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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of melt-polymerizable aminophthalocyanine monomers (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 57 (1995), S. 77-85 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The strategy, synthesis, and characterization of a soluble amine-functionalized phthalocyanine monomer and two examples of its polymerization into optically transparent glasses are reported. A simple, fast, and versatile method for incorporating metal ions into the metal-free phthalocyanine is demonstrated. Measurements of the nonlinear optical properties associated with a lead-substituted phthalocyanine/urethane copolymer are also reported. © 1995 John Wiley & Sons, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070570108
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  • 2
    Electronic Resource
    Electronic Resource
    Histidine decarboxylase from rat and rabbit brain: Partial purification and characterization (1990)
    Springer
    Neurochemical research 15 (1990), S. 17-24 
    Details
    ISSN: 1573-6903
    Keywords: Histidine decarboxylase ; histamine synthesis ; brain ; purification ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histidine decarboxylase, the synthetic enzyme for histamine, was partially purified from regions of rat or rabbit brain rich in the enzyme. The enzyme was purified using ion exchange and hydrophobic column chromatography and chromatofocusing. Approximately 70-fold and 110-fold enrichments were attained from rat and rabbit brain, respectively. Rat and rabbit brain histidine decarboxylase had isoelectric points of pH 5.4 and 5.6, Km values of 80 μM and 120 μM histidine and Vmax values of 210 and 625 pmol histamine formed/hr-mg protein, respectively. The partially purified histidine decarboxylase from both sources was dependent on pyridoxal phosphate for maximal activity and was inhibited by α-fluoromethylhistidine, nickel chloride and cobaltous chloride but was not inhibited by impromidine, α-methyldopa, DTNB, zinc chloride or mercuric chloride. The enzyme had a broad pH optimum between pH 7.2 and 8.0. These studies provide further information on the characteristics of mammalian histidine decarboxylase from brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00969179
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  • 3
    Electronic Resource
    Electronic Resource
    The interaction of Ca2+-binding proteins with the carbocyanine dye stains-allThis study was supported by NIH Grant AM 30322-04. (1986)
    New York : Wiley-Blackwell
    Biopolymers 25 (1986), S. 1579-1595 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The interaction of the carbocyanine dye Stains-all with the Ca2+-binding proteins calmodulin, troponin C, and parvalbumin has been monitored by means of absorption spectra and CD. In the absence of Ca2+, complexes with Stains-all of all three proteins exhibit at high dye: protein mole ratios an intense J absorption band at 600-650 nm, which is associated with a characteristic CD spectrum. In the cases of calmodulin and troponin C, the J-band is progressively lost as the dye: protein ratio decreases and is replaced by bands of the γ and β types at 450-550 nm, which likewise give rise to characteristic CD spectra. For parvalbumin, only the J-band is observed; its intensity is undiminished at the lowest dye: protein ratios examined. In the presence of excess Ca2+ the J-band is lost for all three proteins. For calmodulin and troponin C it is replaced by σ- and β-bands; in the case of parvalbumin the bound dye is released. A tentative model has been proposed to account for these observations.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360250814
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  • 4
    Electronic Resource
    Electronic Resource
    The interaction of cyclosporin and calmodulin (1990)
    New York : Wiley-Blackwell
    Biopolymers 29 (1990), S. 1005-1014 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The interaction of cyclosporin A and dansyl cyclosporin A with bovine and wheat germ calmodulin has been monitored by measurements of induced changes in dansyl and bound toluidinyl naphthalene sulfonate fluorescence. The interaction is Ca2+-dependent and 1 : 1 Measurements of the efficiency of radiationless energy transfer from bound dansyl cyclosporin A to an acceptor group located on Cys-27 of wheat germ calmodulin suggest that the primary binding site is not located on the N-terminal lobe (residues 1-65). However, studies with proteolytic fragments of calmodulin indicate that elements of the N-terminal half-molecule (residues 1-77) may be involved in the stabilization of the binding site. The binding of cyclosporin alters the physical properties of calmodulin and, in particular, reduces the localized rotational mobility of a fluorescent probe.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360290612
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  • 5
    Electronic Resource
    Electronic Resource
    Hydrodynamic modes of arbitrarily shaped flexible macromolecules: Influence on dynamic light scattering (1993)
