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  • Polymer and Materials Science  (2)
  • Chemical Engineering  (1)
  • antibody production rate  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A kinetic analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 38 (1991), S. 733-741 
    Details
    ISSN: 0006-3592
    Keywords: hybridoma metabolism ; suspension culture ; antibody production rate ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The steady-state metabolic parameters for a murine hybridoma cell line have been determined in continuous suspension culture over a wide range of dilution rates. Long-term adaption occurred over seven months in culture and resulted in lower glucose consumption rates, reduced lactate production, higher cell viability, and, consequently, growth rates more nearly matching the dilution rate. Antibody production rates decreased over the first two months and then remained stable for at least 75 days. The antibody production rate was not found to be growth associated. Steadystate amino acid uptake rates are presented for a wide range of growth rates.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260380707
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Advanced biochemical engineering. By H. R. Bungay and Georges Belfort, Eds., John Wiley and Sons, New York, 1987 (1987)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 2096-2097 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690331232
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of collagen crosslinking on the rate of resorption of implanted collagen tubing in rabbits (1977)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 11 (1977), S. 297-314 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Collagen tubes were tanned with glutaraldehyde for different periods of time. Some were oxidized with periodate and sterilized with either 60Co (1.5 Mrad) or propylene oxide. The tubes were coated with polyfilamentous polyester fabric, filled with x-ray contrast material, and implanted subcutaneously in rats and rabbits. Rate of resorption was ascertained by x-ray procedure of progressive leakage of contrast material.A close relation between tanning time of the collagen fabric-combined prostheses and rate of their resorption in subcutis was found in both rats and rabbits. In rabbits, however, the implants were resorbed at a significantly faster rate than in rats. No effect of oxidation of collagen on the resorption was observed. Collagen tubes tanned for shorter time periods and sterilized with propylene oxide were more resistant to degradation than those sterilized with irradiation. This difference was absent, however, with material tanned for longer times.The mechanism of resorption of implanted collagen tubes was studied by morphological methods. The role of inflammatory cells in resorption is documented. The paper indicates the advantages as well as limits of the x-ray method of studying the resorption rate of biodegradable materials.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820110213
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Heat precipitation of poly (γ-hydroxy-L-proline) (1978)
    New York : Wiley-Blackwell
    Biopolymers 17 (1978), S. 1381-1384 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1978.360170521
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    Paper (German National Licenses)
    Fulltext
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