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  • 1
    ISSN: 1432-0584
    Keywords: HLA antigens ; Regulation in vivo ; Interferon ; Myeloproliferative syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen patients with myeloproliferative syndrome (14 with chronic myeloid leukemia, four with essential thrombocytosis) were investigated for modulation of HLA antigens on peripheral blood lymphocytes, monocytes, and hematopoietic precursors during IFNα therapy as a sign of potentially increased immune recognition of malignant cells. After 1 month of IFNα therapy, an increased number of monocytes and hematopoietic precursor cells, but not of lymphocytes, expressed HLADQ antigens. In addition, a strong induction of HLA class-I antigens was found on both hematopoietic progenitors and normal peripheral blood mononuclear cells. With daily injections of IFN in the first month of therapy stimulation continuously increased, suggested a major effect of IFNa on hematopoietic progenitors with sustained enhanced expression of HLA class-I antigens during differentiation of myelomonocytic cells. HLA class-I antigen expression was consistently augmented by IFNα in all patients, irrespective of their hematological response.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 585 (1990), S. 65-74 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Esters of Stibonic Acid. II. Preparation and Properties of Esters of Methanestibonic Acid; Structure of Di-μ-methoxy-bis[dibromo-methoxy-methyl-antimony(V)]Dimeric alkoxy-bridged compounds of the type [CH3SbX2(OR)(μ-OR)]2 (X = Cl, Br; R = CH3, C2H5) are prepared by oxidation of CH3Sb(OR)2 with Br2 or SO2Cl2 in CH2Cl2 below -60°C as light sensitive crystals. The structure of [CH3SbBr2(OCH3)(μ-OCH3)]2 was determined by X-Ray analysis. By reaction with sodium alkoxides in the corresponding alcohol at 0°C dimeric tetraalkoxymethylstiboranes are obtained. Exchange reactions of tetramethoxymethylstiborane with ethanol give the ethoxy derivative and with diols symmetric spirocyclic esters of methanestibonic acid.
    Notes: Dimere alkoxyverbrückte Verbindungen des Typs [CH3SbX2(OR)(μ-OR)]2 (X = Cl, Br; R = CH3, C2H5) können durch Oxidation von CH3Sb(OR)2 mit Br2 oder SO2Cl2 in CH2Cl2 unterhalb -60°C als lichtempfindliche kristalline Feststoffe erhalten werden. Die Struktur der Verbindung [CH3SbBr2(OCH3)(μ-OCH3)]2 konnte mittels Röntgenstrukturanalyse bestimmt werden. Umsetzungen mit Natriumalkoholaten in den entsprechenden Alkoholen bei 0°C führen zu dimeren Tetraalkoxymethylstiboranen. Austauschreaktionen von Tetramethoxymethylstiboran mit Ethanol ergeben das Ethoxyderivat und mit Diolen symmetrische spirocyclische Methanstibonsäureester.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 583 (1990), S. 102-112 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation of Pentahalogeno-methyl- and -phenylantimonates(V), Trihalogenomethyl-antimonates(III), and TetrahalogenophenylstiboranesComplex Salts R4E[MeSbCl5-nBrn] can be synthesized by reaction of MeSbCl2 with R4EX (X = Cl, Br: R4E = Ph4P, Ph4Sb) and SO2Cl2 or by oxidation of the new salts R4E[MeSbBr2X] with SO2Cl2 or Br2. The Phenylderivatives R4E[PhSbCl5-nBrn] are obtained by reaction of PhSbY2 (Y = Cl, Br) with R4EX (R4E = Ph4P: X = Cl, Br; R4E = Et4N: X = Br) and SO2Cl2 or Br2. Stabilization of PhSbBr2Y2 (Y = Cl, Br) with Et4NBr also yields Et4N[PhSbBr3Y2].
    Notes: Die Komplexsalze R4E[MeSbCl5-nBrn] können durch Reaktion von MeSbCl2 mit R4EX (X = Cl, Br: R4E = Ph4P, Ph4Sb) und SO2Cl2 sowie durch Oxidation der neu synthetisierten Salze R4E[MeSbBr2X] mit SO2Cl2 oder Br2 hergestellt werden. Die Phenylderivate R4E[PhSbCl5-nBrn] werden ebenfalls durch Umsetzung von PhSbY2 (Y = Cl, Br) mit Salzen R4EX (R4E = Ph4P: X = Cl, Br; R4E = Et4N: X = Br) und SO2Cl2 oder Br2 erhalten. Die erstmals synthetisierten Dibromodihalogenophenylstiborane PhSbBr2Y2 (Y = Cl, Br) können mit Et4NBr stabilisiert werden.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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