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  • Chemistry  (2)
  • antiestrogens  (1)
  • estrogens  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of tamoxifen on hepatic regeneration in male rats (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 27-32 
    Details
    ISSN: 1573-2568
    Keywords: hepatic regeneration ; estrogens ; tamoxifen ; antiestrogens ; hormone receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A number of metabolic changes within the liver occur concurrent with hepatic regeneration. These processes suggest that the administration of an antiestrogen might alter the rate of hepatic regeneration. To examine this question, male Wistar rats were treated with tamoxifen (0.1 mg/rat/day or 1.0 mg/rat/day) or vehicle for three days prior to and after partial hepatectomy, and the anatomic and biochemical process of hepatic regeneration was assessed. Tamoxifen administration caused a dose-dependent decrease in the hepatic cytosolic estrogen receptor activity and, conversely, a dose-dependent increase in cytosolic androgen receptor activity. Despite these changes in baseline hepatic sex steroid receptor status, all receptor activities were comparable between the three groups within 24 hr of partial hepatectomy. Moreover, no differences in any of the the parameters assessing hepatic regeneration following partial hepatectomy were evident: liver-body ratio, ornithine decarboxylase activity, and thymidine kinase activity. This lack of effect of tamoxifen treatment on hepatic regeneration suggests either that estrogens do not play a role in the modulation of liver growth after partial hepatectomy or that, once initiated, the regenerative process per sedetermines a series of events that regulate hepatocellular sex hormone receptor status independent of extrahepatic stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536150
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bethe-Bloch stopping power parameters for polystyrene, kapton, and mylar (1997)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 65 (1997), S. 997-1003 
    Details
    ISSN: 0020-7608
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Values of several parameters appearing in the modified Bethe-Bloch theory must be known if one is to calculate the stopping power for a given projectile-target combination within the energy interval of applicability of the theory. In the course of the past several years, the author has established values for kapton and mylar target materials through fits of experimental data with the modified Bethe-Bloch theory. During the past year, several sets of measurements of polystyrene stopping powers for light projectiles have been studied so as to extract values of Bethe-Bloch parameters also for this target material. Results of these studies, including uncertainties in the parameter values that reflect the number and accuracy of the measurements analyzed, are summarized in this presentation.   © 1997 John Wiley & Sons, Inc. Int J Quant Chem 65: 997-1003, 1997
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    Bethe-Bloch stopping-power parameters for GaAs and ZnSe (1998)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 70 (1998), S. 919-924 
    Details
    ISSN: 0020-7608
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: If one is to calculate the stopping power for a specified projectile-target combination within the energy interval of applicability of modified Bethe-Bloch theory, values of several parameters appearing in the formulation must be ascertained. In the past, the author has established such values for numerous target materials through fits of stopping-power measurements with modified Bethe-Bloch theory. However, the semiconductor materials ZnSe and GaAs have not yet been thus characterized. A set of very recent measurements of the stopping powers of each compound for low-energy protons and alpha particles, reported by members of the Helsinki group, has been analyzed in order to remedy this dearth of parameter values. Moreover, some corresponding measurements for 7Li ions traversing ZnSe have been analyzed for the purpose of obtaining the value of a single effective charge parameter. Results of these studies are reasonably consistent with expectations, and values are recommended for the mean excitation energy and the Barkas-effect parameter for each compound.   © 1998 John Wiley & Sons, Inc. Int J Quant Chem 70: 919-924, 1998
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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