ISSN:
1042-7163
Keywords:
Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The deoxyribonucleoside 3′-bis(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite units (3) are used in the chemical synthesis of oligodeoxyribonucleotides on solid supports. The new phosphite units (3) were prepared easily by reaction of nucleosides and tris-(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite (2). They are readily activated by N-methylimidazole under very mild conditions on a solid support. This operation involves a one step reaction, which is an advantage over both the phosphite and H-phosphonate approaches. The use of deoxyribonucleoside phosphite intermediates in the synthesis of antisense oligodeoxyribonucleotides is also described.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hc.520020122
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