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  • Chemistry  (1)
  • N-Propyl-N′-nitro-N-nitrosoguanidine  (1)
  • 1
    ISSN: 1432-1335
    Keywords: Gastric carcinoma ; Intestinal metaplasia ; N-Propyl-N′-nitro-N-nitrosoguanidine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 μg/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Rats were killed at intervals between week 1 and week 88. No marked atrophy or ulceration of the mucosa was found between week 1 and the end of the experiment. Focal intestinal metaplasia was found in week 19 and its incidence increased during the experiment. Adenocarcinoma in situ with extreme cellular atypia was found in mucosa with a normal appearance in week 67. An adenocarcinoma invading the submucosa was found in week 69, and one invading the serosa in week 88. All these pathological lesions were found on the anal side of the pyloric region. No pathologic changes were found in the fundic region. The sequential changes of the mucosa of the glandular stomach induced by this weak gastric carcinogen, PNNG, were very different from those induced by the potent gastric carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Gastric carcinoma induced by PNNG seems to be more similar to human gastric cancer than that induced by MNNG.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 50 (1993), S. 57-66 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The tensile strain rate effect in tensile strength and elongation at break for a series of filled dummy hydroxy-terminated polybutadiene (HTPB) propellant binders was studied. The data were obtained at various tensile strain rates from 10-4 to 10-1 s-1 on two types of specimens at room temperature. The “high velocity ductility” behaviour, which is qualitatively similar to those of unfilled elastomers, was revealed. This means that the breaking strain increases markedly at elevated strain rates. For “Bukkon-type” and rod-shaped specimens, test results are consistent with each other. The fact that the increased filled solids level leads to a decreased breaking elongation capability and an increased tensile strength was obviously found. © 1993 John Wiley & Sons, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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