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  • 1
    Electronic Resource
    Electronic Resource
    Tumour regression in non-small-cell lung cancer following neoadjuvant therapy. Histological assessment (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 469-477 
    Details
    ISSN: 1432-1335
    Keywords: Non-small-cell lung cancer ; Neoadjuvant therapy ; Regression grading ; Therapy-induced tumour regression ; Spontaneous tumour regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the scope of a prospective multi-centre study after neoadjuvant combined chemotherapy (carboplatin, ifosfamide, etoposide, vindesine) and radiotherapy (45 Gy) 40 resection specimens of locally advanced non-small-cell lung cancer were analysed in order to establish reproducible pathological/anatomical results of tumour regression. Resection specimens of 28 squamous cell carcinomas and 12 adenocarcinomas were investigated using serial sections of the primary lesion. The mean age of the patients was 57 years. The results were compared to spontaneous regressive changes in a control group of 50 untreated non-small-cell lung cancers. Marked scarry fibrosis in the region of the former primary tumour, concentric foci of fresh tumour necroses and surrounding foam cell clusters with transition into vascular granulation tissue could be established as characteristic features of therapy-induced tumour regression, whereas untreated carcinomas revealed necroses with adjoining vital tumour tissue. Using a threestep regression system, 3 tumours could be classified as grade I (no or only slight tumour regression), 10 tumours as grade IIA (marked but incomplete tumour regression, more than 10% vital tumour tissue), 20 tumours as grade IIB (less than 10% vital tumour tissue) and 7 tumours as grade III (complete tumour regression without vital tumour tissue). After a median follow-up period of 32.3 months in patients with grade IIB or III tumour regression (“responders”) the median survival time of 27.9 months was found to be significantly longer than in patients with grade I or IIA tumour regression (“non-responders”) with a median survival period of 13.7 months (log-rank test,P=0.020). The resection specimens analysed, which were obtained 7 weeks (on average) after the end of radiochemotherapy, did not show specific changes due to preoperative therapy, but quite characteristic histological alterations in the former tumour area were registered, which had been induced by combined neoadjuvant radiation and chemotherapy. The grade of therapy-induced tumour regression could be shown to be a significant prognostic factor in non-small-cell lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01192200
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  • 2
    Electronic Resource
    Electronic Resource
    p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 238-245 
    Details
    ISSN: 1432-1335
    Keywords: Key words Non-small-cell lung cancer ; Neoadjuvant therapy ; p53 ; Single-strand conformation polymorphism (SSCP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a phase II study for optimizing therapeutic management of locally advanced non-small-cell lung cancer the prognostic and therapeutic relevance of the p53 status was investigated. Biopsy or mediastinoscopy samples, collected prior to neoadjuvant chemoradiotherapy and corresponding resection specimens, were analysed immunohistochemically (CM1 antiserum) for p53 accumulation and molecular biologically (polymerase chain reaction/single-strand conformation polymorphism) for p53 mutations. The results were correlated to the response to therapy (regression grade) and to the survival times. p53 accumulation was found in 41.7% (prior to neoadjuvant therapy) and in 40.0% (after surgery) of the tumours. p53 mutation was demonstrated in 45.4% (prior to neoadjuvant therapy) and in 46.4% (after surgery) of the investigated tumours. Neither before nor after therapy was any correlation to the survival times or to the response to therapy seen in the collective analysed. Thus, such investigations are not suitable for identifying patients with locally advanced non-small-cell lung cancer who might benefit, to different extents, from neoadjuvant therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050039
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  • 3
    Electronic Resource
    Electronic Resource
    Regressionsgrading neoadjuvant behandelter nichtkleinzelliger Lungenkarzinome (1997)
    Springer
    Der Pathologe 18 (1997), S. 131-140 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Nichtkleinzellige Lungenkarzinome ; Neoadjuvante Therapie ; Therapieinduzierte Tumorregression ; Spontanregression ; Regressionsgrading ; Key words Non-small cell lung cancer ; Neoadjuvant therapy ; Therapy-induced tumor regression ; Spontaneous tumor regression ; Grading of tumor regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the scope of a multi-center-study 35 resection specimens from patients with locally advanced non-small cell lung cancer after neoadjuvant chemotherapy and radiation were processed histologically and graded according to the following regression grading system: grade I: no or only slight, in general spontaneous tumor regression, grade II a: incomplete tumor regression with more than 10 % and grade II b less than 10 % vital tumor tissue as well as grade III: complete tumor regression. In 15 patients with grade II a to III tumor regression roughly concentric foci of various size with a sequence of central tumor necrosis, narrow foam cell rim, vascular granulation tissue and peripheral scar formation were demonstrated as characteristic feature of response to neoadjuvant therapy. In patients with grade II b to III tumor regression (“responders”) median survival time of 27.9 months was significantly longer than in patients with grade I to II a tumor regression (“non-responders”) with a median survival time of 12.7 months.
