Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 17 (1989), S. 327-345 
    ISSN: 1573-8744
    Keywords: enterohepatic recirculation ; pharmacokinetics ; hepatic extraction ; area under the first moment curve ; model ; bile ; mean residence time ; mean absorption time ; formulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A physiologically realistic model of enterohepatic cycling (EHC) which includes separate liver and gallbladder compartments, discontinuous gallbladder emptying and first-order absorption from both an oral formulation and secreted bile (ka po and ka b, respectively) has been developed. The effect of EHC on area under the first-moment curve (AUMC) of drug concentration in plasma and on parameters derived from the AUMC was investigated. Unlike AUC, AUMC is dependent on the time and time-course of gallbladder emptying, increasing as the interval between gallbladder emptying increases. Consequently, mean residence time (MRT) is also a time-dependent parameter. Analytical solutions for MRTiv and MRTpo were derived. Mean absorption time (MAT = MRTpo — MRTivj is also time-dependent, contrary to findings previously published for a model of EHC with a continuous time lag. MAT is also dependent on k a po , k a b and the hepatic extraction ratio. The difference between MRT po s two formulations with unequal k a po values may deviate from the difference in the inverse of their absorption rate constants. Implications for design and interpretation of pharmacokinetic studies include (i) MAT values may be dominated by the time-course of recycling rather than the time-course of the initial absorption, depending on the extent of EHC and (ii) the unpredictable nature of the time of gallbladder emptying will contribute to intrasubject variability in derived parameters during crossover studies. Knowledge of the extent of EHC is invaluable in deciding whether modification of the in vitro release characteristics of an oral formulation will have any effect on the overall time-course of absorption in vivo. Techniques to monitor or control gallbladder emptying may be helpful for reducing variability in pharmaco-kinetic studies for compounds which are extensively cycled in bile.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 13 (1985), S. 589-608 
    ISSN: 1573-8744
    Keywords: enterohepatic recirculation ; pharmacokinetics ; hepatic extraction ; area under the curve ; model ; bile ; simulated concentration-time curves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A physiologically realistic model is used to provide insight into the design of sampling protocols for accurate determination of AUC(0– ∞) for drugs subject to enterohepatic cycling. Through simulation of plasma concentration- time curves for such drugs it is found that (1) more than one peak is predicted after oral and intravenous administration of a single dose of drug, (2) the relative magnitude of peaks is dependent on the hepatic extraction ratio for both oral and intravenous drug administration, (3) the percent of the AUC(0– ∞) in later time intervals is also a function of the hepatic extraction ratio, and (4) present methods for the design of sampling protocols may not provide accurate estimates of AUC(0– ∞) (especially for highly extracted drugs), because (a) peaks are only evident at later times after intravenous administration when plasma sampling is less frequent, (b) much of the area occurs at later times, and (c) the amount of drug in the sampling compartment after oral administration is much lower than that after intravenous administration of drug and could be incorrectly interpreted as low bioavailability if sampling is not carried out for a long period of time. The types of oral and intravenous profiles predicted for highly extracted drugs are exemplified by data for naltrexone in the monkey.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 336 (1994), S. 620-622 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 37 (1994), S. 2841-2855 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The new method presented here is capable of building finite element meshes and managing their adaptation simultaneously to the object load case and geometry before any calculations, i.e. an a priori mesh adaptation is conducted. The principle relies on an analogy between a finite element mesh and the equilibrium position of a network of branches. Each branch is adequately sized by setting force-length ratios, called force densities. Starting from these data, the nodal co-ordinates are obtained through the solution of a linear system which describes the equilibrium state of the net. This method seems very attractive since the only given data are: a connectivity table, the number of boundary and interior nodes and a geometrical description of the boundaries.It is also demonstrated how to obtain the equilibrium nodal positions when boundary nodes are allowed to slide and evolution laws of force densities cope with punctual forces and geometric singularities. A comparison of results is conducted between meshes issued by the new technique and those obtained with standard FE codes.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 38 (1995), S. 3121-3142 
    ISSN: 0029-5981
    Keywords: computer aided design ; non-uniform rational B-spline ; Bézier ; restricted patches ; multi-connected surfaces ; node re-positioning ; mesh control ; adaptation ; free-form surface mesh ; force density ; network of bars ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An adaptive process controlling the position of nodes on a surface mesh is presented. The control can depend on one (or more) criterion(ria) about element quality. The mesh is attached, through the concept of classification, to a geometric model issued by a computer aided design software. Thus, the surface domain is described by entities currently available in such systems, i.e. any free-form patches like Non-Uniform Rational B-Spline or Bézier patches can be used, even if they are restricted. Multi-connected surface domains can be treated using the same geometrical definition. The method described allows nodes to slide on a patch or jump from a patch onto another one. Such movements greatly improve the mesh quality with regard to a chosen criterion. Problems occurring with patch-by-patch meshing techniques when surfaces patches exhibit significant size differences are then overcome. The adaptation technique can be made independent of CAD data structures and meshing techniques, hence it constitutes the basis of a mesh management module.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...