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  • Chemical Engineering  (1)
  • chiral separations  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Optimizing experimental conditions for minimum production cost in preparative chromatography (1994)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 40 (1994), S. 594-605 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Optimum experimental conditions and column design parameters are calculated for most economical separation of binary mixtures by preparative liquid chromatography. The solvent consumption and capital costs are regarded as the two major cost contributions. Calculations were performed by using the numerical solution of the equilibrium-dispersive model of chromatography and a nonlinear simplex algorithm. Solvent consumption depends only on the column efficiency, the retention factor, and the loading factor. The production rate depends on the particle size, the column length, the mobile-phase flow velocity, the retention and the loading factors, and can be optimized with or without recovery yield constraints. A hybrid objective function was constructed to find the tradeoffs between the production rate and the solvent consumption.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690400404
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Optimizing the sample size and the retention parameters to achieve maximum production rates for enantiomers in chiral chromatography (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 40 (1992), S. 1210-1217 
    Details
    ISSN: 0006-3592
    Keywords: chiral separations ; optimization ; chromatography, preparative ; production rate ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The optimum experimental conditions (sample size and mobile phase composition) are calculated for maximum production rate of either one of two enantiomers contained in feeds of different compositions (1/1, 1/10, and 10/1). The products are obtained at 99% purity. The calculations use the equilibrium-dispersive model of chromatography and the equilibrium isotherms determined experimentally from the rear, diffuse boundary of overloaded elution profiles. The production rate measured experimentally under the optimum conditions calculated agree with 4% of the calculated values. There is an optimum value for the retention factor which is higher than predicted by a model assuming constant separation factor, because both separation factor and retention decrease with increasing organic solvent concentration in the mobile phase. © 1992 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260401011
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    Paper (German National Licenses)
    Fulltext
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