Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-0428
    Keywords: Keywords Glomerulosclerosis ; matrix metalloproteinase ; tissue inhibitor of metalloproteinases ; obese Zucker rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The obese Zucker rat represents a model of obesity combined with insulin resistance and hyperlipidaemia, which over a period of several months develops spontaneous glomerulosclerosis. The present study addressed the question as to whether glomerular sclerosis was associated with alterations in the degradation of matrix components. In the early phase (up to 6 months) glomeruli from obese rats displayed increased total collagen content (+ 64 %) and decreased gelatinolytic activity (− 34 %) as compared to lean control animals. This decline in glomerular gelatinolytic activity was due to a reduction in gelatinase B [matrix metalloproteinase (MMP)-9]. Glomerular MMP-9 mRNA was reduced 4.6 ± 0.6-fold (n = 3; p 〈 0.05), MMP-9 protein was not detectable by Western blotting and MMP-9 activity was considerably suppressed in gelatin zymograms. MMP-2, in terms of mRNA expression and activity, was unchanged. Tissue inhibitor of metalloproteinases (TIMP)-1 mRNA expression, TIMP-1 protein (immunohistochemistry) and TIMP-1 activity (reverse zymography) were enhanced in glomeruli from obese rats, while TIMP-2 mRNA remained unchanged. Moreover, mRNA for the α1 IV collagen chain was 2.1 ± 0.8-fold higher in glomeruli isolated from obese animals (n = 3; p 〈 0.05). These findings indicate that matrix expansion in glomeruli from obese Zucker rats is due to both enhanced synthesis of matrix components as well as reduced degradation by matrix metalloproteinases. Apparently the latter effect is based on a reduction in MMP-9 and up-regulation of its inhibitor TIMP-1. [Diabetologia (1997) 40: 1035–1043]
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Computational optimization and applications 15 (2000), S. 45-67 
    ISSN: 1573-2894
    Keywords: Successive Quadratic Programming ; reduced Hessian methods ; constrained optimization ; quasi-Newton method ; large-scale optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The reduced Hessian SQP algorithm presented in Biegler et al. [SIAM J. Optimization, Vol. 5, no. 2, pp. 314–347, 1995.] is developed in this paper into a practical method for large-scale optimization. The novelty of the algorithm lies in the incorporation of a correction vector that approximates the cross term ZTWYpY. This improves the stability and robustness of the algorithm without increasing its computational cost. The paper studies how to implement the algorithm efficiently, and presents a set of tests illustrating its numerical performance. An analytic example, showing the benefits of the correction term, is also presented.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 43 (1997), S. 986-996 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Efficient algorithms were developed for estimating model parameters from measured data, even in the presence of gross errors. In addition to point estimates of parameters, however, assessments of uncertainty are needed. Linear approximations provide standard errors, but they can be misleading when applied to models that are substantially nonlinear. To overcome this difficulty, profiling methods were developed for the case in which the regressor variables are error free. These methods provide accurate nonlinear confidence regions, but become expensive for a large number of parameters. These profiling methods are modified to error-in-variable-measurement models with many incidental parameters. Laplace's method is used to integrate out the incidental parameters associated with the measurement errors, and then profiling methods are applied to obtain approximate confidence contours for the parameters. This approach is computationally efficient, requires few function evaluations, and can be applied to large-scale problems. It is useful when certain measurement errors (such as input variables) are relatively small, but not so small that they can be ignored.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 2841-2856 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Gross-error detection plays a vital role in parameter estimation and data reconciliation for dynamic and steady-state systems. Data errors due to miscalibrated or faulty sensors or just random events nonrepresentative of the underlying statistical distribution can induce heavy biases in parameter estimates and reconciled data. Robust estimators and exploratory statistical methods for the detection of gross errors as the data reconciliation is performed are discussed. These methods have the property insensitive to departures from ideal statistical distributions and to the presence of outliers. Once the regression is done, the outliers can be detected readily by using exploratory statistical techniques. Optimization algorithm and reconciled data offer the ability to classify variables according to their observability and redundancy properties. Here an observable variable is an unmeasured quantity that can be estimated from the measured variables through the physical model, while a nonredundant variable is a measured variable that cannot be estimated other than through its measurement. Variable classification can be used to help design instrumentation schemes. An efficient method for this classification of dynamic systems is developed. Variable classification and gross-error detection have important connections, and gross-error detection on nonredundant variables has to be performed with caution.
    Additional Material: 26 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 40 (1994), S. 1138-1155 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Effects of hard constraints in the stability of model-perdictive control (MPC) are reviewed. Assuming a fixed active set, the optimal solution can be expressed in a general state-feedback closed form, which corresponds to a piecewise linear controller for the linear model case. Changes in the original unconstrained solution by the active constraints and other effects related to the loss of degrees of freedom are depicted in this analysis. In addition to modifications in the unconstrained feedback gain, we show that the presence of active output constraints can introduce extra feedback terms in the predictive controller. This can lead to instability of the constrained closed-loop system with certain active sets, independent of the choice of tuning parameters. To cope with these problems and extend the constraint handling capabilities of MPC, we introduce the consideration of soft constraints. We compare the use of the l2-(quadratic), l1-(exact), and l∞-norm penalty formulations. The analysis reveals a strong similarity between the control laws, which allows a direct extrapolation of the unconstrained tuning guidelines to the constrained case. In particular, the exact penalty treatment has identical stability characteristics to the correspondent unconstrained case and therefore seems well suited for general soft constraint handling, even with nonlinear models. These extensions are included in the previously developed Newton control framework, allowing the use of the approach within a consistent framework for both linear and nonlinear process models, increasing the scope of applications of the method. Process examples illustrate the capabilities of the proposed approaches.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 25 (1985), S. 1048-1054 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Blends of poly(2,6-dimethyl-1,4-phenylene oxide) (PMMPO) and poly(4-methylstyrene) (P4MS) were found to be compatible from a variety of experimental methods including calorimetric, density, and mechanical property measurements. Blend property behavior was similar to that widely reported for PMMPO/polystyrene (PS) blends. For each blend composition studied, a single glass transition temperature (Tg) was detected by differential scanning calorimetry. The compositional dependence of blend Tg was equally well represented by the empirical inverse rule of mixtures or by the Couchman thermodynamic expression. Density measurements of molded films suggested a mild excess volume of mixing that was slightly smaller than that observed for blends of PMMPO and PS. As in the case for PMMPO/PS, densification in the solid state may be associated with the observed mechanical property behavior of the PMMPO/P4MS blends. Initial modulus at each blend composition was larger than would be predicted by a simple weighted average of component polymer values. Tensile deformation changed from a ductile to a brittle mode of failure with increasing P4MS composition. The yield stress for ductile compositions and ultimate stress of brittle samples were both higher than found for the corresponding unblended polymers and higher than would be predicted from a simple additive relationship of weighted component properties. Blend impact strength determined by small strain rate tensile tests rapidly decreased to low levels with increasing P4MS composition. This drop in impact strength became more composition sensitive at higher loading rates during multiaxial deformation in an instrumented dart impact tester.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 1234-1234 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...