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  • 1
    Electronic Resource
    Electronic Resource
    New Non-cytotoxic Approaches to Ovarian Cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 65-68 
    Details
    ISSN: 1569-8041
    Keywords: drug resistance ; genetic therapy ; immunotherapy ; metalloproteinase inhibitors ; radioconjugates ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two recent examples of conventional cytotoxic drugs, taxoids and topo I inhibitors, are set to make a real impact in the treatment of ovarian cancer. However, further progress may depend on novel approaches, focusing on other targets. This review will concentrate on those approaches which have already led to the initiation of clinical trials: agents designed to circumvent cellular drug resistance, signal transduction inhibitors, new hormonal agents, matrix metalloproteinase inhibitors, immunotherapy, immunotoxins and radioconjugates, and intraperitoneal genetic therapy, including the use of replicating viruses. In some cases, early clinical data are encouraging, but ultimately combined treatment with conventional agents may make most impact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008315603401
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Advanced Epithelial Ovarian Cancer: 1998 Consensus Statements (1999)
    Springer
    Annals of oncology 10 (1999), S. 87-92 
    Details
    ISSN: 1569-8041
    Keywords: CA 125 ; consensus ; management ; ovarian cancer ; prognostic factors ; second-line treatment ; surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: During an international workshop held in September 1998, a group of specialists in the field of ovarian cancer reached consensus on a number of issues with implications for standard practice and for research of advanced epithelial ovarian cancer. Methods: Five groups of experts considered several issues which included: biologic factors, prognostic factors, surgery, initial chemotherapy, second-line treatment, the use of CA 125, investigational drugs, intra-peritoneal treatment and high-dose chemotherapy. The group attempted to arrive at answers to questions such as: Are there prognostic factors, which help to identify patients who will not do well with current therapy? What is the current best therapy for advanced ovarian carcinoma? What directions should research take in advanced ovarian cancer? These issues were discussed in a plenary meeting. Results: One of the major conclusions drawn by the consensus committee was that in previously untreated advanc ed ovarian cancer, cisplatin plus paclitaxel has been shown to be superior to previous standard therapy with cisplatin plus cyclophosphamide (level I evidence). However, for many patients, carboplatin plus paclitaxel is a reasonable alternative because of toxicity and convenience considerations. Most participants felt that the benefits in terms of toxicity for the paclitaxel-carboplatin are such that its widespread adoption at this stage is justified. Until mature survival data are available a minority of investigators would recommend continued use of cisplatin plus paclitaxel, specifically for those patients with advanced disease with the best prognostic characteristics. For future clinical research in this area, new end points for randomised clinical trials, together with a new Trials Network, are proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008323922057
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In-situ monitoring of the resin transfer molding impregnation and cure process (1991)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 31 (1991), S. 56-60 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Resin transfer molding (RTM) of advanced fiber architecture materials promises to be a cost effective process for obtaining composite parts with exceptional strength. However there are a larger number of material processing parameters that must be observed, known, and/or controlled during the resin transfer molding process. These include the viscosity both during impregnation and cure. In-situ sensors which can observe these processing properties within the RTM tool during the fabrication process are essential. This paper will discuss recent work on the use of frequency dependent electromagnetic sensing (FDMS) techniques to monitor these properties in the RTM tool. Our objective is to use these sensing techniques to address problems of RTM scaleup for large complex parts and to develop a closed loop, intelligent, sensor controlled RTM fabrication process.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760310110
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    Paper (German National Licenses)
    Fulltext
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