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  • Chemistry  (7)
  • N-Nitroso-N-methylurea  (1)
  • N-Nitrosomorpholine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Kinetische Untersuchungen zur Bildung von N-Nitrosoverbindungen II. Entstehung von N-Nitroso-N-methylharnstoff in wäßriger Perchlorsäurelösung (1979)
    Springer
    Monatshefte für Chemie 110 (1979), S. 1331-1344 
    Details
    ISSN: 1434-4475
    Keywords: Kinetic study ; N-Methylurea ; Nitrosation ; N-Nitroso-N-methylurea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The kinetics of nitrosation of Methylurea (MU) in aqueous perchloric solution has been studied using two techniques: a dynamic spectrophotometric and a stopped-flow technique. The rate law obtained, whenpH was varied in the range 0.27–3.22, is $$---d[nitrite]/dt = f[MU][nitrite][H^ + ]/(1 + g/[H^ + ])$$ where [MU] and [nitrite] represent stoichiometric concentrations. At 288.0 K and μ=1.0M,f=(15.6±0.5)M −2s−1 andg=(1.06±0.08) 10−3 M. This rate law becomes independent of the acidity of the solution when this is increased ([ClO4H])〉1.00M). These results together with the activation of the nitrosation rate by the ionic strength and the negative value of the activation entropy shown that only the NO2H2 + or NO+ is the effective carrier for the nitrosation. Comparisons with the nitrosation of dimethylamine were also made leading to the conclusion that there is no simple explanation for the fact that the nitrosation via NO2H2 +/NO+ disappears when the nitrosable compound is of increased basicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00938290
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetic studies on the formation ofN-nitroso compounds VII. Nitrosation of morpholine in acetate buffer (1983)
    Springer
    Monatshefte für Chemie 114 (1983), S. 647-660 
    Details
    ISSN: 1434-4475
    Keywords: Acetate buffer ; Kinetics of nitrosation ; Morpholine ; N-Nitrosomorpholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde die Kinetik der Nitrosierung von Morpholin in Acetat-Puffer untersucht. Unter den gewählten Reaktionsbedingungen ist das effektive Agens N2O3, dessen Bildung von Acetat-Ionen im Einklang mit dem gezeigten Schema gefördert wird: Zwischen Nitrosylacetat und Amin wurde keine Reaktion beobachtet, vermutlich wegen der niederen Konzentration des ersteren. Der vorgeschlagene Mechanismus erklärt, daß keine Katalyse mittels Puffer unter Bedingungen zu beobachten ist, wo der geschwindigkeitsbestimmende Schritt die Reaktion von N2O3 mit dem Amin ist und daß der katalytische Effekt nur dann beobachtet wird, wenn die Bildung des Nitrosierungsagens geschwindigkeitsbestimmend ist. Gleichgewichts- und kinetische Konstanten, die für den Mechanismus von Bedeutung sind, wurden ermittelt.
    Notes: Abstract The kinetics of the nitrosation of morpholine in acetate buffer have been studied. It was found that in the experimental conditions used the effective nitrosating agent is dinitrogen trioxide, whose formation is promoted by the acetate ion in accordance with the scheme: No reaction between nitrosyl acetate and the a mine was observed, probably owing to the low concentration of the former. The proposed mechanism explains the experimental facts that no catalysis by the buffer is observed in conditions in which the rate controlling step is the reaction of N2O3 with the amine, and that the catalytic effect has only been observed when the formation of the nitrosating agent is also rate controlling. Values have been calculated for several equilibrium and kinetic constants involved in the mechanism proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01134178
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  • 3
    Electronic Resource
    Electronic Resource
    Nitrosation kinetics of phenolic components of foods and beverages (1997)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 29 (1997), S. 119-125 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the reactions between sodium nitrite and phenol or m-, o-, or p-cresol in potassium hydrogen phthalate buffers of pH 2.5-5.7 were determined by integration of the monitored absorbance of the C-nitroso reaction products. At pH 〉 3, the dominant reaction was C-nitrosation through a mechanism that appears to consist of a diffusion-controlled attack on the nitrosatable substrate by NO+/NO2H2+ ions followed by a slow proton transfer step; the latter step is supported by the observation of basic catalysis by the buffer which does not form alternative nitrosating agents as nitrosyl compounds. The catalytic coefficients of both anionic forms of the buffer have been determined. The observed order of substrate reactivities (o-cresol ≈ m-cresol 〉 phenol ≫ p-cresol) is explained by the hyperconjugative effect of the methyl group in o- and m-cresol, and by its blocking the para position in p-cresol. Analysis of a plot of ΔH# against ΔS# shows that the reaction with p-cresol differs from those with o- and m-cresol as regards the formation and decomposition of the transition state. The genotoxicity of nitrosatable phenols is compared with their reactivity with NO+/NO2H2+. © 1997 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Study of the effects of concentration and pH on the dissociation kinetics of Fe(II)-fulvic acid complexes (1998)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 30 (1998), S. 63-67 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The effects of reagent concentration and the pH in the kinetic behavior of the dissociation of Fe(II)-fulvic acid complexes were studied using a spectrophotometric technique. The results show that this behavior is not strongly affected by the concentration of fulvic acid, the concentration of the metal cation on the ratio of these concentrations and that variations in pH are more important in the dissociation process. A possible explanation based in the relative influence of proton concentration on the stability of the complexes is proposed. © 1998 John Wiley & Sons, Inc. Int J Chem Kinet: 30: 63-67,1998.