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  • Chemistry  (16)
  • induced protein  (1)
  • regulation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    On-line state and parameter Identification of positive photoresist development (1990)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 36 (1990), S. 1046-1053 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The development phase of the optical photolithography process has long been considered the most crucial, as it is the final image-forming step. Process monitoring methods have focused primarily on end point detection and have not used other inferable on-line information. This paper examines the use of mathematical models in conjunction with on-line development penetration data to determine process changes. An on-line sequential parameter identification scheme is used to calculate a current rate parameter value for the development model, and a Kalman filter is used to reduce erroneous observations caused by measurement noise. A powerful development monitor system results from the combination of real-time data, and on-line parameter and state estimation theory.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690360711
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Optimal fed-batch control of induced foreign protein production by recombinant bacteria (1994)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 40 (1994), S. 899-907 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Optimal control strategies for maximizing the production of induced foreign protein by recombinant bacteria were sought by the optimal control theory. Nutrient and inducer feeding rates were selected as key control variables. Since the problem is linear in the control variables, the optimal control is bang-bang or singular. Singular solutions are shown to exist. The optimal control theory showed that the specific growth rate with respect to nutrient concentration must be kept in its maximum phase and that there exist both a cell growth period and a protein production periods. The optimal control theory calculates exactly the growth and production periods. The glucose concentration is controlled along a singular are to give a maximum specific growth rate. The inducer level is controlled along a separate singular arc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690400516
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  • 3
    Electronic Resource
    Electronic Resource
    Optimal temperature control for batch beer fermentation (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 224-234 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Optimal control theory was applied to the process of batch beer fermentation. The performance functional considered was a weighted sum of maximum ethanol production and minimum time. Calculations were based on the model of Engasser et al. modified to include temperature effects. Model parameters were determined from isothermal batch fermentations. The fermentor cooling duty was the single available control. Temperature state variable constraints as well as control variable constraints were considered. The optimal control law is shown to be bang-bang control with the existence of a singular arc corresponding to isothermal operation at the maximum temperature constraint. An iterative algorithm is presented for computing appropriate switching times using a penalty-function-augmented performance functional.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310308
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dynamics of foreign protein secretion from Saccharomyces cerevisiae (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 33 (1989), S. 272-281 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model describing the dynamics of foreign protein secretion from yeast cells is developed. The secretion events, which are a series of complicated enzymatic reactions and carrier-involved transport, are lumped to a practically applicable model structure, based on the major interactions between the heterologous polypeptides and the host cell's secretory machinery through the pathway. The developed model structure predicts that the secretion rate constant is represented as a saturated form with respect to the host cell's specific growth rate. The validity of the proposed model structure is tested by generating dynamic response data to a step input of cycloheximide. The model system used in the experiment is SEY2102-s21, which has an integrated copy of a yeast secretion-mutant invertase that simulates well typical gene cassettes designed to secrete mature foreign proteins utilizing the yeast cell's secretion signals. Protein quantification is done by gel electrophoresis followed by immuno-blot on nitrocellulose filters and subsequent scanning with a reflectance densitometer. Experimental data confirm the proposed model structure.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260330305
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Analytical and knowledge-based redundancy for fault diagnosis in process plants (1993)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 39 (1993), S. 42-56 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The increasing complexity of process plants and their reliability have necessitated the development of more powerful methods for detecting and diagnosing process abnormalities. Among the underlying strategies, analytical redundancy and knowledge-based system techniques offer viable solutions. In this work we consider the adaptive inclusion of analytical redundancy models (state and parameter estimation modules) in the diagnostic reasoning loop of a knowledge-based system. This helps overcome the difficulties associated with each category. The design method is a new layered knowledge base that houses compiled/qualitative knowledge in the high levels and process-general estimation knowledge in the low levels of a hierarchical knowledge structure. The compiled knowledge is used to narrow the diagnostic search space and provide an effective way of employing estimation modules. The estimation-based methods that resort to fundamental analysis provide the rationale for a qualitatively-guided reasoning process. The overall structure of the fault detection and isolation system based on the combined strategy is discussed focusing on the model-based redundancy methods which create the low levels of the hierarchical knowledge base. The system has been implemented using the condensate-feedwater subsystem of a coal-fired power plant. Due to the highly nonlinear and mixed-mode nature of the power plant dynamics, the modified extended Kalman filter is used in designing local detection filters.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690390107