    New York : Wiley-Blackwell
    Biopolymers 33 (1993), S. 409-436 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The diffusional motions of flexible macromolecules are analyzed with an increasingly realistic Rouse-Zimm model, i.e., by modeling the molecule as an arbitrary set of spheres connected by nearly harmonic springs. New features include (1) nearly arbitrary arrangements of spheres, (2) arbitrary arrangements of translational and torsional springs, (3) significant anharmonic corrections to the elastic potential surface, and (4) inclusion of torsional damping and various hydrodynamic cross-coupling effects (including two types of translational-rotational coupling) with no additional fitted parameters.The hydrodynamic interactions [R. F. Goldstein (1985) Journal of Chemical Physics, Vol. 83, pp. 2390-2397] contain no adjustable parameters other than temperature, viscosity, and the radii and positions of the spheres. These hydrodynamic interactions allow accurate calculations of rigid body diffusion as well as flexible motions.Given the positions, radii, and spring constant matrix, one can calculate a full set of three-dimensional diffusional modes. Because one uses an off-diagonal hydrodynamic resistance matrix instead of a diagonal mass matrix, the diffusional modes are different in structure from vacuum normal modes, and give rise to different rms motions in the laboratory frame. These hydrodynamic modes include the effects of vibrational-translational cross-coupling (i.e., motion along a vibrational coordinate may give rise to a translational force, and vice versa).The diffusional modes are used to simulate dynamic light scattering (DLS). I examine various molecules with different shapes, flexibilities, and with different scattering vectors. Radial and angular motions influence DLS decays differently. These effects are dependent upon the molecular shape (straight, bent, or curved) and type of flexibility (stretching or bending). Furthermore, small cubic corrections to the potential surface can be significant for DLS of certain geometries such as straight rods and semicircles. © 1993 John Wiley & Sons, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360330309
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  • 6
    Electronic Resource
    Electronic Resource
    The use of nanosecond fluorometry in detecting conformational transitions of an allosteric enzyme (1975)
    New York : Wiley-Blackwell
    Biopolymers 14 (1975), S. 1933-1949 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Analysis of the time decay of fluorescence of 1-anilino-naphthalene-8-sulfonate bound to phosphorylase b reveals the presence of two components with different decay times. In glycylglycine buffer, pH 7.0, the addition of the activators AMP or IMP, or the conversion to phosphorylase a results in a preferential decrease in the amplitude of the component of longer decay time, arising probably from a preferential dissociation of 1-anilino-naphthalene-8-sulfonate from the corresponding site as a consequence of a change in molecular state.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1975.360140912
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  • 7
    Electronic Resource
    Electronic Resource
    An analysis of the sequence dependence of the structure and energy of A- and B-DNA models using molecular mechannics (1983)
    New York : Wiley-Blackwell
    Biopolymers 22 (1983), S. 969-1002 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Molecular-mechanics calculations have been carried out on the base-paired hexanucleoside pentaphosphates d(TATATA)2, d(ATATAT)2, d(A6)·d(T6), d(CGCGCG)2, d(GCGCGC)2, and d(C6)·d(G6) in both A- and B-DNA geometries. The calculated relative energies of these polymers are consistent with the relative stabilities of the polymers found experimentally. In particular, the results of our calculations support the observation that the homopolymer d(A)n·d(T)n is more stable in a B-DNA conformation, while the homopolymer d(G)n·d(C)n is more stable in an A-DNA conformation. The molecular interactions responsible for these differential stabilities include both inter- and intrastrand base stacking, as well as base-phosphate interactions. While definitive experiments on the heteropolymer stabilities have not yet been carried out, the results of our calculations also suggest a greater stability of the purine-3′,5′-pyrimidine sequence over the pyrimidine-3′,5′-purine sequence in both the A- and B-conformations. The reason for this greater stability lies in the importance of the inherent directionality (5′ → 3′ vs 3′ → 5′) of phosphate-base and base-base interactions. The largest conformation change observed on energy refinement is sugar repuckering, which occurs mainly on pyrimidine-attched sugars and only in the B-DNA geometry. We suggest a molecular mechanism, specifically, differential base-sugar steric interactions involving neighboring sugars, to explain why this repuckering occurs more with d(A6)·d(T6) than with other isomers.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360220316
