Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Does long-term continuous administration of pentoxifylline affect platelet function in the critically ill patient? (1996)
    Springer
    Intensive care medicine 22 (1996), S. 644-650 
    Details
    ISSN: 1432-1238
    Keywords: Key words Pentoxifylline ; Critically ill ; Sepsis ; Trauma ; Inflammation ; Coagulation ; Platelet function ; Aggregometry ; Collagen ; Epinephrine ; Adenosine diphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The methylxanthine derivative pentoxifylline (PTX) is one of those promising substances which are under current investigation to modify or limit inflammatory response. Antiaggregation activity has also been described that may contribute to the beneficial effects of this substance. Long-term effects on platelet function have not been elucidated yet. Design: Prospective, randomized study. Setting: Clinical investigation on a surgical intensive care unit of a university hospital. Patients: 26 trauma patients and 26 patients suffering from sepsis secondary to major operations were consecutively studied. Interventions: The patients prospectively received either 1.5 mg/kg per h pentoxifylline continuously for 5 days (after a loading dose of 600 mg) (trauma-PTX, n=13; sepsis-PTX, n=13) or saline solution as placebo (trauma-control; n=13; sepsis-control, n=13). Measurements: On the day of admission (trauma patients) or day of the diagnosis of sepsis and at 12:00 p.m. during the next 5 days, platelet aggregation induced by adenosine diphosphate (ADP 2.0 μmol/l), collagen (4 μl/ml), and epinephrine (25 μmol/l) was determined by a turbidimetric method from arterial blood samples. Standard coagulation screen was also monitored. Main results: In untreated trauma and sepsis patients, maximum platelet aggregation induced by all three agonists decreased during the first few days after inclusion in the study [trauma: ADP–17.1±8.0 rel% (% change from baseline); sepsis: ADP –26.1±5.6 rel%]. In due course, maximum platelet aggregation recovered, reaching the baseline value or even exceeding it (trauma patients). In the PTX-treated patients, platelet aggregation was significantly less impaired (sepsis group: ADP –4.4±3.3 rel%) or even increased beyond baseline values in the first few days of the study (trauma group: ADP 16.1±8.0 rel%). Fibrinogen plasma levels were lower in the non-treated control groups (p〈0.05) than in the PTX groups. Conclusions: Continuous infusion of PTX for 5 days did not impair platelet function in critically ill patients. In both trauma and sepsis patients, the usual deterioration in platelet function was even attenuated, which may be due to the effects of PTX on cytokine release (e.g., reduction in tumor necrosis factor and interleukin-1), improvement in microcirculation, or additional fibrinolytic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709740
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Does long-term continous administration of pentoxifylline affect platelet function in the critically ill patient? (1996)
    Springer
    Intensive care medicine 22 (1996), S. 644-650 
    Details
    ISSN: 1432-1238
    Keywords: Pentoxifylline ; Critically ill ; Sepsis ; Trauma ; Inflammation ; Coagulation ; Platelet function ; Aggregometry ; Collagen ; Epinephrine ; Adenosine diphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The methylxanthine derivative pentoxifylline (PTX) is one of those promising substances which are under current investigation to modify or limit inflammatory response. Antiaggregation activity has also been described that may contribute to the beneficial effects of this substance. Long-term effects on platelet function have not been elucidated yet. Design Prospective, randomized study. Setting Clinical investigation on a surgical intensive care unit of a university hospital. Patients 26 trauma patients and 26 patients suffering from sepsis secondary to major operations were consecutively studied. Interventions The patients prospectively received either 1.5 mg/kg per h pentoxifylline continuously for 5 days (after a loading dose of 600 mg) (trauma-PTX,n=13; sepsis-PTX,n=13) or saline solution as placebo (trauma-control;n=13; sepsis-control,n=13). Measurements On the day of admission (trauma patients) or day of the diagnosis of sepsis and at 12:00 p.m. during the next 5 days, platelet aggregation induced by adenosine diphosphate (ADP 2.0 μmol/l), collagen (4 μl/ml), and epinephrine (25 μmol/l) was determined by a turbidimetric method from arterial blood samples. Standard coagulation screen was also monitored. Main results In untreated trauma and sepsis patients, maximum platelet aggregation induced by all three agonists decreased during the first few days after inclusion in the study [trauma: ADP −17.1±8.0 rel% (% change from baseline); sepsis: ADP −26.1±5.6 rel%]. In due course, maximum platelet aggregation recovered, reaching the baseline value or even exceeding it (trauma patients). In the PTX-treated patients, platelet aggregation was significantly less impaired (sepsis group: ADP −4.4±3.3 rel%) or even increased beyond baseline values in the first few days of the study (trauma group: ADP 16.1±8.0 rel%). Fibrinogen plasma levels were lower in the non-treated control groups (p〈0.05) than in the PTX groups. Conclusions Continuous infusion of PTX for 5 days did not impair platelet function in critically ill patients. In both trauma and sepsis patients, the usual deterioration in platelet function was even attenuated, which may be due to the effects of PTX on cytokine release (e.g., reduction in tumor necrosis factor and interleukin-1), improvement in microcirculation, or additional fibrinolytic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709740
