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  • 1
    Electronic Resource
    Electronic Resource
    Biochemische untersuchungen und psychologische studien an chronisch trichloräthylen-belasteten personen unter berücksichtigung expositionsfreier intervalle (1977)
    Springer
    International archives of occupational and environmental health 38 (1977), S. 149-162 
    Details
    ISSN: 1432-1246
    Keywords: Trichloroethylene ; Chronically exposed collective ; Psychological and biochemical examinations ; Trichloräthylen ; Chronisch belastetes Kollektiv ; Psychologische and biochemische Untersuchungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei arbeitsmedizinischen Studien sollte zwischen akuten, kurzfristigen and chronischen Belastungen unterschieden warden. In der vorliegenden Arbeit wurden an acht chronisch mit 260 mg/m3 (50 ppm) Trichloräthylen-Konzentration belasteten Personen psychologische and biochemische Untersuchungen durchgeführt. Mit den psychologischen Testverfahren wurde versucht zu klären, ob eine psychomentale Funktionsänderung im Sinne eines “Psychoorganischen Syndroms” beim untersuchten Personenkreis festzustellen ist. Die Ergebnisse der psychologischen Austestung ergaben keine Anhaltspunkte für eine Alteration des ZNS trotz nachgewiesener Lösungsmittelinkorporation. Die biochemischen Analysen sollten zum einen zeigen, in welcher Konzentration die verschiedenen Parameter im menschlichen Organismus auftreten. Zum anderen wurde geprüft, in welchem Umfang sich arbeitsfreie Intervalle auf den Trichloräthylen-, Trichloräthanol- und Trichloressigsäurespiegel in Blut und Urin auswirken. Die Gesamtmetabolitenausscheidungen, als auch die Blutspiegel zeigten bei dem untersuchten Kollektiv starke interindividuelle Schwankungen. Mit Ausnahme der Trichloressigsäure ergaben die Blut-parameter nach den expositionsfreien Intervallen einen Konzentrationsabfall. Dieses Verhalten wurde auch für die Trichloräthanol- und Trichloressigsäureexkretion im Urin gefunden. In den arbeitsfreien Zeiträumen kommt es nur langsam zu einer Elimination der Trichloräthylenabbauprodukte. Der für die Gesamtmetabolitenausscheidung derzeit diskutierte arbeits-medizinisch tolerierbare Grenzwert von 250 mg/g Kreatinin wurde bei unserem Kollektiv überschritten. Der Median lag am Ende einer Arbeitsschicht bei 330 bzw. 319 mg Trichlorathanol and Trichloressigsäure/g Kreatinin. Eine Erhöhung des arbeitsmedizinisch akzeptablen Grenzwertes wind diskutiert.
    Notes: Summary In studying occupational medicine one should differ between acute, short-term and chronic loads. In the authors' study psychological and biochemical examinations were made of eight chronically exposed persons with 260 mg/m3 (50 ppm) trichloroethylene concentration. The purpose of the psychological examinations was to clarify mental functioning alterations in the sense of “psychoorganicsyndrome” in the number of persons examined. In spite of proved incorporation of solvent the results of the psychological tests gave no hints of an alteration of the CNS. Biochemical analysis should show on the one hand, in which concentrations the different parameters appear in the human organism. On the other hand it should be determined to what extent non-exposure intervals have effect at the trichloroethylene, trichloroethanol and trichloroacetic acid levels in blood and urine. Excretion of total metabolites, as well as blood levels showed large-scale variations in the examined collective. With the exception of trichloroacetic acid the blood parameters showed a decrease of concentration after non-exposed intervals. This result could also be found for the excretion of trichloroacetic acid in urine. During the work-free periods the metabolites of trichloroethylene are eliminate only slowly. The threshold value of 250 mg trichloroethanol and trichloroacetic acid/g creatinine tolerated in occupational medicine today was surpassed by our collective. The median value was 330 and 319 mg trichloroethanol and trichloroacetic acid/g creatinine respectively at the end of a working shift. It is considered to increase the acceptable threshold value in occupational medicine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378353
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  • 2
    Electronic Resource
    Electronic Resource
    Lisinopril reduces postexercise albuminuria more effectively than atenolol in primary hypertension (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 267-271 
    Details
    ISSN: 1432-1041