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  • 8
    Electronic Resource
    Electronic Resource
    The interaction of auramine O with calmodulin: Location of the binding site on the connecting strand (1992)
    New York : Wiley-Blackwell
    Biopolymers 32 (1992), S. 73-83 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The cationic dye auramine O forms a fluorescent complex with Ca2+-liganded calmodulin. One moderately strong binding site is present, as well as one or more weaker sites. The binding site for auramine O is different from those for toluidinyl-naphthalene sulfonate. The dependence of binding upon electrolyte concentration suggests a substantial electrostatic component of the free energy of binding. The splitting of the bond between residues 77 and 78 by trypsin digestion abolishes auramine O binding; the N- and C-terminal half-molecules have virtually no binding capacity. This suggests that the primary binding site is located near the midpoint of the connecting strand and includes elements of both half-molecules. Thrombin digestion, which splits calmodulin between residues 106 and 107, also substantially reduces auramine O binding; this may be interpreted in terms of the stabilization of the structure of the connecting strand by interaction with residues within binding domain IV. The binding affinity at pH 5.0, where the helical organization of the connecting strand may be intact, is greater than at neutral pH.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360320110
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  • 9
    Electronic Resource
    Electronic Resource
    How many numbers are required to specify sequence-dependent properties of polynucleotides? (1992)
    New York : Wiley-Blackwell
    Biopolymers 32 (1992), S. 1679-1693 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: There are 10 unique dinucleotides of double-stranded DNA, but only 8 independent nearest-neighbor energies that occur in circular DNA, as shown by D. M. Gray and I. Tinoco [(1970) Biopolymers 9, 223-244]. We extend that analysis to include end effects, and show that the number of unique dinuoleotide pairs (including ends) is 14. but there are only 12 independent energies. We discuss how these 12 energies (or spectra or any other pairwise additive property) can be measured and displayed, and how they should and should not be compared between experimenters. As an example, we analyzed the recently reported melting curves [M. J. Doktycz et al. (1992) Biopolymers, 32, 849-864] of 16 DNA dumbbells in two different Na+ environments. This analysis reveals a new means for evaluating end effects and the emergence of longer than nearest-neighbor interactions at low salt concentration. © 1992 John Wiley & Sons, Inc.
    Additional Material: 13 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360321210
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  • 10
    Electronic Resource
    Electronic Resource
    The reaction between oximes and tervalent phosphorus compounds: A low-temperature radical rearrangement process (1982)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 115 (1982), S. 2560-2573 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Reaktion zwischen Oximen und dreiwertigen Phosphorverbindungen: Radikalische Umlagerung bei niedriger TemperaturKetoxime reagieren mit X2PCl-Verbindungen X = Ph, Me2N, EtO, X2 = OCH2CH2O) bei niedrigen Temperaturen (-60 bis -80°C) in Gegenwart von Triethylamin zu einem PIII-Zwischenprodukt 2, das unimolekular zum entsprechenden N-Phosphinylimin 3 umlagert. Freie Radikale, die durch Abfangen des im Anfangsschritt gebildeten Phosphonyl-Radikals entstanden sind, werden durch ESR-Spektroskopie nachgewiesen, und Hinweise auf einen Radikalkäfig-Prozeß werden von 31P-CIDNP-Untersuchungen erhalten. Bei X2 = OCH2CH2O kann die PIII-Zwischenstufe (2d, e) isoliert werden, deren Konstitutionen anhand der 13C-NMR-Spektren zugeordnet werden. Nach kinetischen Messungen lagert 2e bei 30-60°C ca. 10mal langsamer um als die offenkettige Verbindung 2 mit X = OEt. Die negative Aktivierungs-Entropie zeigt, daß 2e teilweise über einen cyclischen Übergangszustand umlagert.
    Notes: Ketoximes react rapidly with X2PCl compounds were X = Ph, Me2N, EtO and X2 = OCH2CH2O at low temperatures (-60 to -80°C) in the presence of triethylamine to give a PIII intermediate 2, which rearranges by a unimolecular process to the corresponding N-phosphinylated imine 3. Free radicals, formed by capture of the initially produced phosphonyl radical, are detected by ESR spectroscopy, and evidence for a radical cage process is obtained from 31P CIDNP studies. Where X2 = OCH2CH2O, the PIII intermediate (2d, e) can be isolated, and the structure established from the 13C NMR spectra. Kinetic measurements show compound 2e to rearrange (30-60°C) ca. 10 times more slowly than the open chain compound (X = OEt), and the negative activation entropy suggests that this particular system (2e) rearranges, in part, by a cyclic transition state.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19821150719
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