zea mays L., in the southern United States. The damage to corn is caused primarily by larval feeding on leaf, ear, and stem tissues. In this study, 2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one (N-O-Me-DIMBOA) was identified by MS and NMR as present in corn whorl surface waxes. This compound has evidently not been isolated previously, but its glucoside has been reported in corn, wheat, andCoix lachryma. It is present in the waxes in a higher concentration than DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) and 6-MBOA (6-methoxybenzoxazolinone). It was toxic to the SWCB in a stress diet, but it was less toxic to this insect than 6-MBOA when incorporated in the standard rearing diet. Nevertheless, it may have some role in the resistance of corn to the SWCB because the total surface wax content is higher in resistant lines than in susceptible lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00994323
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  • 8
    Electronic Resource
    Electronic Resource
    Differential haloperidol effect on two indices of fentanyl-saline discrimination (1977)
    Springer
    Psychopharmacology 53 (1977), S. 169-173 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Fentanyl ; Drug discrimination ; Narcotic cue ; Discrimination index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a discrete-trial, two-lever, foodreward discrimination learning paradigm, we trained rats (n=6) to discriminate 0.04 mg/kg fentanyl (s.c. t-30′) from saline. Stimulus generalization experiments with an adequate dose range (0.01–0.04 mg/kg) of fentanyl revealed that the ED50 value for drug lever selection is 0.02 mg/kg, irrespective of whether the animals were pretreated (s.c., t-60′) with either saline or 0.08 mg/kg haloperidol. With increasing doses of the haloperidol-fentanyl combination, the percentage of total responding on the selected lever progressively decreased, and reached the 50% level at the highest drug combination. It is concluded that this percentage is heavily contaminated by factors unrelated to the discrimination condition being studied; these factors seem to invalidate this percentage as a discrimination index under experimental conditions (e.g., behaviorally toxic doses of drugs) where they are likely to operate. The use of response selection as a discrimination index in drug discrimination research is further argued.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426488
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  • 9
    Electronic Resource
    Electronic Resource
    Theoretical and methodological considerations on drug discrimination learning (1976)
    Springer
    Psychopharmacology 46 (1976), S. 169-177 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Cue ; State dependent learning ; Amphetamine ; Desipramine ; Haloperidol ; Chlordiazepoxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method is described which allows the assessment of discriminative stimulus properties of drugs, and the ability of amphetamine (0.16 mg/kg, s.c), chlordiazepoxide (5 mg/kg, p.o.), desipramine (5 mg/kg, s.c), and haloperidol (0.02 mg/kg, s.c.) to produce a discriminative stimulus complex (DSC) is evidenced. The method is found to yield clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects. In addition, the experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421388
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  • 10
    Electronic Resource
    Electronic Resource
    Host selection byBlepharipa pratensis (Meigen), a tachinid parasite of the gypsy moth,Lymantria dispar L. (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 311-320 
    Details
    ISSN: 1573-1561
    Keywords: Gypsy moth ; Lymantria dispar ; Lepidoptera ; Lymantriidae ; Blepharipa pratensis ; Diptera ; Tachinidae ; host selection ; contact chemical ; parasite behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The host selection process ofBlepharipa pratensis (Meigen), a tachinid parasite of the gypsy moth,Lymantria dispar L., was investigated. Once in the host's habitat, and following contact with a recently damaged leaf edge (cut, torn, eaten), the fly orients perpendicular to the edge and moves back and forth with the front tarsi grasping the damaged edge. Oviposturing (oviposition intention) may occur. Leaf exudates appear to arrest the fly on the leaf and increase tarsal examination (searching). If an edge of a gypsy moth-eaten leaf is contacted, oviposition usually occurs. Significantly more eggs are laid when host-browsed foliage is encountered, compared to mechanically cut or damaged foliage, indicating response to a cue left by the host during feeding. The number of host-damaged leaf clusters in an area significantly enhances oviposition there; in field-cage tests, significantly more eggs (7911) were laid in simulated-crown areas with all clusters browsed, compared to the adjacent areas containing 1/2 browsed (4200 eggs) and undamaged clusters (2209 eggs). A host selection sequence is suggested and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987859
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