ISSN:
1573-8744
Keywords:
disopyramide
;
pharmacokinetics
;
bioavailability
;
metabolite
;
half-life
;
protein binding
;
disease states
;
drug-drug interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Current information on the pharmacokinetics of disopyramide is reviewed with emphasis on the implications for antiarrhythmic therapy. The absolute bioavailability, the disposition half-life, the plasma clearance, and the renal clearance for normal subjects and patients are discussed. Drug-drug interactions are discussed, and a new flexible intravenous dosing schedule is proposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059032
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