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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 1 (1979), S. 171-174 
    ISSN: 1590-3478
    Keywords: Creutzfeldt-Jakob Disease ; Sheep Brain ; Sheep Rearing ; Fondhandling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario È stata studiata la distribuzione geografica dei luoghi di origine di 8 pazienti con CJD correlandola alla distribuzione, all'interno delle diverse regioni dell'Italia Centrale, e in parte Meridionale, delle aree a prevalente economia da pascolo, soprattutto pastorizia ovina. Si è indagata una eventuale connessione tra abitudini alimentari che comprendono la manipolazione a scopo alimentare ed il susseguente consumo di tessuti del SNC di ovini e la insorgenza della CJD. Viene avanzata la ipotesi che attraverso soluzioni di continuo nel rivestimento dei tegumenti delle estremità superiori, piuttosto che per la via della ingestione, l'agente virale della malattia potrebbe penetrare nell'organismo, per cui questo elemento sarebbe da tenere presente nell'affrontare i problemi connessi con le modalità di trasmissione della CJD.
    Notes: Abstract The places of origin of 7 out of 8 patients with CJD coincide with the distribution of sheep-rearing in central and southern Italy, confirming the suggested link between this disease and eating and-or handling sheep CNS tissue. Since 6 of the 8 cases were women, it seems more likely that the virus responsible for CJD enters the body through a break in the skin of the hands and forearms in the process of foodhandling rather than via the Digestive tract. This aspect should be borne in mind when investigating the problems of CJD transmission.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1984), S. 433-437 
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 70 eV electron impact mass spectra of some 1,3,4-thiadiazolo[3,2-a]pyrimidin-7-one and isomeric-5-one derivatives are discussed with the aid of defocused metastable spectra and exact mass measurements. The compounds are shown to be very stable to electron impact and ring contraction reactions are in most cases the characterstic fragmentations. Most importantly, the 7-one derivatives fragment by a retro-Diels-Alder process which does not occur in the 5-one isomers. This provides a diagnostic tool for differentiation between the isomers and for the unequivocal assignment of the structure.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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