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    The nitrosation of Amino AcidsThis article is dedicated to the memory of M. Elena Peña. (1994)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 26 (1994), S. 1167-1178 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: With a view to clarifying analogies and differences between the mechanisms involved in the nitrosation of amino acids and secondary amines, we studied the kinetics of the nitrosation of five imino acids (azetidine-2-carboxylic acid, pyrrolidine-2-carboxylic acid, piperidine-2-carboxylic acid, piperidine-3-carboxylic acid, and piperidine-4-carboxylic acid) and of the ethyl esters of three of them. Reaction kinetics were determined by the initial rate method, by spectrophotometric monitoring of the concentration of nitroso amino acid formed. The presence of the —COO- group in the amino acids opens a new mechanistic route for the nitrosation of the secondary amino group: a nitrosyl carboxylate formed initially acts as an internal nitrosating agent, resulting in intramolecular migration of —N = O from the carboxylate group to the secondary amino group. The observed order of the α-, β-, and γ-amino acids as regards the ease of N-nitrosation by this route is explained in terms of the relative energies of (a) the equatorial and axial orientations of the Cring—Ccarboxyl bond, and (b) the chair and boat forms of the piperidine ring. © 1994 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550261204
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  • 6
    Electronic Resource
    Electronic Resource
    Microemulsions as a medium in chemical kinetics, II. The I- + S2O8= and crystal Violet + OH- reactions in different surfactant/oil/water microemulsions (1992)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 24 (1992), S. 19-30 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A kinetic study of the reactions I- + S2O8= and CV+ + OH- (CV = 4, 4′, 4″-tris(dimethylamino)triphenylmethyl chloride or crystal violet) in different water in oil microemulsions is reported. The dependence of the rate constants on the nature of the surfactant as well as on the molar ratio R = [H2O]/[Surfactant] has been investigated. The results are interpreted on the basis of the electrostatic interactions between the reactants and the surfactant polar heads and considering the water properties inside the aqueous core of the droplets.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550240104
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  • 7
    Electronic Resource
    Electronic Resource
    The nitrosation of N-alkylureas: Evidence for a proton transfer mechanism (1996)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 28 (1996), S. 307-313 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the nitrosation of methyl, ethyl, propyl, butyl, and allyl urea were studied by conventional and stopped-flow spectrophotometry in the presence or absence of acetate or mono-, di-, or trichloroacetate anions. In the presence of a large excess of urea, the observed rate equation was $$v={{\rm [urea][nitrite][H^{+}]^2}\over{\rm K_a + [H^{+}]}} \left(\vartheta+\xi{{\rm K_R[carboxylic\ acid]}\over{\rm K_R+[H^{+}]}}\right)$$where Ka is the acidity constant of nitrous acid and KR that of the carboxylic acid. The ureas exhibited the reactivity order methylurea ≫ (ethylurea ≅ propylurea ≅ butylurea) ≫ allylurea. Experiments in D2O afforded values of kH2O/kD2O in general agreement with the values 4.1-5.5 predicted by a semiclassical transition state theory of kinetic isotope effects [i.e., kH2O/kD2O = exp(0.130hv⊼/kT)], where v⊼ is the frequency of R3N—H stretching (2700-2250 cm-1) in the protonated urea. This result, the observed catalysis by carboxylate ions and the value of the Bronsted parameter β(0.45) show the rate-controlling step of these reactions to be the transfer of a proton from the protonated N-alkyl-N-nitrosourea to the solvent or to the organic anion, if present. The observed order of substrate reactivities is explicable in terms of the capacity of the protonated N-alkyl-N-nitrosourea for forming a hydrogen bond with the water molecule to which the proton will be transferred, and the degree to which the formation of such bonds is hindered by the hydrophobic alkyl chain of the nitrosourea. © 1996 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.9
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  • 8
    Electronic Resource
    Electronic Resource
    Structural effects on the N-nitrosation of amino acids (1997)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 29 (1997), S. 495-504 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The relative importance of three different routes for the N- nitrosation of amino acids (nitrosation by N2O3, by NO+/NO2H2+ and by intramolecular migration of the nitroso group from the initially nitrosated carboxylate group) was investigated for methylaminobutyric acid, methylaminoisobutyric acid, azetidine-2-carboxylic acid, azetidine-3-carboxylic acid, indoline carboxylic acid, and phenylaminoacetic acid. Reaction kinetics were determined by the initial rate and Guggenheim methods, by spectrophotometric monitoring of the formation of nitroso amino acid. Kinetic parameters were calculated using a nonlinear optimization algorithm based on Marquardt's method. In the experimental rate equation the dominant term corresponds to nitrosation by dinitrogen trioxide, which experiments at various temperatures show to take place via an ordered transition state. Nitrosation by intramolecular migration is significant for substrates facilitating the formation of a transition state structure with a 5- or 6-membered ring. © 1997 John Wiley & Sons, Inc. Int J Chem Kinet 29: 495-504, 1997.
    Additional Material: 8 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    Photolysis of N-nitrosamines in neutral media (1993)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 25 (1993), S. 341-351 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The photolysis of N-nitrosamines in solutions of acetonitrile follows a first-order reaction with respect to the concentration of nitrosamine. Quantum yields are very low (≈ 0.1) and depend on the concentration of nitrosamine, with the observation of a linear correlation between the reciprocal of quantum yield and the reciprocal of nitrosamine concentration. For all the nitrosamines studied, the final product of the photolysis appears to be unique, alkylidenimine, which in the case of nitroso methyl benzyl amine undergoes a relatively rapid hydrolysis, giving rise to benzaldehyde, following second order kinetics. A provisional model consistent with the experimental results obtained in this work is proposed. © 1993 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550250503
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