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  • 1
    Electronic Resource
    Electronic Resource
    Lisinopril reduces postexercise albuminuria more effectively than atenolol in primary hypertension (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 267-271 
    Details
    ISSN: 1432-1041
    Keywords: Lisinopril ; Atenolol ; Hypertension ; urinary albumin excretion ; exercise ; ACE inhibition ; &gb-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Physical exercise causes transient albuminuria. The mechanisms of postexercise albuminuria are not fully clarified but stimulation of the reninangiotensin system (RAS) probably plays a major role through intrarenal haemodynamic changes causing an elevated filtration pressure. In a randomised, double-blind, crossover study we compared the effects on urinary albumin excretion (UAE) of lisinopril (L) and atenolol (A) therapy, i.e. we aimed to investigate whether inhibition of the RAS or inhibition of β1-adrenoceptor-mediated effects of the sympathetic nervous system differed with regard to changes in UAE. Sixteen patients with uncomplicated primary hypertension were studied. Four standardised bicycle ergometer exercise tests were performed, before and after each active treatment period. UAE 30 min postexercise, determined by radioimmunoassay, was significantly lowered by both treatments: -278 μg·min-1 (L) and-199 μg·min-1 (A). The reduction of postexercise UAE achieved by treatment with the angiotensin-converting enzyme (ACE) inhibitor (L) was significantly greater than that achieved by the β1-selective adrenoceptor blocker treatment. Blood pressure (BP) at rest and during exercise were equally reduced by both drugs. In conclusion, this study showed that antihypertensive treatment with an ACE inhibitor was more effective in reducing exercise-induced albuminuria than a β1-selective adrenoceptor-blocking agent with a similar degree of BP reduction in patients with uncomplicated primary hypertension. This suggests that the RAS plays a major role in postexercise albuminuria in hypertensive subjects. The clinical significance of this finding, however, remains to be clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226326
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  • 2
    Electronic Resource
    Electronic Resource
    Neues über radikalische Reaktionen mit Azoverbindungen und Peroxyden (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 597-597 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.196407613100
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  • 3
    Electronic Resource
    Electronic Resource
    Die Hydrostannierung ungesättigter Verbindungen (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 849-859 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Neue Arbeiten über die Addition von Organozinn-hydriden an Verbindungen mit C=C, C≡C, C=O, C=N, N=N, NCO, NCS und NO-Gruppen werden zusammengefaßt, weitere Ergebnisse mitgeteilt. Die Reaktionen verlaufen meistens radikalisch, seltener polar und können durch Katalysatoren sehr beschleunigt werden. Organozinn-hydride sind starke Radikalfänger und üben auf den Zerfall von Radikalbildnern weitgehende Einflüsse aus.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19640762003
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  • 4
    Electronic Resource
    Electronic Resource
    Die Chemie der α-Carbonyl-Azoverbindungen (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 78 (1966), S. 376-388 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Carbonyl-Azoverbindungen wie Azodicarbonsäurediester, Diacyl-Azoverbindungen und Aryl-azo-carbonsäureester sind recht reaktionsfreudige Verbindungen. Sie addieren sich z. B. an Amine, Aromaten, Olefine, CH-acide Substanzen, Grignard- und Diazo-Verbindungen, Aldehyde, Ketone und Ketene. Dabei sind u. a. Triazane, Hydrazone, Oxadiazolin-, Azomethin-imin- und Diazetidin-Derivate zugänglich. α,α'-Dicarbonyl-Azoverbindungen gehören zu den besten Dienophilen.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19660780705
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  • 5
    Electronic Resource
    Electronic Resource
    The Chemistry of α-Carbonyl Azo Compounds (1966)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 5 (1966), S. 372-384 
    Details
    ISSN: 0570-0833
    Keywords: α-Carbonyl azo compounds ; Azo compounds ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Carbonyl azo compounds such as diesters of azodicarboxylic acids, diacylazo compounds, and esters of arylazocarboxylic acids are highly reactive. They add e.g. to amines, aromatic compounds, olefins, CH acids, Grignard and diazo compounds, aldehydes, ketones, and ketenes. These reactions can be used for the preparation of triazanes, hydrazones, oxa-diazoline, azomethinimine, and diazetidine derivatives, etc. α,α′-Dicarbonyl azo compounds are among the strongest dienophiles known.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196603721
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  • 6
    Electronic Resource
    Electronic Resource
    Free-Radical Decomposition of Azo Compounds Induced by Organotin Hydrides (1967)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 6 (1967), S. 76-77 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196700762
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