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Congenital diaphragmatic hernia: lung compliance after antenatal tracheal obstruction or surgical correction of the defect (1996)

Ford, W. D. A. ; Cool, J. C. ; Parsons, D. ; [et al.]

Springer

Pediatric surgery international 11 (1996), S. 524-527

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ISSN: 1437-9813

Keywords: Diaphragmatic hernia ; Compliance ; Plug Fetal surgery

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Fetal lambs with diaphragmatic herniae (CDH) created surgically at 73 days' gestation were subjected to three different forms of intrauterine correction: silastic patch correction of the diaphragmatic defect plus an abdominal patch at 101 days gestation; an intrathoracic “silo” at 101 days; and a tracheal “plug” obstruction at 101 or 129 days. At 143 days' gestation (term 145–149 days), the lambs were delivered by caesarean section and ventilated for 30 min before undergoing respiratory compliance measurements. These results were compared to those of normal lambs and animals with uncorrected herniae. The total respiratory system compliance values in those groups undergoing corrections were remarkably similar: those with any form of correction had a significant improvement (P 〈 0.05) compared to those with herniae and no correction (patch = 1.57 = ± 0.182 ml/cm H2O; silo = 1.53 ± 0.179; plug at 101 days = 1.66 ± 0.311; plug at 129 days = 2.00 ± 0,175; without correction = 0.62 ± 0.073). None, however, reached the values of those with normal lungs: 2.72 ± 0.223 (P 〈 0.05). This improvement in compliance in all corrected groups suggests that fetal tracheal obstruction is as effective as the two more invasive forms of open fetal surgery carried out in this study and, as this procedure lends itself to surgery through a small uterine incision or “minimally invasive” surgery, it may be the procedure of choice to reduce the incidence of preterm labour for those human fetuses undergoing antenatal correction of a CDH.bb

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00626057

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Low-frequency Raman scattering by anharmonic DNA modes with A⇌B character modeled with a classical double-well oscillator (1984)

Martin, A. J.

New York : Wiley-Blackwell

Biopolymers 23 (1984), S. 471-491

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ISSN: 0006-3525

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The optical modes of DNA that displace one strand against the other are modeled by the motion of an oscillator in an asymmetric quartic double-well potential whose minima represent the A- and B-conformations. Assuming that the variation of the polarizability during vibration derives mainly from the tilting of the base rings relative to the helix axis, the total polarizability tensor is shown to possess approximately ellipsoidal symmetry and to depend nonlinearly on the instantaneous displacement of the two strands. The Raman spectrum of a collection of randomly oriented molecules is calculated. It consists of one or more peaks with characteristic shape. The depolarization ratio is 3/4, independent of molecular conformation and frequency. The results are discussed in the light of existing experimental and theoretical information.

Additional Material: 8 Ill.