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  • Chemistry  (3)
  • Extraneuronal catecholamine uptake  (1)
  • FABMS  (1)
  • Mass spectrometry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Analysis of the in vivo phosphorylation state of protein phosphatase inhibitor-2 from rabbit skeletal muscle by fast-atom bombardment mass spectrometry
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 929 (1987), S. 208-219 
    Details
    ISSN: 0167-4889
    Keywords: (Rabbit skeletal muscle) ; FABMS ; Inhibitor-2 ; Mass spectrometry ; Phosphorylation ; Phosphoserine residues ; Protein phosphatase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(87)90178-9
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetics of the uptake and metabolism of 3H-(±) isoprenaline in the rat submaxillary gland (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 305 (1978), S. 51-63 
    Details
    ISSN: 1432-1912
    Keywords: Isoprenaline ; Submaxillary gland ; Extraneuronal catecholamine uptake ; “O-methylating systems” ; Corticosteroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The uptake and O-methylation of 3H-(±)isoprenaline was studied in slices of the rat submaxillary gland. 2. The initial uptake of 3H-isoprenaline after inhibition of catechol-O-methyl transferase (COMT) was described by a single saturable process with relatively high K m (311 μM) and V max (101 nmoles·g−1·min−1). Both corticosterone and normetanephrine were competitive inhibitors of uptake. 3. When examined at substrate concentrations lower than the K m for uptake (and after block of COMT), 3H-isoprenaline distributed into two compartments in the tissue which approached equilibrium with half times of 2.4 and 15.8 min. The filling of both compartments was inhibited by corticosterone or phenoxybenzamine and also by high-K+ medium (in which 118 mM NaCl of the incubation medium had been replaced by KCl), but remained unaffected on substituting 118 mM NaCl with Tris-HCl. 4. In tissues in which COMT was not inhibited, the metabolism of 3H-isoprenaline to 3H-O-methylisoprenaline proceeded at a constant rate from the beginning of the incubation with the amine. When the substrate concentration was very low, little unchanged 3H-isoprenaline was found in the tissue. On the other hand, at high substrate concentrations the parent amine accumulated in the tissue, and at a time when 0-methylation had reached a steady state, the accumulation of 3H-isoprenaline was continuing. 5. The formation of 3H-O-methylisoprenaline was impaired by the presence of corticosterone, normetanephrine, phenoxybenzamine or 17-β-oestradiol with no indication of inhibition of COMT. While lowering the external Na+ concentration (on replacing 118 mM NaCl by 236 mM sucrose) did not affect the formation of 3H-O-methylisoprenaline, replacement of 118 mM NaCl by KCl reduced it. 6. The dependence of the steady-state rate of formation of 3H-O-methylisoprenaline on the substrate concentration in the incubation medium showed that two saturable components participated in the O-methylation of 3H-isoprenaline (low K m system: K m =7.2 μM and V max=1.2 nmoles·g−1·min−1; high-K m system: K m =339 μM and V max=4.6 nmoles·g−1·min−1). Corticosterone and normetanephrine competitively inhibited both the low-K m and the high-K m O-methylation. 7. The results indicate that the submaxillary gland of the rat resembles other tissues in having a low-K m (high-affinity) “O-methylating system” as well as a high-K m (low-affinity) extraneuronal uptake mechanism for catecholamines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497006
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  • 3
    Electronic Resource
    Electronic Resource
    The characterization of polystyrene oligomers by field-desorption mass spectrometry (1990)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 355-359 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Field-desorption mass spectrometry has been used to characterize polystyrene oligomers of molecular weight up to 15 000 Da. The technique shows good agreement with molecular weight data calculated using vapour-phase osmometry and gel-permeation chromatography but in addition provides much more detailed information in terms of oligomer distribution and the nature of end groups present in the oligomers.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290040913
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  • 4
    Electronic Resource
    Electronic Resource
    High-sensitivity measurement of metastable ion abundancesSee Ref. 1. (1969)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1969), S. 751-753 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Measurement of metastable ion abundances over a dynamic range of 105 is possible with a specially designed mass spectrometer.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210020709
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of constants in the intrinsic viscosity-molecular weight equation (1958)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 27 (1958), S. 433-440 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In the modified Staudinger equation, [η] = Km[Mv]α, the constants Km and α are usually found from measurements of [η] and Mv. As the latter cannot be determined directly, the method adopted in the past has been to prepare fractions, determine Mn or Mw by such absolute methods as osmometry and light scattering, and then to assume that the fractions are sufficiently monodisperse to justify writing Mv = Mn = Mw. An alternative approach has been suggested in this paper, making use of the fact that, for a distribution arising from random degradation, Mv = constant × Mn; it has been shown that the appropriate distribution results from the heterogeneous hydrolysis of cotton. The method has been applied to the case of cellulose triacetate in chloroform and the following results have been obtained: Km = 2.51 × 10-4; α = 1.02.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1958.1202711533
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