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Hepatocyte nuclear factor-1a gene and non-insulin-dependent diabetes mellitus in the Japanese population (1998)

Babaya, N. ; Ikegami, H. ; Kawaguchi, Y. ; [et al.]

Springer

Acta diabetologica 35 (1998), S. 150-153

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ISSN: 1432-5233

Keywords: Key words Non-insulin-dependent diabetes mellitus ; MODY ; Hepatocyte nuclear factor-1α ; Genetics ; Microsatellite polymorphism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Recently, hepatocyte nuclear factor-1α (HNF-1α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mellitus (type 2) in Japanese subjects by investigating allelic association with type 2 diabetes use of three markers. We also studied the frequency of the G191D mutation, the only mutation of TCF1 reported so far in late-onset type 2 diabetes. A total of 356 subjects were studied. There were no significant differences in allele frequency of the three markers between patients with type 2 diabetes and control subjects. A G191D mutation was not found in the subjects studied, giving a frequency of less than 0.4% in common type 2 diabetes. The lack of association of type 2 diabetes with three markers in and near TCF1 suggests that mutations in TCF1 derived from a limited number of founders are not a major cause of common type 2 diabetes even in the genetically homogeneous Japanese population. The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s005920050120

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Decrease in iron oxidizing activity of Thiobacillus ferrooxidans adsorbed on activated carbon (1990)

Kai, T. ; Takahashi, T. ; Shirakawa, Y. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 36 (1990), S. 1105-1109

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ISSN: 0006-3592

Keywords: Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: It was observed that about 90% of free-swimming Thiobacillus ferrooxidans in 9 K medium was adsorbed on added activated carbon when the concentration of the cultivated bacteria reached about 4 × 1013 cells m-3. The oxidation of ferrous iron and the leaching of copper ore were carried out in shake flasks and in aerated columns. The rates of oxidation and leaching increased when bacteria adsorbed on activated carbon were used. However, the evaluation of the reaction rates by eliminating the catalytic effect of activated carbon showed that the contribution to the reaction by the adsorbed microorganism was very small.

Additional Material: 8 Ill.