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  • 1
    Electronic Resource
    Electronic Resource
    Diabetic glomerulopathy in the uninephrectomized rat resists amelioration following islet transplantation (1982)
    Springer
    Diabetologia 23 (1982), S. 347-353 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; uninephrectomy ; islet transplantation ; glomerulus ; mesangium ; basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Uninephrectomy is known to accelerate the development of both functional and morphological changes seen with experimental diabetic nephropathy in the rat. The present experiments utilized electron and light microscopic morphometric techniques to assess glomerular basement membrane width and the volumes of the total mesangium and its cellular and matrix components of inbred Lewis rats made diabetic at 6 weeks of age and uninephrectomized 9 days later. Immunofluorescent microscopy was used to evaluate IgG and C3 in the mesangium. The reversibility of established diabetic glomerular lesions in uninephrectomized diabetic rats after 7 months of diabetes was studied by performing intraportal transplant of neonatal pancreatic tissue. Renal biopsies were taken 2 months later in transplanted and non-transplanted animals. Islet transplantation lowered plasma glucose to normal levels (29.6 to 7.3 mmol/l) and raised plasma insulin values (6.3 to 53 μU/l). Glomerular basement membrane width in transplanted rats (268 nm) still exceeded the same measure (226 nm) in nondiabetic uninephrectomized rats. In transplanted animals volumes of the mesangium (0.51 × 106 μm3) and of its cellular (0.27 × 106 μm3) and matrix (0.24 × 106 μm3) components remained higher than similar measures in control rats (0.32 × 106, 0.17 × 106 and 0.15 × 106 μm3, respectively). Mesangial IgG in treated animals approached normal, but mesangial C3 remained similar to levels in non-transplanted diabetic control animals. These observations in uninephrectomized-diabetic rats contrast with previous observations in intact diabetic rats in which mesangial volumes and localization of immunoglobulins and complement returned to normal levels following islet transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253743
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The interaction of shock waves in cylindrical structures (1987)
    New York, NY : Wiley-Blackwell
    Plant/Operations Progress 6 (1987), S. 52-56 
    Details
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An experimental investigation into the validity and use of the hydraulic jump analogy for studying the interaction of shock waves in air with cylindrical structures.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prsb.720060113
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    Paper (German National Licenses)
    Fulltext
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