    Notes: Zusammenfassung Im Rahmen einer Multicenterstudie zur Therapieoptimierung lokal fortgeschrittener nichtkleinzelliger Lungenkarzinome wurden Resektionspräparate von 35 Patienten nach neoadjuvanter Chemo- und Radiotherapie histologisch aufgearbeitet und dem folgenden Regressionsgrading zugeordnet: Grad I: keine oder nur geringe, i. allg. spontane Tumorregression, Grad II a: unvollständige Tumorregression mit mehr als 10 % und Grad II b: weniger als 10 % vitalem Tumorgewebe sowie Grad III: komplette Tumorregression. Bei 15 Patienten der Regressionsgrade II a bis III konnten als charakteristischer Ausdruck eines Ansprechens auf die neoadjuvante Therapie verschieden große angedeutet kokardenförmige Herde mit zentraler Tumornekrose, meist schmalem Schaumzellsaum, gefäßreichem Granulationsgewebe und peripherer Vernarbung nachgewiesen werden. Bei den als „Responder“ zusammengefaßten Patienten der Regressionsgrade II b und III lag mit 27,9 Monaten eine signifikant längere mediane Überlebenszeit vor als bei den als „Nonresponder“ zusammengefaßten Patienten der Regressionsgrade I und II a mit 12,7 Monaten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050201
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  • 4
    Electronic Resource
    Electronic Resource
    Tumour regression in non-small-cell lung cancer following neoadjuvant therapy. Histological assessment (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 469-477 
    Details
    ISSN: 1432-1335
    Keywords: Key words Non-small-cell lung cancer ; Neoadjuvant therapy ; Regression grading ; Therapy-induced tumour regression ; Spontaneous tumour regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the scope of a prospective multi-centre study after neoadjuvant combined chemotherapy (carboplatin, ifosfamide, etoposide, vindesine) and radiotherapy (45 Gy) 40 resection specimens of locally advanced non-small-cell lung cancer were analysed in order to establish reproducible pathological/anatomical results of tumour regression. Resection specimens of 28 squamous cell carcinomas and 12 adenocarcinomas were investigated using serial sections of the primary lesion. The mean age of the patients was 57 years. The results were compared to spontaneous regressive changes in a control group of 50 untreated non-small-cell lung cancers. Marked scarry fibrosis in the region of the former primary tumour, concentric foci of fresh tumour necroses and surrounding foam cell clusters with transition into vascular granulation tissue could be established as characteristic features of therapy-induced tumour regression, whereas untreated carcinomas revealed necroses with adjoining vital tumour tissue. Using a three-step regression system, 3 tumours could be classified as grade I (no or only slight tumour regression), 10 tumours as grade IIA (marked but incomplete tumour regression, more than 10% vital tumour tissue), 20 tumours as grade IIB (less than 10% vital tumour tissue) and 7 tumours as grade III (complete tumour regression without vital tumour tissue). After a median follow-up period of 32.3 months in patients with grade IIB or III tumour regression (“responders”) the median survival time of 27.9 months was found to be significantly longer than in patients with grade I or IIA tumour regression (“non-responders”) with a median survival period of 13.7 months (log-rank test, P=0.020). The resection specimens analysed, which were obtained 7 weeks (on average) after the end of radiochemotherapy, did not show specific changes due to preoperative therapy, but quite characteristic histological alterations in the former tumour area were registered, which had been induced by combined neoadjuvant radiation and chemotherapy. The grade of therapy-induced tumour regression could be shown to be a significant prognostic factor in non-small-cell lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050090
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  • 5
    Electronic Resource
    Electronic Resource
    Bestimmung des in Wasser gelösten Sauerstoffes mit o-Tolidin (1950)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 22 (1950), S. 542-544 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Die zur Zeit bekannten mit o-Tolidin arbeitenden Bestimmungsmethoden für in Wasser gelösten Sauerstoff werden kritisch betrachtet. An Hand von Vergleichsbestimmungen nach Winkler wird die Genauigkeit überprüft und daraus die Brauchbarkeit für die Wasseranalyse abgeleitet.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330222305
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  • 6
    Electronic Resource
    Electronic Resource
    Auswahl von Fluorkunststoffen Diskussion zu “Veränderung von Stahloberflächen durch Reibung” (1972)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 3 (1972), S. 318-322 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19720030611
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  • 7
    Electronic Resource
    Electronic Resource
    Oberflächenbeschichtung durch thermisches Spritzen (1973)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 4 (1973), S. 76-81 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Thermal spraying. Thermal spraying in comparison with other coating techniques is characterized by a broad variability of base and spraying materials. After a brief description of actually used equipments some coating properties are summarized. Thermally sprayed special metal will become interesting in near future from commercial and technical point of view. With those metals homogeneous coatings can be produced without porosity.