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Über das intermediäre Auftreten von Benzocycloheptenin und Indin (1964)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 97 (1964), S. 1609-1618 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei oxydativer Zersetzung der Bis-hydrazone von 1.2-Benzo-cyclohepten-(1)-dion-(3.4) und Indandion-(1.2) in Gegenwart von Diphenylisobenzofuran bzw. Tetracyclon wurden die Addukte XI bzw. XIII und 1.2.3.4-Tetraphenyl-fluoren isoliert und in ihrer Konstitution aufgeklärt. Hiernach ist das intermediäre Auftreten von Benzocycloheptenin und Indin „sichtbar“ gemacht, deren Verhalten diskutiert wird. Versuche, 1-Chlor-2-brom-inden sowie 1-Chlor-2-brom-3.3-dimethyl-inden zu den zugehörigen Zwischenprodukten mit Kohlenstoffdreifachbindung zu enthalogenieren, führten nicht zum Ziel, da die primär entstehenden Metallhalogen-Derivate überraschend stabil waren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19640970613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Antiviral wirksame Koordinationsverbindungen des Palladiums mit Pyrid-2-yl-aminen (1983)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 325 (1983), S. 475-480 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Antiviral Active Complexes of Palladium Chloride with 2-Pyridine Amines2-Pyridine amines (L) form complexes with palladium chloride LPdCl2OH2 and L2PdCl2, respectively. The synthesis and analytical characterisation, ir-spectra, n.m.r.-spectra of these complexes with L = 2-pyridine amine, 4-methyl-2-pyridine amine and 6-methyl-2-pyridine amine and of π-allyl palladium chloride 4-methyl-2-pyridine amine are described.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19833250317
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Kupfer und Sauerstoff (1904)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 39 (1904), S. 1-23 
    Details
    ISSN: 0863-1778
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Die Erstarrung der Lösungen von Kupferoxydul in Kupfer erfolgt nach der Erstarrungsart 5, im besonderen nach Art 5a oder 5b nach BAKHUIS ROOZEBOOM. Die Löslichkeit des Kupfers gegenüber Kupferoxydul wird mit dem Übergang aus dem flüssigen in den festen Aggregatzustand praktisch gleich Null. Nach der Erstarrung hat also eine Trennung zwischen Kupfer und Kupferoxydul stattgefunden; es bestehen zwei feste Phasen, reines Kupfer und kupferoxydulreicher Körper (aller Voraussicht nach Kupferoxydnl selbst). Das reine Kupfer hat einen einheitlichen Erstarrungspunkt von 1103°C.1 Die eutektische Legierung mit 3.4 - 3.5 % Oxydul hat einen einheitlichen Erstarrungspunkt bei 1084 °C.1 Alle übrigen Legierungen haben eine sich über mehrere Wärmegrade erstreckende allmähliche Erstarrung, deren unterer Endpunkt bei 1084 °C. liegt. Der Beginn der Erstarrung wird durch das Kupferoxydul bis zu einem Gehalt von 3.4 % herabgedrückt, und bei weiter steigenden Gehalten wieder stark nach oben verschoben. Die Berechnung der Schmelzpunktserniedrigung nach der RAOULT, VAN'T HOFFschen Formel für verdünnte Lösung stimmt mit der Beobachtung überein.2. Abschreckung von zwischen Beginn und Ende der Erstarrung liegenden Warmegraden kann die Festhaltung des Kupferoxyduls im Kupfer im gelösten Zustande bei gewöhnlichen Wärmegraden nicht bewirken.3. Die zwei festen Phasen in den erstarrten Legierungen von Kupfer und Kupferoxydul verteilen sich auf 3 Gefügeelemente: a) oxydulfreies Kupfer in Form rundlicher Kristalliten. b) Kristalliten von Kupferoxydul, von grösserer Härte als Kupfer, von blauer Farbe im zurückgeworfenen und cochenilleroter Farbe im durchfallenden Licht. c) Eutektisches Gemenge von a und b in feinster Verteilung. Legierungen mit weniger als 3.4% Oxydul bestehen aus a + e, solche mit 3.4-3.5% dieses Körpers nur aus e, und solche mit noch höheren Gehalten aus b + e.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19040390102
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Kupfer und Phosphor (1907)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 52 (1907), S. 129-151 
    Details
    ISSN: 0863-1778
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Das Erstarrungsbild und das Gefüge der Phosphor-Kupferlegierungen wird ermittelt.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19070520114
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Kupfer, Zinn und Sauerstoff (1905)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 45 (1905), S. 52-68 
    Details
    ISSN: 0863-1778
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19050450107
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Immobilization of enzymes on langmuir-blodgett films via a membrane-bound receptor. possible. applications for amperometric biosensors (1991)
    Weinheim : Wiley-Blackwell
    Advanced Materials 3 (1991), S. 388-391 
    Details
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/adma.19910030711
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Potentialverlauf beim kathodischen Schutz von Schiffen mit Hilfe von Fremdstrom (1965)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 16 (1965), S. 549-553 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Potential distribution in ships cathodically protected by impressed currentThe potentiel distribution across the cathodic acreas is investigated with a view to optimizing the cathodic protection; for this purpose tow model arrangements are sued: individual arrangement or periodical array of circular anodes upon a square insulating shield in the cathode plane which was subdivided into squares. For the case of point-shaped anodes the mathematical treatment yields terms enabling the numerical evaluation by series techniques of the particular geometry factor as a function of the width of the insulating shield. the relations thus found can be used to determine the insulation shield width for a given cathode area (individual anode) or a given anode distance (periodical array). Another term represents the potential decay across the insulating shield and the cathode as a function of anode geometry and anode diameter (circular disks). Testing of the relation thus derived, using models in a flow channel, has resulted in satisfactory agreement - within the experimental error - between calculated and experimental results.
