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  • 1
    Electronic Resource
    Electronic Resource
    Studies on pyrazinyl-pyrazylidene tautomerism of pyrazine-acetonitrile derivatives (1984)
    Springer
    Monatshefte für Chemie 115 (1984), S. 179-185 
    Details
    ISSN: 1434-4475
    Keywords: CNDO/2-MO ; IR ; PMR ; UV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Gleichgewichte zwischen Pyrazinyl- und 2(1H)-Pyrazyliden-Formen von Pyrazinacetonitril-Derivaten wurden mittels IR-, PMR- und UV-Spektroskopie untersucht. Die Überschußladungen und Dipolmomente der zwei Tautomeren wurden nach dem CNDO/2-MO-Verfahren berechnet.
    Notes: Abstract The equilibria between the pyrazinyl and 2(1H)-pyrazylidene forms of pyrazineacetonitrile derivatives were studied by IR,1H-NMR and UV spectroscopy. The excess charges and dipole moments for the two tautomers were calculated by the CNDO/2-MO method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00798408
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative relationships between the structure of β-adrenolytic and antihistamine drugs and their retention on an α1-acid glycoprotein HPLC column (1994)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 8 (1994), S. 125-129 
    Details
    ISSN: 0269-3879
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Chromatographic retention parameters of a series of 7 β-adrenolytics and of 12 antihistamine drugs were determined employing an α1-acid glycoprotein (AGP) high-performance liquid chromatographic (HPLC) column. For the group of antihistamines capillary electrophoretic (CE) retention was additionally measured in the presence of either AGP or human serum albumin (HSA). Two series of solutes hydrophobicity parameters were obtained by reversed-phase HPLC on an immobilized artificial membrane (IAM) column. The solutes studied were subjected to molecular modelling and the structural descriptors obtained were applied in studies of quantitative structure-retention (protein binding) relationships (QSRR). It was found that retention on AGP correlates well with the literature on physiological protein binding data. This retention was demonstrated to depend on hydrophobicity: to a lesser extent in the case of β-adrenolytics and strongly in the case of antihistamines. Hydrophobicity, along with molecular width and electron excess charge on aliphatic nitrogen was demonstrated to describe retention of antihistamines on AGP. The AGP column is recommended as a convenient reactor for studies of drug-protein interactions. Preliminary CE data do not correlate with the HPLC data.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bmc.1130080306
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    Paper (German National Licenses)
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