    Notes: Das thermische Spritzen zeichnet sich gegenüber anderen Verfahren zur Oberflächenbeschichtung durch die Vielfältigkeit der verwendbaren Grund- und Spritzwerkstoffe aus. Neben einer Beschreibung gegenwärtig eingesetzter Geräte wird kurz auf den Schichtaufbau eingegangen. Wirtschaftlich und technisch von besonderem Interesse werden in naher Zukunft thermisch gespritzte Schichten aus Sondermetallen sein, die sich unter Schutzgas porenfrei und homogen erzeugen lassen.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19730040206
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  • 8
    Electronic Resource
    Electronic Resource
    Interdisziplinäre Entwicklung eines künstlichen Kniegelenks (Kniegelenks-Endoprothese) in Kunststoff-Metall-KombinationsbauweiseVortrag anläßlich des 4. Darmstädter Kunststoff-Kolloquiums vom 17. bis 19. Feb. 1975. (1975)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 6 (1975), S. 290-306 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Interdisciplinary development of an artificial knee joint endoprosthesis as a “combined plastic-metal-construction”.Endoprostheses for joints of the human locomotor apparatus under certain indications serve as permanent implants for eliminating painful changes of joints (e. g. arthrosis) as well as for restoration of essential joint functions (e. g. knee bending).The complexe correlation of biological-physiological factors and problems concerning materials and nature of load requires the adequate interdisciplinary co-operation of orthopaedic surgeons and engineers.On example of the prototype development of a total prosthesis for the knee joint the biomechanical conditions are sketched by means of the kinematics, statics, dynamics and tribology of normal natural joints (hip and knee) as a basis for the derivation of compensational functions.Already existing models are discussed, and the conception as well as the construction and production of the prototype of an artificial knee joint (“hinge joint-principle”) as a combined “plastic-metal-system” is described.
    Notes: Endoprothesen für Gelenke des menschlichen Bewegungsapparates dienen als Dauerimplante bei bestimmter Indikation zur Beseitigung schmerzhafter Gelenksveränderungen (z. B. Arthrosen) sowie zur Wiederherstellung wesentlicher Gelenkfunktionen (z. B. Kniebeugung).Das komplexe Zusammenwirken biologisch-physiologischer und stofflich-beanspruchungsmäßiger Einflußfaktoren macht die adäquate Zusammenarbeit von Ärzten und Ingenieuren erforderlich.Am Beispiel der Prototyp-Entwicklung einer Kniegelenks-Totalendoprothese werden die biomechanischen „Randbedingungen“ anhand Kinematik, Statik, Dynamik und Tribologie natürlicher Gelenke (Knie, Hüfte) als Basis für das Ableiten von Ersatzfunktionen skizziert. Bereits bestehende, beispielgebende Ersatzfunktionen werden diskutiert und die darauf begründete Konzeption und Gestaltung eines künstlichen Kniegelenks in Kunststoff-Metall-Kombinationsbauweise („KMK“) dargestellt, bei dem versucht wird, die Vorteile bisheriger Konstruktionen zu nutzen und Nachteile soweit möglich zu eliminieren.
    Additional Material: 28 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19750060903
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  • 9
    Electronic Resource
    Electronic Resource
    Berichte über Tagungen und Messen (1972)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 3 (1972), S. 98-103 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19720030212
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  • 10
    Electronic Resource
    Electronic Resource
    Gestaltung gewölbter Körper am Beispiel spritzgegossener Halbkugelschalen aus Thermoplasten (1986)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 17 (1986), S. 38-38 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19860170110
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