    Notes: An den Modellen  -  Einzel- bzw. periodische Anordnung kreisförmiger Anoden auf quadratischen Isolationsschirmen in der quadratischen unterteilten Kathodenebene  -  wird der Potentialverlauf über den Kathodenbezirken im Hinblick auf optimalen Kathodenschutz untersucht. Die mathematische Behandlung führt für den Fall punktförmiger Anoden auf Ausdrücke, aus denen der jeweilige Geometriefaktor als Funktion von Isolationsschirmbreite und Anodenabstand durch Reihenentwicklung zahlenmäßig ermittelt werden kann. Die Zusammenhänge können dazu benutzt werden, um bei gegebener Kathodenfläche (Einzelanode) oder gegebenen Anodenabstand (periodische Anordnung) die Isolationsschirmbreite zu berechnen. Ein weiterer Ausdruck stellt den Potentialabfall über Isolationsschirm und Kathode als Funktion der Anodengeometrie und des Anodendurchmessers (Kreisscheiben) dar. Die Überprüfung der abgeleiteten Beziehungen an Modellen im Strömungskanal ergibt innerhalb der Meßgenauigkeit befriedigende Übereinstimmung zwischen Rechnung und Experiment.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19650160702
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Untersuchung von IBBD-Aluminium-Schichten mittels elektrochemischer Rauschanalyse (1998)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 496-505 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Examination of IBDA-aluminum-layers by electrochemical noise analysisThe quality of extremely thin surface coatings for wear and corrosion protection is significantly influenced by pores and film defects (voids, micro cracks, coated impurities), which can occure in the processing stage. These sites are substantially responsible for a mechanical or chemical degradation of the coating at contact with respective surrounding conditions. To meet the requirements of protection the processing stage is optimized by minimizing pores and flaws. Therefore a suitable testing method is necessary to detect the dissolution of the substrate at voids in the earliest stage and to examine large series with acceptable time expenditure for a statistical accuracy. Investigations for the optimization of coating parameters were carried out by means of Electrochemical noise analysis (ENA) on IBAD-aluminum-layers (ion beam assisted deposition) at mild steel(Ck45).
    Notes: Die Qualität von extrem dünnen Oberflächenbeschichtungen für den Korrosions- und Verschleißschutz wird stark durch das Vorhandensein von Poren und Schichtdefekten (Hohlräume, Mikrorisse, Flimmer etc.)beeinflußt, die infolge des Herstellungsprozesses auftreten können. Diese Stellen sind maßgeblich verantwortlich für eine mechanische oder chemische Degradation der Beschichtung bei Kontakt mit der jeweiligen Umgebung. Um den erforderlichen Schutz durch die Beschichtung zu gewährleisten wird der Beschichtungsvorgang durch eine Minimierung von Poren und Fehlstellen optimiert. dazu ist eine Untersuchungsmethode erforderlich, die die Auflösung des Substrates an diesen Fehlstellen im frühesten Stadium anzeigt, um auch große Probenserien zur statistischen Absicherung mit vertretbarem Zeitaufwand zu untersuchen. An IBAD-Aluminium-schichten (ion beam assisted deposition) auf unlegiertem Stahl (Ck45) wurden mit Hilfe der elektrochemischen Rauschanalyse erfolgreich Untersuchungen zur Optimierung von Beschichtungsparametern duchgeführt.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19980290908
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...