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  • 6
    Electronic Resource
    Electronic Resource
    Simultaneous optimal bottom linewidth and side-wall curvature control of wet etching (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 2576-2581 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Etching is one of the critical steps in the fabrication of microelectronics devices. A time-optimal control problem with a dual-term terminal cost including both bottom linewidth and side-wall curvature is formulated to implement an optimal open-width design principle. A singular-arc solution does not exist and the control action is bangbang. The optimal switching time is analytically calculated. The feasibility and effectiveness of this technique are illustrated by simulation studies. This design and control philosophy can easily be applied to other microelectronics manufacturing processes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690420918
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  • 7
    Electronic Resource
    Electronic Resource
    Balanced realization for state-space identification and optimal output regulation (1995)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 1217-1228 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new input - output approach is presented for optimal regulatory control of systems based on balanced state realization. State-space identification is achieved using input-output data and a balanced realization algorithm. Based on the realized model, an optimal controller design is presented to regXSulate the system outputs at desired levels. The optimal control algorithm is model-predictive in that predictions are made based on measured disturbances. It also compensates for unmeasured disturbances through integral state feedback. This control concept is tested using a continuous stirred-tank chemical reactor model.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690410517
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  • 8
    Electronic Resource
    Electronic Resource
    Mathematical modeling of induced foreign protein production by recombinant bacteria (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 39 (1992), S. 635-646 
    Details
    ISSN: 0006-3592
    Keywords: induced protein ; mathematical modeling ; recombinant bacteria ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new generalized mathematical model for recombinant bacteria which includes inducer effects on cell growth and foreign protein production is developed. The model equation set was applied to a host-vector system, Escherichi coli D1210 and plasmid pSD8. Batch experiments were designed and performed in shake flasks to verify the model. A parameter estimation method was developed and proven to be efficient. Although simple, the model can effectively describe the dynamics of the production of foreign protein in recombinant bacteria and can be used for optimization and control studies to maximize foreign protein production.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260390608
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  • 9
    Electronic Resource
    Electronic Resource
    The dynamic modeling, stability, and control of a continuous stirred tank chemical reactor (1969)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 15 (1969), S. 853-860 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A realistic CSTR model was developed and verified experimentally. The reaction studied was the exothermic, base sodium hydroxide catalyzed decomposition of hydrogen peroxide. The model was used to evaluate the usefulness of the following stability analyses: steady state analysis, local linearization and Liapunov's direct method through Krasovskii's theorem. The effect of control valve hysteresis on the system was also investigated.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690150611
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  • 10
    Electronic Resource
    Electronic Resource
    Convergence properties of systems of algebraic equations - explicit loops (1973)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 19 (1973), S. 566-574 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Techniques are developed for using the structural information contained in algebraic equation sets to aid in the study of convergence properties of iterative equation loops.The concept of inverse mapping is applied directly in order to study convergence properties of sequences. For problems in which there exist both a direct and inverse path for the computation of iterative loops, direct substitution techniques will converge via one path and diverge via the other path. When an inverse path existed, the direct substitution method was superior to simultaneous solution techniques for the problems studied. Not all iterative loops have an inverse path. For problems in which inverse paths do not originally exist, rearrangement of the equations of an iterative loop can result in a modified loop for which an inverse path does exist. The digraph representation of an iterative loop aids in deciding whether rearrangements are feasible for a particular problem. When inverse paths cannot conveniently be obtained, direct substitution cannot be successfully used and simultaneous solution techniques such as quasi-linearization are recommended.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690190323
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