    Keywords: Lisinopril ; Atenolol ; Hypertension ; urinary albumin excretion ; exercise ; ACE inhibition ; &gb-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Physical exercise causes transient albuminuria. The mechanisms of postexercise albuminuria are not fully clarified but stimulation of the reninangiotensin system (RAS) probably plays a major role through intrarenal haemodynamic changes causing an elevated filtration pressure. In a randomised, double-blind, crossover study we compared the effects on urinary albumin excretion (UAE) of lisinopril (L) and atenolol (A) therapy, i.e. we aimed to investigate whether inhibition of the RAS or inhibition of β1-adrenoceptor-mediated effects of the sympathetic nervous system differed with regard to changes in UAE. Sixteen patients with uncomplicated primary hypertension were studied. Four standardised bicycle ergometer exercise tests were performed, before and after each active treatment period. UAE 30 min postexercise, determined by radioimmunoassay, was significantly lowered by both treatments: -278 μg·min-1 (L) and-199 μg·min-1 (A). The reduction of postexercise UAE achieved by treatment with the angiotensin-converting enzyme (ACE) inhibitor (L) was significantly greater than that achieved by the β1-selective adrenoceptor blocker treatment. Blood pressure (BP) at rest and during exercise were equally reduced by both drugs. In conclusion, this study showed that antihypertensive treatment with an ACE inhibitor was more effective in reducing exercise-induced albuminuria than a β1-selective adrenoceptor-blocking agent with a similar degree of BP reduction in patients with uncomplicated primary hypertension. This suggests that the RAS plays a major role in postexercise albuminuria in hypertensive subjects. The clinical significance of this finding, however, remains to be clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226326
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  • 3
    Electronic Resource
    Electronic Resource
    Neues über radikalische Reaktionen mit Azoverbindungen und Peroxyden (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 597-597 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.196407613100
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  • 4
    Electronic Resource
    Electronic Resource
    Die Hydrostannierung ungesättigter Verbindungen (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 849-859 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Neue Arbeiten über die Addition von Organozinn-hydriden an Verbindungen mit C=C, C≡C, C=O, C=N, N=N, NCO, NCS und NO-Gruppen werden zusammengefaßt, weitere Ergebnisse mitgeteilt. Die Reaktionen verlaufen meistens radikalisch, seltener polar und können durch Katalysatoren sehr beschleunigt werden. Organozinn-hydride sind starke Radikalfänger und üben auf den Zerfall von Radikalbildnern weitgehende Einflüsse aus.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19640762003
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  • 5
    Electronic Resource
    Electronic Resource
    Die Chemie der α-Carbonyl-Azoverbindungen (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 78 (1966), S. 376-388 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Carbonyl-Azoverbindungen wie Azodicarbonsäurediester, Diacyl-Azoverbindungen und Aryl-azo-carbonsäureester sind recht reaktionsfreudige Verbindungen. Sie addieren sich z. B. an Amine, Aromaten, Olefine, CH-acide Substanzen, Grignard- und Diazo-Verbindungen, Aldehyde, Ketone und Ketene. Dabei sind u. a. Triazane, Hydrazone, Oxadiazolin-, Azomethin-imin- und Diazetidin-Derivate zugänglich. α,α'-Dicarbonyl-Azoverbindungen gehören zu den besten Dienophilen.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19660780705
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  • 6
    Electronic Resource
    Electronic Resource
    The Chemistry of α-Carbonyl Azo Compounds (1966)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 5 (1966), S. 372-384 
    Details
    ISSN: 0570-0833
    Keywords: α-Carbonyl azo compounds ; Azo compounds ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Carbonyl azo compounds such as diesters of azodicarboxylic acids, diacylazo compounds, and esters of arylazocarboxylic acids are highly reactive. They add e.g. to amines, aromatic compounds, olefins, CH acids, Grignard and diazo compounds, aldehydes, ketones, and ketenes. These reactions can be used for the preparation of triazanes, hydrazones, oxa-diazoline, azomethinimine, and diazetidine derivatives, etc. α,α′-Dicarbonyl azo compounds are among the strongest dienophiles known.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196603721
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  • 7
    Electronic Resource
    Electronic Resource
    Free-Radical Decomposition of Azo Compounds Induced by Organotin Hydrides (1967)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 6 (1967), S. 76-77 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196700762
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