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  • 1
    Electronic Resource
    Electronic Resource
    MRI demonstration of subarachnoid neurocysticercosis simulating metastatic disease (1998)
    Springer
    Neuroradiology 40 (1998), S. 724-726 
    Details
    ISSN: 1432-1920
    Keywords: Key words Neurocysticercosis ; Subarachnoid space ; Spinal ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a patient with neurocysticercosis with spinal subarachnoid spread who presented with lower back pain and progressive numbness and weakness of the left leg. MRI of the spine simulated metastasis. MRI of the brain demonstrated a “bunch of grapes” appearance in the basal cisterns, characteristic of cysticercosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050672
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selective liver enzyme induction by carbamazepine and phenytoin in Chinese epileptics (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 411-415 
    Details
    ISSN: 1432-1041
    Keywords: Key words Anticonvulsants ; Paracetamol; liver enzyme induction ; cytochrome P450 induction ; Chinese ; 6ß-hydroxycortisol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Anticonvulsant drugs are known inducers of cytochrome P450 liver enzymes and it has been suggested that this induction increases susceptibility to paracetamol-induced hepatotoxicity. Methods: We measured the percentage urinary recovery of paracetamol and its metabolites after a dose of 20 mg kg−1, and the excretion of 6ß-hydroxycortisol as a ratio to urinary free cortisol(6ßOHF/F) in Chinese epileptic patients maintained on long term therapy with carbamazepine (n = 6) or phenytoin (n = 6). Results: Compared to the healthy controls (n = 20), patients on phenytoin had significantly lower recoveries of mercapturic acid, cysteine and sulphate metabolites, but a higher recovery of glucuronide metabolites of paracetamol. The recoveries of paracetamol metabolites in patients on carbamazepine were not different from controls. In contrast, the 6ßOHF/F was signi ficantly higher in patients on carbamazepine (3-fold) or phenytoin (2-fold) compared to controls. Healthy control Chinese subjects metabolised paracetamol in a similar way to that reported in Caucasians, indicating that the risk for hepatotoxicity would be the same. Our findings in a group of Chinese patients on phenytoin were also similar to those previously reported in Caucasians on this drug. The apparent differences in the pattern of isoenzyme induction between the groups on phenytoin and carbamazepine require verification in larger studies. The data do not suggest an increased risk of paracetamol-induced hepatotoxicity in Chinese patients on anticonvulsants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050132
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The assay of antibiotics in pharmaceutical preparations using reverse-phase HPLC (1979)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 2 (1979), S. 211-215 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Reverse phase separation of 9 antibiotics ; Down to 5 min analysis time, less than 4% repeat variation ; Precise analytical conditions given ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chromatographic methods are presented for the determination of chloramphenicol, erythromycin, tyrothricin, nystatin, penicillin, streptomycin, sulphanilamides and nitrofurans, in some pharmaceutical formulations. The methods have been applied in routine analysis and are in general capable of distinguishing the main antibiotic from decomposition products and likely congeners.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240020503
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  • 4
    Electronic Resource
    Electronic Resource
    Decomposition of Composite Explosives Containing Ammonium Nitrate by transient adiabatic gas compression (1995)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 20 (1995), S. 273-278 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The decomposition products of emulsion explosives and of other composite explosives containing ammonium nitrate, such as ANFO, were investigated. The compounds were thermolyzed at high temperature and pressure on the microsecond and millisecond time scales by adiabatic gas compression. It was found that the first step in emulsion decomposition is pyrolysis of the oil to form reactive intermediates like Hċ and CH3ċ. These reactive species are oxidized by the decomposition products of ammonium nitrate in a later sequence of reaction steps.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19950200509
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    Paper (German National Licenses)
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