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Substrate specificity and inhibitor profile of human recombinant p56lck from a baculovirus expression vector (1996)

Flotow, H. ; Purton, T. J. ; Whitaker, D. P. ; [et al.]

Springer

Inflammation research 45 (1996), S. 412-415

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ISSN: 1420-908X

Keywords: p56lck ; Peptide ; Substrate ; Inhibitors

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract p56lck, a member of the src family of nonreceptor protein receptor kinases, is required for normal signal transduction through the T cell receptor. Inappropriate T cell activation and proliferation has been identified as an early event in auto-immune disease —agents which control T cell activation through modulation of p56lck kinase activity could therefore be potential therapeutic agents for a range of pathological conditions. To identify p56lck inhibitors, we have established an assay system suitable for the high throughput screening of compound libraries. The assay uses enzyme purified from baculovirus infected SF9 cells, and a novel peptidic substrate identified by L. Cantley from a degenerate combinatorial peptide library. We have used this assay system to screen a number of different compounds as potential inhibitors of p56lck. In addition, peptides based on the substrate sequence were also tested to identify a sequence that could be used in the rational design of peptide inhibitors of p56lck.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02252937

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Axial dispersion and heat transfer in liquid-liquid spray towers (1967)

Mixon, F. O. ; Whitaker, D. R. ; Orcutt, J. C.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 13 (1967), S. 21-28

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: A radioptracer technique was utilized to measure axial dispersion in both phases in spray towers operated at and near flooding. A new method that exhibits certain advantages over methods employed in the past is presented for reducing such data. It is demonstrated that axial dispersion in flooded and near-flooded spray towers is sufficiently severe to control completely their performance as heat exchangers.

Additional Material: 5 Ill.