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  • cerebrospinal fluid levels  (4)
  • Chemistry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 497-505 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease ; transition metals ; iron ; copper ; manganese ; zinc ; cerebrospinal fluid levels ; serum levels.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 37 patients with Parkinson's disease (PD) and 37 matched controls. The CSF levels of zinc were significantly decreased in PD patients as compared with controls (p 〈 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between PD-patient and control groups. There was no influence of antiparkinsonian therapy on CSF levels of none of these transition metals. These values were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group, with the exception of CSF copper levels with the duration of the disease (r = 0.38, p 〈 0.05). These results suggest that low CSF zinc concentrations might be related with the risk for PD, although they could be related with oxidative stress processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050073
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 479-488 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Alzheimer's disease ; transition metals ; iron ; copper ; manganese ; zinc ; cerebrospinal fluid levels ; serum levels.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 26 patients patients with Alzheimer's disease (AD) without major clinical signs of undernutrition, and 28 matched controls. CSF zinc levels were significantly decreased in AD patients as compared with controls (p 〈 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between AD-patient and control groups. These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. Because serum zinc levels were normal, the possibility that low CSF zinc levels were due to a deficiency of dietary intake seems unlikely. However, it is possible that they might be related to the interaction of beta-amyloid and/or amyloid precursor protein with zinc, that could result in a depletion of zinc levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050071
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid levels of selenium in patients with Alzheimer's disease (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 309-315 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Alzheimer's disease ; selenium ; cerebrospinal fluid levels ; serum levels.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We compared CSF and serum selenium levels, measured by atomic absorption spectrophotometry, in 27 patients with Alzheimer's disease (AD) (13 females, 14 males, mean ± SD age 73.6 ± 7.4 years) without major clinical signs of undernutrition, and 34 matched controls (18 females, 16 males, mean ± SD age 70.7 ± 7.8 years). CSF and serum selenium levels did not differ significantly between AD-patient (11.4 ± 7.8 ng/ml and 28.5 ± 13.0 ng/ml, respectively) and control groups (13.3 ± 7.0 ng/ml and 22.5 ± 17.5 ng/ml). These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. These results suggest that CSF selenium concentrations are apparently unrelated with the reported oxidative stress processes in patients with AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050160
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid selenium and chromium levels in patients with Parkinson's disease (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 1245-1251 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease ; selenium ; chromium ; cerebrospinal fluid levels ; serum levels.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We compared CSF and serum levels of selenium and chromium, measured by atomic absorption spectrophotometry, in 28 patients with Parkinson's disease (PD) and 43 matched controls. The CSF and serum levels of these trace metals did not differ significantly between PD patients and controls. CSF selenium and chromium levels were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. Although antiparkinsonian therapy did not influence significantly the CSF levels of selenium, PD patients not treated with levodopa had significantly higher CSF selenium levels than controls (p 〈 0.01). It is possible that increased CSF selenium levels could indicate an attempt of protection against oxidative stress. The normality of CSF and serum chromium levels suggest that these values are not related with the risk for PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050127
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Study of solvent effects by means of averaged solvent electrostatic potentials obtained from molecular dynamics data (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 18 (1997), S. 313-322 
    Details
    ISSN: 0192-8651
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: We present the theory and implementation of a new approach for studying solvent effects. The electronic structure of the solute, calculated at the ab initio level, is obtained in the presence of the surrounding medium. We employ a mean field theory in which the solvent response is described by means of point charges chosen in such a way that they reproduce the average value of the solvent electrostatic potential calculated from molecular dynamics data. In this way, the complete solvent potential can be introduced into the solute Hamiltonian without making use of a one-center multiple expansion of the solute-solvent potential. In the proposed method, only one quantum calculation has to be performed and a great number of configurations can easily be included making the calculation statistically significant. We show that, despite the large fluctuations in the solute charge distribution induced by the solvent, the proposed mean field theory adequately reproduces the energetics and properties of formamide and water molecules in aqueous solution. © 1997 by John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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