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The influence of l-(5-oxohexyl-)3.7-dimethylxanthine (BL 191) on the endocrine and exocrine pancreatic function in man during and following secretin and cholecystokinin-pancreozymin stimulation (1973)

Dollinger, H. C. ; Raptis, S. ; Grebe, B. ; [et al.]

Springer

Research in experimental medicine 161 (1973), S. 327-334

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ISSN: 1433-8580

Keywords: Methylxanthines ; Phosphodiesterase ; Cyclic AMP ; Intestinal hormones ; Endocrine pancreas ; Exocrine pancreatic function ; Adrenergic alpha-receptors

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The intravenous administration of secretin or cholecystokinin-pancreozymin alone led to a short rapid rise in radio-immunologically measurable insulin, and to a stimulation of the hydrokinetic as well as the ecbolic, exocrine pancreatic function. During the administration of 1-(5-oxohexyl-)-3.7-dimethylxanthine (BL 191) no significant change in the endocrine and exocrine pancreatic secretion was registered, compared to the secretin injection alone, whereas BL 191 was able to inhibit the insulin and enzyme secretion after the administration of cholecystokinin-pancreozymin. The influence neither of secretin nor cholecystokinin-pancreozymin on the endocrine as well as the exocrine pancreas seems to be mediated directly by cyclic 3′-5′ adenosine monophosphate (cAMP), and the decrease of endocrine and exocrine pancreatic secretion, induced by cholecystokinin-pancreozymin during administration of BL 191, is probably due to an inhibition of the alpha-receptor system. Additional experiments are required for further elucidation of these conclusions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01851457

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Cope-Umlagerungen Donor-substituierter 1,5-Hexadiene (1982)

Dollinger, Michael ; Henning, Wolfgang ; Kirmse, Wolfgang

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 115 (1982), S. 2309-2325

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ISSN: 0009-2940

Keywords: Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Cope Rearrangements of Donor Substituted 1,5-HexadienesAlkoxy, alkylthio, and dialkylamino groups in position 3 of 1,5-hexadiene and in position 2 of 3,3-dimethyl-1,5-hexadiene have rather small effects on the Cope rearrangement (maximum rate acceleration by a factor of 60; maximum ΔEa = 5.5 kcal/mol = 23 kJ/mol). The pattern of substituent effects is more consistent with a diradicaloid mechanism than with a concerted sigmatropic rearrangement.

Notes: Alkoxy-, Alkylthio- und Dialkylaminogruppen in 3-Position des 1,5-Hexadiens und in 2-Position des 3,3-Dimethyl-1,5-hexadiens haben relativ geringen Einfluß auf die Cope-Umlagerung (Erhöhung der Reaktionsgeschwindigkeit maximal um den Faktor 60, ΔEa maximal 5.5 kcal/mol = 23 kJ/mol). Die Substituenteneffekte sind mit einem diradikalischen Mechanismus besser vereinbar als mit einer konzertierten sigmatropen Umlagerung.

Additional Material: 3 Tab.