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  • 1
    Electronic Resource
    Electronic Resource
    Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy (1994)
    Springer
    Virus genes 8 (1994), S. 99-105 
    Details
    ISSN: 1572-994X
    Keywords: JC virus ; progressive multifocal leukoencephalopathy ; brain ; sequence rearrangement ; regulatory region
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We established 99 JC virus (JCV) DNA clones directly from the brain of a single patient with progressive multifocal leukoencephalopathy (PML). Based upon restriction patterns, the cloned viral DNAs were classified into two major groups (NY-1A and -1B) containing 53 and 35 clones, respectively, and several minor groups containing one or a few clones. The regulatory sequences of representative clones were compared with the archetypal regulatory sequence, which has been detected in JCV DNAs cloned from the urine of healthy and nonimmunosuppressed individuals. The regulatory sequence of NY-1B had the two structural features common to most PML-type regulatory regions, duplication and deletion of specific segments in the archetypal sequence, while that of NY-1A contained a small deletion and an insertion of a 29-bp sequence originating from the early region of the JCV genome. A regulatory region similar to that of NY-1A has never been detected in JCV isolates obtained thus far.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703608
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Raman and Fourier transform infrared study of yeast alcohol dehydrogenase (1987)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 18 (1987), S. 119-122 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman spectra of yeast alcohol dehydrogenase in buffered, aqueous solutions and in D2O, and FTIR spectra of aqueous solutions and thin films have been collected and analyzed. No significant differences between the Raman spectra in the pH range 6.00-7.50 and between the infrared spectra of the solution and film have been observed. The tyrosine doublet strongly favors exposed hydroxyl groups and the Raman spectra indicate multiple conformations for the disulfide moieties. Analysis of Raman intensities favors significant α-helix and random coil contents. The secondary structure of yeast alcohol dehydrogenase based on Raman data is compared with the better characterized secondary structure of equine liver alcohol dehydrogenase.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250180210
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Raman spectra of porcine mitochondrial malate dehydrogenase (1988)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 267-269 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman spectra of porcine mitochondrial malate dehydrogenase have been collected and analysed. The existence of weak hydrogen bonds is indicated by the intensity ratio of the tyrosine doublet and a band is found which can be attributed to disulfide bonds. The observed frequencies in the amide I and III regions favor significant contributions from α-helix and random conformations. An analysis of the intensities using standard methods predicts a very low β-sheet content.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250190409
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    Paper (German National Licenses)
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