ISSN:
0887-624X
Keywords:
biodegradability
;
poly(lactic acid)
;
lactic acid-depsipeptide copolymer
;
ring-opening copolymerization
;
functionalized side-group
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Since poly(lactic acid) is the biodegradable polyester having low immunogenicity and good biocompatibility, it is utilized as a medical material. However, poly(lactic acid) is a water-insoluble crystalline polymer having no reactive side-chain group. Thus, the use of poly(lactic acid) is limited. To modify the properties of poly(lactic acid) and to introduce the functionalized pendant groups to poly(lactic acid), we synthesized two kinds of lactic acid-depsipeptide copolymers with reactive pendant groups, namely poly[LA-(Glc-Lys)] and poly[LA-(Glc-Asp)]. This was done through ring-opening copolymerizations of L-lactide with the corresponding protected cyclodepsipeptides, cyclo[Glc-Lys(Z)] and cyclo[Glc-Asp(OBzl)], and subsequent deprotection of benzyloxycarbonyl and benzyl groups, respectively. By changing the mole fraction of the corresponding depsipeptide units, the solubility, thermal transition and degradation behavior of the modified poly(lactic acid) could be varied. © 1997 John Wiley & Sons, Inc.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
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