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Interactions of Primary Amphipathic Vector Peptides with Membranes. Conformational Consequences and Influence on Cellular Localization (1998)

Vidal, P. ; Chaloin, L. ; Heitz, A. ; [et al.]

Springer

The journal of membrane biology 162 (1998), S. 259-264

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ISSN: 1432-1424

Keywords: Key words: Amphipathic peptides — Conformations — Lipid-peptide interactions

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract. The conformations of two peptides produced by the combinations of a nuclear localization sequence and a sequence issued from the fusion protein gp41 of HIV 1 have been analyzed both in solution and in membranes or in membrane mimicking environments. Both are shown to be nonordered in water, α-helical when incorporated into SDS micelles where the helical domain concerns the hydrophobic part of the peptides. Interactions with lipids induce the formation of β-sheet and the lipid-peptide interactions are governed by the nature of the lipid polar headgroups. A monolayer study shows that replacement of the sequence separating the two sequences with an arginine favors the lipid-peptide interactions which may contribute to the understanding of the different, nuclear and membrane associated, cellular localizations of the peptides.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002329900363

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Solid-phase Synthesis and Cellular Localization of a C- and/or N-terminal Labelled Peptide (1996)

Vidal, P. ; Chaloin, L. ; Méry, J. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Peptide Science 2 (1996), S. 125-133

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ISSN: 1075-2617

Keywords: SPPS ; labelled peptides ; cellular localization ; amphipathic peptide ; Chemistry ; Biochemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: We report the solid-phase synthesis by the Fmoc strategy of a peptide containing a cysteamide group at its C-terminus. This peptide was subject to further modifications including the linkage of fluorophores, namely lucifer yellow and coumarin respectively, at the C- and/or N-terminals. After incubation with living cultured cells these two probes were localized and it is concluded that the post-synthesis modifications can strongly modify the localization of the peptide.

Additional Material: 5 Ill.